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Protein

Ras-related protein Rab-6.2

Gene

rab-6.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

  • adult locomotory behavior Source: UniProtKB
  • cellular protein localization Source: UniProtKB
  • early endosome to Golgi transport Source: UniProtKB
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • mechanosensory behavior Source: UniProtKB
  • protein localization to postsynaptic membrane Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-CEL-6811438. Intra-Golgi traffic.
R-CEL-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6.2
Gene namesi
Name:rab-6.2
ORF Names:T25G12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT25G12.4; CE07541; WBGene00004270; rab-6.2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • Golgi cisterna Source: WormBase
  • Golgi trans cisterna Source: WormBase
  • intracellular Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Ras-related protein Rab-6.2PRO_0000121119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity
Modified residuei205 – 2051Cysteine methyl esterBy similarity
Lipidationi205 – 2051S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ22782.
PaxDbiQ22782.
PRIDEiQ22782.

Expressioni

Gene expression databases

BgeeiWBGene00004270.
ExpressionAtlasiQ22782. baseline.

Interactioni

Protein-protein interaction databases

BioGridi46636. 1 interaction.
IntActiQ22782. 3 interactions.
STRINGi6239.T25G12.4.

Structurei

3D structure databases

ProteinModelPortaliQ22782.
SMRiQ22782. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiQ22782.
KOiK07893.
OMAiELNIMFM.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ22782.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFGNPLKK FKLVFLGEQS VGKTSLITRF MYDSFDNTYQ ATIGIDFLSK
60 70 80 90 100
TMYLEDRTVR LQLWDTAGQE RFRSLIPSYI RDSTVAVVVY DITNSNSFHQ
110 120 130 140 150
TSKWIDDVRT ERGSDVIIML VGNKTDLSDK RQVTTDEGER KAKELNVMFI
160 170 180 190 200
ETSAKAGYNV KQLFRRIAGA LPGIIKDDPV EPPNVVTMDP IRQRQIVTDE

GSCWC
Length:205
Mass (Da):23,365
Last modified:November 1, 1996 - v1
Checksum:iCFD639343EB5B552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081722 Genomic DNA. Translation: CCD74453.1.
PIRiT34375.
RefSeqiNP_510790.1. NM_078389.3.
UniGeneiCel.38941.

Genome annotation databases

EnsemblMetazoaiT25G12.4; T25G12.4; WBGene00004270.
GeneIDi181759.
KEGGicel:CELE_T25G12.4.
UCSCiT25G12.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081722 Genomic DNA. Translation: CCD74453.1.
PIRiT34375.
RefSeqiNP_510790.1. NM_078389.3.
UniGeneiCel.38941.

3D structure databases

ProteinModelPortaliQ22782.
SMRiQ22782. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46636. 1 interaction.
IntActiQ22782. 3 interactions.
STRINGi6239.T25G12.4.

Proteomic databases

EPDiQ22782.
PaxDbiQ22782.
PRIDEiQ22782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT25G12.4; T25G12.4; WBGene00004270.
GeneIDi181759.
KEGGicel:CELE_T25G12.4.
UCSCiT25G12.4. c. elegans.

Organism-specific databases

CTDi181759.
WormBaseiT25G12.4; CE07541; WBGene00004270; rab-6.2.

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiQ22782.
KOiK07893.
OMAiELNIMFM.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ22782.

Enzyme and pathway databases

ReactomeiR-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-CEL-6811438. Intra-Golgi traffic.
R-CEL-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ22782.

Gene expression databases

BgeeiWBGene00004270.
ExpressionAtlasiQ22782. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB6B_CAEEL
AccessioniPrimary (citable) accession number: Q22782
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.