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Protein

Ras-related protein Rab-6.2

Gene

rab-6.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB

GO - Biological processi

  • adult locomotory behavior Source: UniProtKB
  • cellular protein localization Source: UniProtKB
  • early endosome to Golgi transport Source: UniProtKB
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • mechanosensory behavior Source: UniProtKB
  • protein localization to postsynaptic membrane Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of AMPA receptor activity Source: UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.
R-CEL-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-CEL-6811438. Intra-Golgi traffic.
R-CEL-6811440. Retrograde transport at the Trans-Golgi-Network.
R-CEL-8854214. TBC/RABGAPs.
R-CEL-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6.2
Gene namesi
Name:rab-6.2
ORF Names:T25G12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT25G12.4; CE07541; WBGene00004270; rab-6.2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GOC
  • Golgi cisterna Source: WormBase
  • Golgi trans cisterna Source: WormBase
  • intracellular Source: UniProtKB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211191 – 205Ras-related protein Rab-6.2Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi203S-geranylgeranyl cysteineBy similarity1
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ22782.
PaxDbiQ22782.
PRIDEiQ22782.

Expressioni

Gene expression databases

BgeeiWBGene00004270.
ExpressionAtlasiQ22782. baseline.

Interactioni

Protein-protein interaction databases

BioGridi46636. 1 interactor.
IntActiQ22782. 3 interactors.
STRINGi6239.T25G12.4.

Structurei

3D structure databases

ProteinModelPortaliQ22782.
SMRiQ22782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
GeneTreeiENSGT00730000110423.
HOGENOMiHOG000233968.
InParanoidiQ22782.
KOiK07893.
OMAiMYQATIG.
OrthoDBiEOG091G0ORZ.
PhylomeDBiQ22782.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22782-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFGNPLKK FKLVFLGEQS VGKTSLITRF MYDSFDNTYQ ATIGIDFLSK
60 70 80 90 100
TMYLEDRTVR LQLWDTAGQE RFRSLIPSYI RDSTVAVVVY DITNSNSFHQ
110 120 130 140 150
TSKWIDDVRT ERGSDVIIML VGNKTDLSDK RQVTTDEGER KAKELNVMFI
160 170 180 190 200
ETSAKAGYNV KQLFRRIAGA LPGIIKDDPV EPPNVVTMDP IRQRQIVTDE

GSCWC
Length:205
Mass (Da):23,365
Last modified:November 1, 1996 - v1
Checksum:iCFD639343EB5B552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081722 Genomic DNA. Translation: CCD74453.1.
PIRiT34375.
RefSeqiNP_510790.1. NM_078389.3.
UniGeneiCel.38941.

Genome annotation databases

EnsemblMetazoaiT25G12.4; T25G12.4; WBGene00004270.
GeneIDi181759.
KEGGicel:CELE_T25G12.4.
UCSCiT25G12.4. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRAB6B_CAEEL
AccessioniPrimary (citable) accession number: Q22782
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families