Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

NEPrilysin metallopeptidase family

Gene

nep-22

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM13.016.

Names & Taxonomyi

Protein namesi
Submitted name:
NEPrilysin metallopeptidase familyImported
Gene namesi
Name:nep-22Imported
ORF Names:CELE_T25B6.2Imported, T25B6.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT25B6.2; CE14174; WBGene00020788; nep-22.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 3024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ22763.
PaxDbiQ22763.
PRIDEiQ22763.

Interactioni

Protein-protein interaction databases

STRINGi6239.T25B6.2.

Structurei

3D structure databases

ProteinModelPortaliQ22763.
SMRiQ22763. Positions 70-795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 502418Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini573 – 792220Peptidase_M13InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000015930.
InParanoidiQ22763.
OMAiCANGATT.
OrthoDBiEOG71VSXF.
PhylomeDBiQ22763.

Family and domain databases

Gene3Di3.40.390.10. 3 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 2 hits.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

Q22763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAIPLVTI AAVVIAVGIA IGSLVLNIII LGNVNTLTTT VNNNPVYHYT
60 70 80 90 100
PAPQVNSTPG TVNTSPSYTQ AANYLLNGLD DTVDPCQDFY AFTCNKFLQN
110 120 130 140 150
TDLQKLGRSR LGTYDQAQVD VYSEIVAALS KIDVTSTTTS KTERITKAAF
160 170 180 190 200
ETCKNNLASP ADKTAVVYAE ITSLFGGVPF FGEPLKTNVD YWMVAGQIEQ
210 220 230 240 250
KHAVGTLTYT IASSDYKDHT KNALYTGPPG LSLARDFYVK PQYIAEVNQR
260 270 280 290 300
VSDVNDLLTA FANAAKKNVG ADALLAAAQE VVNFEVQIAM ASWPDDLLRN
310 320 330 340 350
YQQQYNPYNI ASATTAYRAI NWKSYLGQLF HGVASDADQA NYNIVVTEPS
360 370 380 390 400
YFAWLNSVFD GKTSNSTVVA NYMIAQLLAD ESDFINPATA KVSSDTNYIH
410 420 430 440 450
YALRNGRGIK KIGKREYRMA DLDGISEGCM DLLTAYMPYG TGYVYVKSKS
460 470 480 490 500
ERNKVQADVK DQTTLIINNF QGMIDSLNWM DTFSKNRAHN KSDSLVKNFG
510 520 530 540 550
WPEAMFGDFN DFTTVDAYNQ DYASIIDLYT KDKNDIYGIF AVLKKGMEVR
560 570 580 590 600
EFFRIMGEPA DRTNFLQSPA MVNAWYQPER NSITFPYAAW NPPYYNLNYP
610 620 630 640 650
QAYNFAGQGG TGGHELTHGY DDEGVQFGFN GELTDCSWNK CGWMDTNSSS
660 670 680 690 700
GFIDMAQCVV TQFSTQCCPE KTGNIHCANG ATTQGENIAD LGGQQAAYRS
710 720 730 740 750
YRQYVATTRK GVEEDRLPGL ENYTPNQIFW ITYGYSWCMK QSDANLVHQL
760 770 780 790
LTNPHSPAQC RTNQVMQDIP EFGKDFGCVR GSPMYPEPSG RCKVWVGQ
Length:798
Mass (Da):88,549
Last modified:June 1, 1998 - v2
Checksum:iD4A4930B7855FE9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD65388.1.
PIRiT28906.
RefSeqiNP_509528.1. NM_077127.4.
UniGeneiCel.5134.

Genome annotation databases

EnsemblMetazoaiT25B6.2; T25B6.2; WBGene00020788.
GeneIDi181144.
KEGGicel:CELE_T25B6.2.
UCSCiT25B6.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD65388.1.
PIRiT28906.
RefSeqiNP_509528.1. NM_077127.4.
UniGeneiCel.5134.

3D structure databases

ProteinModelPortaliQ22763.
SMRiQ22763. Positions 70-795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T25B6.2.

Protein family/group databases

MEROPSiM13.016.

Proteomic databases

EPDiQ22763.
PaxDbiQ22763.
PRIDEiQ22763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT25B6.2; T25B6.2; WBGene00020788.
GeneIDi181144.
KEGGicel:CELE_T25B6.2.
UCSCiT25B6.2. c. elegans.

Organism-specific databases

CTDi181144.
WormBaseiT25B6.2; CE14174; WBGene00020788; nep-22.

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
GeneTreeiENSGT00760000119162.
HOGENOMiHOG000015930.
InParanoidiQ22763.
OMAiCANGATT.
OrthoDBiEOG71VSXF.
PhylomeDBiQ22763.

Family and domain databases

Gene3Di3.40.390.10. 3 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 2 hits.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22763_CAEEL
AccessioniPrimary (citable) accession number: Q22763
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: June 1, 1998
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.