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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-40

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.9.6.4. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-40Imported
ORF Names:CELE_T24D8.1Imported, T24D8.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT24D8.1; CE31248; WBGene00020767; lgc-40.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei250 – 26819HelicalSequence analysisAdd
BLAST
Transmembranei275 – 29622HelicalSequence analysisAdd
BLAST
Transmembranei308 – 32922HelicalSequence analysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 494472Sequence analysisPRO_5004200674Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ22741.
PRIDEiQ22741.

Interactioni

Protein-protein interaction databases

IntActiQ22741. 1 interaction.
MINTiMINT-214095.
STRINGi6239.T24D8.1.

Structurei

3D structure databases

ProteinModelPortaliQ22741.
SMRiQ22741. Positions 34-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 233201Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini249 – 487239Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231336.
InParanoidiQ22741.
KOiK05397.
OMAiVISWFNF.
OrthoDBiEOG712TVZ.
PhylomeDBiQ22741.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLHTMIRFL LSVCCIVNVF ESADLAFIPL TKAFLDKLKN ETLYNRFATP
60 70 80 90 100
TQYDGVPTNV TLSMFIEGMS SFSAQTMDYH LDVYFQEEWY DHRLAHNASA
110 120 130 140 150
PILVRDLTVF KMMWHPDVYF ANARSAAFQD ITDDNFLVWV YPNGRVWYDA
160 170 180 190 200
RISIVSSCNM DLWKYPLDSQ ECALRILSYA YPMTVLRLLW SEKEDVPAID
210 220 230 240 250
RNPDITMPDM SLKHIRTGYC NGTYATGEWS CMTAIFYVER EMMHHVMQTY
260 270 280 290 300
VPTALIVVIS WFNFWLEIDS APARVSLSIT TLLTISTQAN AVKLALPEVS
310 320 330 340 350
YMKAIDVWMG SCMAFVFGVM IEFTICHYAK NLEMLRGDGQ PSLIVDTALS
360 370 380 390 400
TLFGAARDID DLVRKVATLN EEEGVRGDGE QHIALNMLNP EEPRLRSLNQ
410 420 430 440 450
NNDVTANGTR YFVGAERMKR KRSKASLSRL RQQVASMRHA TIDVSRRAFN
460 470 480 490
WTRALRNLRG RRVAQRIDER CRIVFPMIFL LFNVAYWSFY LVFN
Length:494
Mass (Da):57,005
Last modified:October 1, 2002 - v2
Checksum:iAF6C18A5F7D04E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD71459.1.
PIRiT16935.
RefSeqiNP_508428.2. NM_076027.5.
UniGeneiCel.19805.

Genome annotation databases

EnsemblMetazoaiT24D8.1; T24D8.1; WBGene00020767.
GeneIDi188854.
KEGGicel:CELE_T24D8.1.
UCSCiT24D8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD71459.1.
PIRiT16935.
RefSeqiNP_508428.2. NM_076027.5.
UniGeneiCel.19805.

3D structure databases

ProteinModelPortaliQ22741.
SMRiQ22741. Positions 34-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22741. 1 interaction.
MINTiMINT-214095.
STRINGi6239.T24D8.1.

Protein family/group databases

TCDBi1.A.9.6.4. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Proteomic databases

PaxDbiQ22741.
PRIDEiQ22741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT24D8.1; T24D8.1; WBGene00020767.
GeneIDi188854.
KEGGicel:CELE_T24D8.1.
UCSCiT24D8.1. c. elegans.

Organism-specific databases

CTDi188854.
WormBaseiT24D8.1; CE31248; WBGene00020767; lgc-40.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000231336.
InParanoidiQ22741.
KOiK05397.
OMAiVISWFNF.
OrthoDBiEOG712TVZ.
PhylomeDBiQ22741.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22741_CAEEL
AccessioniPrimary (citable) accession number: Q22741
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.