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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-40

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.9.6.4 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-40Imported
ORF Names:CELE_T24D8.1Imported, T24D8.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT24D8.1 ; CE31248 ; WBGene00020767 ; lgc-40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei250 – 268HelicalSequence analysisAdd BLAST19
Transmembranei275 – 296HelicalSequence analysisAdd BLAST22
Transmembranei308 – 329HelicalSequence analysisAdd BLAST22
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500420067423 – 494Sequence analysisAdd BLAST472

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ22741

Expressioni

Gene expression databases

BgeeiWBGene00020767

Interactioni

Protein-protein interaction databases

IntActiQ22741, 1 interactor
STRINGi6239.T24D8.1

Structurei

3D structure databases

ProteinModelPortaliQ22741
SMRiQ22741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 238Neur_chan_LBDInterPro annotationAdd BLAST206
Domaini249 – 487Neur_chan_membInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644 Eukaryota
ENOG410XP43 LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231336
InParanoidiQ22741
KOiK05273
OMAiVISWFNF
OrthoDBiEOG091G0805
PhylomeDBiQ22741

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q22741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLHTMIRFL LSVCCIVNVF ESADLAFIPL TKAFLDKLKN ETLYNRFATP
60 70 80 90 100
TQYDGVPTNV TLSMFIEGMS SFSAQTMDYH LDVYFQEEWY DHRLAHNASA
110 120 130 140 150
PILVRDLTVF KMMWHPDVYF ANARSAAFQD ITDDNFLVWV YPNGRVWYDA
160 170 180 190 200
RISIVSSCNM DLWKYPLDSQ ECALRILSYA YPMTVLRLLW SEKEDVPAID
210 220 230 240 250
RNPDITMPDM SLKHIRTGYC NGTYATGEWS CMTAIFYVER EMMHHVMQTY
260 270 280 290 300
VPTALIVVIS WFNFWLEIDS APARVSLSIT TLLTISTQAN AVKLALPEVS
310 320 330 340 350
YMKAIDVWMG SCMAFVFGVM IEFTICHYAK NLEMLRGDGQ PSLIVDTALS
360 370 380 390 400
TLFGAARDID DLVRKVATLN EEEGVRGDGE QHIALNMLNP EEPRLRSLNQ
410 420 430 440 450
NNDVTANGTR YFVGAERMKR KRSKASLSRL RQQVASMRHA TIDVSRRAFN
460 470 480 490
WTRALRNLRG RRVAQRIDER CRIVFPMIFL LFNVAYWSFY LVFN
Length:494
Mass (Da):57,005
Last modified:October 1, 2002 - v2
Checksum:iAF6C18A5F7D04E1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD71459.1
PIRiT16935
RefSeqiNP_508428.2, NM_076027.5
UniGeneiCel.19805

Genome annotation databases

EnsemblMetazoaiT24D8.1; T24D8.1; WBGene00020767
GeneIDi188854
KEGGicel:CELE_T24D8.1
UCSCiT24D8.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ22741_CAEEL
AccessioniPrimary (citable) accession number: Q22741
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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