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Protein

Mitochondrial import inner membrane translocase subunit TIM50

Gene

scpl-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM50
Alternative name(s):
Small C-terminal domain Phosphatase protein 4
Gene namesi
Name:scpl-4
Synonyms:tim-50
ORF Names:T21C9.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT21C9.12; CE06481; WBGene00011897; scpl-4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 167144Mitochondrial matrixSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Topological domaini189 – 452264Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionSequence analysisAdd
BLAST
Chaini24 – 452429Mitochondrial import inner membrane translocase subunit TIM50PRO_0000043120Add
BLAST

Proteomic databases

EPDiQ22647.
PaxDbiQ22647.
PRIDEiQ22647.

Interactioni

Subunit structurei

Component of the TIM23 complex at least composed of tim-23, tim-17 and tim-50.By similarity

Protein-protein interaction databases

STRINGi6239.T21C9.12.

Structurei

3D structure databases

ProteinModelPortaliQ22647.
SMRiQ22647. Positions 249-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini243 – 387145FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TIM50 family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2832. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00550000075036.
HOGENOMiHOG000154590.
InParanoidiQ22647.
KOiK17496.
OMAiMERNTRI.
OrthoDBiEOG773XH7.
PhylomeDBiQ22647.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR027111. Tim50.
[Graphical view]
PANTHERiPTHR12210:SF3. PTHR12210:SF3. 1 hit.
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSKLTQTC FSRHQAKTFI RLYSSDFKSL LGPPAVANPY ADNGRTRFAP
60 70 80 90 100
IVPINHGNVF ASIKLPINET QEAIAFKSEV EEAPKVEKLE VESPKIEAEK
110 120 130 140 150
VLSSPPPAPA PTSSAIDELN SLKDSLEKLE SAASKSSSSS GGSSDNSDPG
160 170 180 190 200
NAEEIEARRK RMERNTRIGA YVLFGGSIIG FISFCFYYGR AQRDEFGNVI
210 220 230 240 250
SDEFSGSFLA PFYRIANSFK LWRDYVVEPA REQLLPDPLP APYLQPKYTI
260 270 280 290 300
VIELKNILVH PEWTYKTGYR FLKRPALDYF LDVIGYPNFE VVIYSSESMM
310 320 330 340 350
TAAPVVDSFD PKQRIMYKLF RDCTKYMNGH HVKDLSKLNR DLSKVIYIDF
360 370 380 390 400
DAKSGQLNPE NMLRVPEWKG NMDDTSLVDL AELLKTIHLS DAEDVRPMLQ
410 420 430 440 450
YYSQYDDPAK EFRRRAVYLS QQEEQKKQQP DDSSMLKRYS GRLFGSRRHV

NA
Length:452
Mass (Da):51,378
Last modified:November 1, 1996 - v1
Checksum:i291C1F6A4E99A95A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73098 Genomic DNA. Translation: CAA97339.1.
PIRiT25076.
RefSeqiNP_505722.1. NM_073321.5.
UniGeneiCel.7629.

Genome annotation databases

EnsemblMetazoaiT21C9.12; T21C9.12; WBGene00011897.
GeneIDi179481.
KEGGicel:CELE_T21C9.12.
UCSCiT21C9.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73098 Genomic DNA. Translation: CAA97339.1.
PIRiT25076.
RefSeqiNP_505722.1. NM_073321.5.
UniGeneiCel.7629.

3D structure databases

ProteinModelPortaliQ22647.
SMRiQ22647. Positions 249-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T21C9.12.

Proteomic databases

EPDiQ22647.
PaxDbiQ22647.
PRIDEiQ22647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT21C9.12; T21C9.12; WBGene00011897.
GeneIDi179481.
KEGGicel:CELE_T21C9.12.
UCSCiT21C9.12. c. elegans.

Organism-specific databases

CTDi179481.
WormBaseiT21C9.12; CE06481; WBGene00011897; scpl-4.

Phylogenomic databases

eggNOGiKOG2832. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00550000075036.
HOGENOMiHOG000154590.
InParanoidiQ22647.
KOiK17496.
OMAiMERNTRI.
OrthoDBiEOG773XH7.
PhylomeDBiQ22647.

Miscellaneous databases

PROiQ22647.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
IPR027111. Tim50.
[Graphical view]
PANTHERiPTHR12210:SF3. PTHR12210:SF3. 1 hit.
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTIM50_CAEEL
AccessioniPrimary (citable) accession number: Q22647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.