ID   HPPD_CAEEL              Reviewed;         393 AA.
AC   Q22633;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 61.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            EC=1.13.11.27;
DE   AltName: Full=4-hydroxyphenylpyruvic acid oxidase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
GN   Name=hpd-1; ORFNames=T21C12.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; Z50016; CAA90315.1; -; Genomic_DNA.
DR   PIR; T25063; T25063.
DR   RefSeq; NP_499324.1; -.
DR   UniGene; Cel.10002; -.
DR   HSSP; P80064; 1CJX.
DR   SMR; Q22633; 7-367.
DR   Ensembl; T21C12.2; Caenorhabditis elegans.
DR   GeneID; 176473; -.
DR   KEGG; cel:T21C12.2; -.
DR   WormBase; WBGene00001993; hpd-1.
DR   WormPep; T21C12.2; CE02347.
DR   OMA; Q22633; VQDRPTV.
DR   BRENDA; 1.13.11.27; 672.
DR   NextBio; 892738; -.
DR   ArrayExpress; Q22633; -.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 2.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    393       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088395.
FT   METAL       182    182       Iron (By similarity).
FT   METAL       267    267       Iron (By similarity).
FT   METAL       350    350       Iron (By similarity).
SQ   SEQUENCE   393 AA;  44383 MW;  B2D66424ED2CE998 CRC64;
     MTTFDKGAKP DIGTFVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA
     IRQDKIVFIF ESALLPDNSE LGNHLVQHGD GVKDVCFEVE DLDSIIAHAK AAGATIVHDI
     TEESDADGSI RYATLRTYGE TDHTLLERKN YRGAFLPGFK AHPMPATFFK TLPRVGLNFL
     DHCVGNQPDL QMDSAVQWYE KVLKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN
     EPATSDKKAI SQIQEYVDYY GGSGVQHIAL NTSDIITAIE ALRARGCEFL SIPSSYYDNL
     KERLAASSMV VKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHEGF
     GAGNFKALFE SIELEQTKRG NLFYDNVKDG NTK
//