Q22633 (HPPD_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase
EC=1.13.11.27

Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name=4HPPD
Short name=HPD
Short name=HPPDase

Gene names

Name:	hpd-1
ORF Names:	T21C12.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Key enzyme in the degradation of tyrosine By similarity.
Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088395
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	267	1	Iron By similarity
	Metal binding	350	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q22633 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B2D66424ED2CE998	FASTA	393	44,383
	10 20 30 40 50 60 MTTFDKGAKP DIGTFVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA 70 80 90 100 110 120 IRQDKIVFIF ESALLPDNSE LGNHLVQHGD GVKDVCFEVE DLDSIIAHAK AAGATIVHDI 130 140 150 160 170 180 TEESDADGSI RYATLRTYGE TDHTLLERKN YRGAFLPGFK AHPMPATFFK TLPRVGLNFL 190 200 210 220 230 240 DHCVGNQPDL QMDSAVQWYE KVLKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN 250 260 270 280 290 300 EPATSDKKAI SQIQEYVDYY GGSGVQHIAL NTSDIITAIE ALRARGCEFL SIPSSYYDNL 310 320 330 340 350 360 KERLAASSMV VKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHEGF 370 380 390 GAGNFKALFE SIELEQTKRG NLFYDNVKDG NTK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50016 Genomic DNA. Translation: CAA90315.1.
PIR	T25063.
RefSeq	NP_499324.1. NM_066923.5.
UniGene	Cel.10002.
3D structure databases
ProteinModelPortal	Q22633.
SMR	Q22633. Positions 8-382.
ModBase	Search...
Protein-protein interaction databases
STRING	Q22633.
2D gel databases
World-2DPAGE	0020:Q22633.
Proteomic databases
PRIDE	Q22633.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T21C12.2; T21C12.2; T21C12.2.
GeneID	176473.
KEGG	cel:T21C12.2.
UCSC	T21C12.2. c. elegans.
Organism-specific databases
CTD	176473.
WormBase	T21C12.2; CE02347; WBGene00001993; hpd-1.
Phylogenomic databases
eggNOG	meNOG05269.
GeneTree	EMGT00050000016473.
HOGENOM	HBG680392.
InParanoid	Q22633.
OMA	HCVGNVE.
PhylomeDB	Q22633.
Gene expression databases
ArrayExpress	Q22633.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase. [Graphical view]
KO	K00457.
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...
Other
NextBio	892738.

Entry information

Entry name

HPPD_CAEEL

Accession

Primary (citable) accession number: Q22633

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project