Reviewed, UniProtKB/Swiss-Prot Q22633 (HPPD_CAEEL)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
    EC=1.13.11.27
Alternative name(s):
    4-hydroxyphenylpyruvic acid oxidase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD

Gene names

Name:	hpd-1
ORF Names:	T21C12.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088395
Sites
	Metal binding	182	1	Iron By similarity
	Metal binding	267	1	Iron By similarity
	Metal binding	350	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q22633-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B2D66424ED2CE998	FASTA	393	44,383
	10 20 30 40 50 60 MTTFDKGAKP DIGTFVAFDH VRFVVGNAKQ AAYWYCANFG FEPFAYKGLE TGSRITAQHA 70 80 90 100 110 120 IRQDKIVFIF ESALLPDNSE LGNHLVQHGD GVKDVCFEVE DLDSIIAHAK AAGATIVHDI 130 140 150 160 170 180 TEESDADGSI RYATLRTYGE TDHTLLERKN YRGAFLPGFK AHPMPATFFK TLPRVGLNFL 190 200 210 220 230 240 DHCVGNQPDL QMDSAVQWYE KVLKFHRFWS VDDSMIHTEY SALRSIVVTN FEETIKMPIN 250 260 270 280 290 300 EPATSDKKAI SQIQEYVDYY GGSGVQHIAL NTSDIITAIE ALRARGCEFL SIPSSYYDNL 310 320 330 340 350 360 KERLAASSMV VKEDMDRLQK LHILVDFDEN GYLLQIFSKP CQDRPTLFLE IIQRQNHEGF 370 380 390 GAGNFKALFE SIELEQTKRG NLFYDNVKDG NTK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z50016 Genomic DNA. Translation: CAA90315.1.
PIR	T25063.
RefSeq	NP_499324.1.
UniGene	Cel.10002
3D structure databases
HSSP	HSSP built from PDB template 1CJX based on UniProtKB P80064.
SMR	Q22633. Positions 7-367.
ModBase	Search...
Genome annotation databases
Ensembl	T21C12.2. Caenorhabditis elegans. [Contig view]
GeneID	176473.
KEGG	cel:T21C12.2.
Organism-specific databases
WormBase	WBGene00001993. hpd-1.
WormPep	T21C12.2. CE02347. [WorfDB]
Phylogenomic databases
OMA	Q22633. VQDRPTV.
Enzyme and pathway databases
BRENDA	1.13.11.27. 672.
Gene expression databases
ArrayExpress	Q22633.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	892738.

Entry information

Entry name

HPPD_CAEEL

Accession

Primary (citable) accession number: Q22633

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project