Reviewed, UniProtKB/Swiss-Prot Q22618 (ADR2_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable double-stranded RNA-specific adenosine deaminase
      Short name=DRADA
    EC=3.5.4.-

Gene names

Name:	adr-2
ORF Names:	T20H4.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Cofactor	Zinc By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 A to I editase domain. Contains 1 DRBM (double-stranded RNA-binding) domain.

Ontologies

Keywords
Biological process	mRNA processing
Cellular component	Nucleus
Ligand	Metal-binding RNA-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: InterPro double-stranded RNA binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
adbp-1	Q23129	1	EBI-328070,EBI-328078

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Probable double-stranded RNA-specific adenosine deaminase		PRO_0000171778
Regions
	Domain	36 – 105	70	DRBM
	Domain	167 – 492	326	A to I editase
Sites
	Active site	193	1	Proton donor By similarity
	Metal binding	191	1	Zinc By similarity
	Metal binding	244	1	Zinc By similarity
	Metal binding	305	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q22618-1 [UniParc]. Last modified November 1, 2002. Version 2. Checksum: EDE9D9E06A5A8A89	FASTA	495	55,320
	10 20 30 40 50 60 MSVEEGMEVE LKSEKMDLDD NIPDFVKETV ERSGKNPMSL FSELYVHMTG NTPVFDFYNR 70 80 90 100 110 120 NQPNGSMKFI CVVILNGERI EGNVKSKKKE AKVSCSLKGL EVVLKHVSEY VVPAVKFEEK 130 140 150 160 170 180 TTFFEMLREH TYAKFYELCK NNALIYGFEK VIASVFLKIN GNLQIIALST GNKGLRGDKI 190 200 210 220 230 240 VNDGTALIDC HAEILARRGL LRFLYSEVLK FSTEPPNSIF TKGKNALVLK PGISFHLFIN 250 260 270 280 290 300 TAPCGVARID KKLKPGTSDD LQNSSRLRFK IDKGMGTVLG GASEFEAPQT FDGIMMGERM 310 320 330 340 350 360 RTMSCSDKLL RANVLGVQGA ILSHFIDPIY YSSIAVAELN NADRLRKAVY SRAATFKPPA 370 380 390 400 410 420 PFHVQDVEIG ECQVEDTEQS TSAAARSTIS SMNWNLADGN TEVVRTSDGM VHDKDMSGAD 430 440 450 460 470 480 ITTPSRLCKK NMAELMITIC TLTKTSVDYP ISYEELKAGS QEYAAAKKSF ITWLRQKDLG 490 IWQRKPREFQ MFTIN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes." Hough R.F., Lingam A.T., Bass B.L. Nucleic Acids Res. 27:3424-3432(1999) [PubMed: 10446229] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF051275 mRNA. Translation: AAC25097.1. U00037 Genomic DNA. Translation: AAA50661.2.
PIR	T16913. T42758.
RefSeq	NP_498594.1.
UniGene	Cel.34304
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:26710N.
IntAct	Q22618. 2 interactions.
STRING	Q22618.
Genome annotation databases
Ensembl	T20H4.4.1; T20H4.4.1; T20H4.4; Caenorhabditis elegans. [Genome view] T20H4.4.2; T20H4.4.2; T20H4.4; Caenorhabditis elegans. [Genome view]
GeneID	176022.
KEGG	cel:T20H4.4.
UCSC	T20H4.4.1. c. elegans.
Organism-specific databases
CTD	176022.
WormBase	WBGene00000080. adr-2.
WormPep	T20H4.4. CE25120. [WorfDB]
Phylogenomic databases
OMA	FINTAPC
Gene expression databases
ArrayExpress	Q22618.
Family and domain databases
InterPro	IPR002466. A_deamin. IPR001159. Ds-RNA_bd. [Graphical view]
Pfam	PF02137. A_deamin. 1 hit. PF00035. dsrm. 1 hit. [Graphical view]
SMART	SM00552. ADEAMc. 1 hit. [Graphical view]
PROSITE	PS50141. A_DEAMIN_EDITASE. 1 hit. PS50137. DS_RBD. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	890784.

Entry information

Entry name

ADR2_CAEEL

Accession

Primary (citable) accession number: Q22618
Secondary accession number(s): O76295

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 2002
Last modified:	November 3, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project