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Q22601

- Q22601_CAEEL

UniProt

Q22601 - Q22601_CAEEL

Protein
Submitted name:

Protein APA-2

Gene

apa-2

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. GTPase activating protein binding Source: WormBase
    2. protein binding Source: IntAct
    3. protein C-terminus binding Source: WormBase
    4. protein transporter activity Source: InterPro

    GO - Biological processi

    1. embryo development ending in birth or egg hatching Source: WormBase
    2. intracellular protein transport Source: InterPro
    3. protein localization Source: WormBase
    4. receptor-mediated endocytosis Source: WormBase

    Keywords - Biological processi

    Protein transportSAAS annotation, Transport

    Enzyme and pathway databases

    SignaLinkiQ22601.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein APA-2Imported
    Gene namesi
    Name:apa-2Imported
    ORF Names:CELE_T20B5.1Imported, T20B5.1Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiT20B5.1; CE28680; WBGene00000161; apa-2.

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. clathrin-coated endocytic vesicle Source: WormBase
    3. endocytic vesicle Source: WormBase
    4. plasma membrane Source: WormBase

    Keywords - Cellular componenti

    MembraneSAAS annotation

    PTM / Processingi

    Proteomic databases

    PaxDbiQ22601.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    rme-4G5ECW93EBI-5323248,EBI-315316
    rme-6Q9GYH73EBI-5323248,EBI-320814

    Protein-protein interaction databases

    IntActiQ22601. 2 interactions.
    STRINGi6239.T20B5.1.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22601.
    SMRiQ22601. Positions 5-613, 682-925.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG303101.
    GeneTreeiENSGT00550000074757.
    HOGENOMiHOG000170596.
    InParanoidiQ22601.
    KOiK11824.
    OMAiWVIGGKD.
    OrthoDBiEOG7GQXV2.
    PhylomeDBiQ22601.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q22601-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAVKGDGMR GLAVFISDIR NCKSKEAELK RINKELANIR SKFKGDKTLD    50
    GYQKKKYVCK LLFIFLLGND IDFGHMEAVN LLSSNKYTEK QIGYLFISVL 100
    IEQQSDLMKL IVQGIRNDLT SRNPVHVNLA LQCISNMGSR EMVEAFCTDL 150
    PKLLVSGETI DFVKQSAALC ILKLFRNSPD SFQPGDYASR IVHLLNDSHM 200
    GVVTSAASLI EALSKKWPEE YKGAVPLAIS RLSRIVTATY TDLQDYTYYF 250
    VPAPWLCVKL LRLLQNYPPP DDPSNKARLL ECLEGILNKA QDAPKSKKVQ 300
    HSNAKNAVLF EAIALIIHMD SEPQLLVRAC NQLGTFLSHR ETNLRYLALE 350
    SMCLLATSEF SHDAVKKHQD TIINSLKTER DVSVRQRAVD LLYAMCDRSN 400
    ANQIVAEMLA YLETADYSIR EEMVLKVAIL AEKYATDYTW YVDVILKLIR 450
    IAGDYVSEEV WYRVIQIVVN REDVQGYAAK TVFEALQRPA CHENMVKVGG 500
    YILGEFGNFI AGDERSTAKI QFELLHSKFH LCSITTRCLL LTTYIKFCNL 550
    FPEIKPLVQQ VFQTDHNLRN PDAELQQRSI EYLQMTKLAS NDVLATILEV 600
    MPAFAEKESS LLAKLKKSKP QLEEIEREEK EKRSKPTAVM SEGSTSLVDF 650
    DSTNDTTASL ADVFANNSGT GLGAQGDEVE IANKDDYLKF VTKSNAILWE 700
    DDYIQIGCKL ETRNNLGRLG MFYGNKTSQP FNKFTPIITC PGALAVQLQA 750
    QAKPVEPVVA AGTQVQQLIN FVCVQEFQKM PIMNIKFTFT DRAGAVQNFD 800
    KNFYLPLFIS KFFEPTNMTS EQFFTRWKSL GAASQEAQKI FNALSPIEHA 850
    TIESRLKGFG ANLLTDVDPN PDNYVCAGII HTQTQQIGTL IRLEPNKQAK 900
    MYRLTIRSSK DTVVQTLVDL LGNQF 925
    Length:925
    Mass (Da):104,180
    Last modified:October 1, 2001 - v2
    Checksum:iA816ADC042FD557C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081025 Genomic DNA. Translation: CCD68583.1.
    PIRiT16911.
    RefSeqiNP_509572.1. NM_077171.6.
    UniGeneiCel.16972.

    Genome annotation databases

    EnsemblMetazoaiT20B5.1.1; T20B5.1.1; WBGene00000161.
    T20B5.1.2; T20B5.1.2; WBGene00000161.
    GeneIDi181163.
    KEGGicel:CELE_T20B5.1.
    UCSCiT20B5.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081025 Genomic DNA. Translation: CCD68583.1 .
    PIRi T16911.
    RefSeqi NP_509572.1. NM_077171.6.
    UniGenei Cel.16972.

    3D structure databases

    ProteinModelPortali Q22601.
    SMRi Q22601. Positions 5-613, 682-925.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q22601. 2 interactions.
    STRINGi 6239.T20B5.1.1.

    Proteomic databases

    PaxDbi Q22601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T20B5.1.1 ; T20B5.1.1 ; WBGene00000161 .
    T20B5.1.2 ; T20B5.1.2 ; WBGene00000161 .
    GeneIDi 181163.
    KEGGi cel:CELE_T20B5.1.
    UCSCi T20B5.1.1. c. elegans.

    Organism-specific databases

    CTDi 181163.
    WormBasei T20B5.1 ; CE28680 ; WBGene00000161 ; apa-2.

    Phylogenomic databases

    eggNOGi NOG303101.
    GeneTreei ENSGT00550000074757.
    HOGENOMi HOG000170596.
    InParanoidi Q22601.
    KOi K11824.
    OMAi WVIGGKD.
    OrthoDBi EOG7GQXV2.
    PhylomeDBi Q22601.

    Enzyme and pathway databases

    SignaLinki Q22601.

    Miscellaneous databases

    NextBioi 912676.
    PROi Q22601.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1030. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR017104. AP2_complex_asu.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR013038. Clathrin_a-adaptin_app_Ig-like.
    IPR003164. Clathrin_a-adaptin_app_sub_C.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02296. Alpha_adaptin_C. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2Imported.

    Entry informationi

    Entry nameiQ22601_CAEEL
    AccessioniPrimary (citable) accession number: Q22601
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3