Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

T20B5.1

Gene

apa-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activating protein binding Source: WormBase
  • protein C-terminus binding Source: WormBase
  • protein transporter activity Source: InterPro

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • intracellular protein transport Source: InterPro
  • protein localization Source: WormBase
  • receptor-mediated endocytosis Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Protein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiREACT_295497. Recycling pathway of L1.
REACT_299990. Retrograde neurotrophin signalling.
REACT_308285. WNT5A-dependent internalization of FZD4.
SignaLinkiQ22601.

Names & Taxonomyi

Protein namesi
Submitted name:
T20B5.1Imported
Gene namesi
Name:apa-2Imported
ORF Names:CELE_T20B5.1Imported, T20B5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT20B5.1; CE28680; WBGene00000161; apa-2.

Subcellular locationi

GO - Cellular componenti

  • clathrin adaptor complex Source: InterPro
  • clathrin-coated endocytic vesicle Source: WormBase
  • endocytic vesicle Source: WormBase
  • plasma membrane Source: WormBase
  • presynaptic periactive zone Source: WormBase
  • synapse Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22601.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rme-4G5ECW93EBI-5323248,EBI-315316
rme-6Q9GYH73EBI-5323248,EBI-320814

Protein-protein interaction databases

IntActiQ22601. 2 interactions.
STRINGi6239.T20B5.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ22601.
SMRiQ22601. Positions 5-613, 682-925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00550000074757.
HOGENOMiHOG000170596.
InParanoidiQ22601.
KOiK11824.
OMAiSKLILEC.
OrthoDBiEOG7GQXV2.
PhylomeDBiQ22601.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVKGDGMR GLAVFISDIR NCKSKEAELK RINKELANIR SKFKGDKTLD
60 70 80 90 100
GYQKKKYVCK LLFIFLLGND IDFGHMEAVN LLSSNKYTEK QIGYLFISVL
110 120 130 140 150
IEQQSDLMKL IVQGIRNDLT SRNPVHVNLA LQCISNMGSR EMVEAFCTDL
160 170 180 190 200
PKLLVSGETI DFVKQSAALC ILKLFRNSPD SFQPGDYASR IVHLLNDSHM
210 220 230 240 250
GVVTSAASLI EALSKKWPEE YKGAVPLAIS RLSRIVTATY TDLQDYTYYF
260 270 280 290 300
VPAPWLCVKL LRLLQNYPPP DDPSNKARLL ECLEGILNKA QDAPKSKKVQ
310 320 330 340 350
HSNAKNAVLF EAIALIIHMD SEPQLLVRAC NQLGTFLSHR ETNLRYLALE
360 370 380 390 400
SMCLLATSEF SHDAVKKHQD TIINSLKTER DVSVRQRAVD LLYAMCDRSN
410 420 430 440 450
ANQIVAEMLA YLETADYSIR EEMVLKVAIL AEKYATDYTW YVDVILKLIR
460 470 480 490 500
IAGDYVSEEV WYRVIQIVVN REDVQGYAAK TVFEALQRPA CHENMVKVGG
510 520 530 540 550
YILGEFGNFI AGDERSTAKI QFELLHSKFH LCSITTRCLL LTTYIKFCNL
560 570 580 590 600
FPEIKPLVQQ VFQTDHNLRN PDAELQQRSI EYLQMTKLAS NDVLATILEV
610 620 630 640 650
MPAFAEKESS LLAKLKKSKP QLEEIEREEK EKRSKPTAVM SEGSTSLVDF
660 670 680 690 700
DSTNDTTASL ADVFANNSGT GLGAQGDEVE IANKDDYLKF VTKSNAILWE
710 720 730 740 750
DDYIQIGCKL ETRNNLGRLG MFYGNKTSQP FNKFTPIITC PGALAVQLQA
760 770 780 790 800
QAKPVEPVVA AGTQVQQLIN FVCVQEFQKM PIMNIKFTFT DRAGAVQNFD
810 820 830 840 850
KNFYLPLFIS KFFEPTNMTS EQFFTRWKSL GAASQEAQKI FNALSPIEHA
860 870 880 890 900
TIESRLKGFG ANLLTDVDPN PDNYVCAGII HTQTQQIGTL IRLEPNKQAK
910 920
MYRLTIRSSK DTVVQTLVDL LGNQF
Length:925
Mass (Da):104,180
Last modified:October 1, 2001 - v2
Checksum:iA816ADC042FD557C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD68583.1.
PIRiT16911.
RefSeqiNP_509572.1. NM_077171.6.
UniGeneiCel.16972.

Genome annotation databases

EnsemblMetazoaiT20B5.1.1; T20B5.1.1; WBGene00000161.
T20B5.1.2; T20B5.1.2; WBGene00000161.
GeneIDi181163.
KEGGicel:CELE_T20B5.1.
UCSCiT20B5.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CCD68583.1.
PIRiT16911.
RefSeqiNP_509572.1. NM_077171.6.
UniGeneiCel.16972.

3D structure databases

ProteinModelPortaliQ22601.
SMRiQ22601. Positions 5-613, 682-925.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22601. 2 interactions.
STRINGi6239.T20B5.1.1.

Proteomic databases

PaxDbiQ22601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT20B5.1.1; T20B5.1.1; WBGene00000161.
T20B5.1.2; T20B5.1.2; WBGene00000161.
GeneIDi181163.
KEGGicel:CELE_T20B5.1.
UCSCiT20B5.1.1. c. elegans.

Organism-specific databases

CTDi181163.
WormBaseiT20B5.1; CE28680; WBGene00000161; apa-2.

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00550000074757.
HOGENOMiHOG000170596.
InParanoidiQ22601.
KOiK11824.
OMAiSKLILEC.
OrthoDBiEOG7GQXV2.
PhylomeDBiQ22601.

Enzyme and pathway databases

ReactomeiREACT_295497. Recycling pathway of L1.
REACT_299990. Retrograde neurotrophin signalling.
REACT_308285. WNT5A-dependent internalization of FZD4.
SignaLinkiQ22601.

Miscellaneous databases

NextBioi912676.
PROiQ22601.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22601_CAEEL
AccessioniPrimary (citable) accession number: Q22601
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2001
Last modified: June 24, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.