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Q22601

- Q22601_CAEEL

UniProt

Q22601 - Q22601_CAEEL

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Protein
Submitted name:

Protein APA-2

Gene

apa-2

Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activating protein binding Source: WormBase
  2. protein C-terminus binding Source: WormBase
  3. protein transporter activity Source: InterPro

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. intracellular protein transport Source: InterPro
  3. protein localization Source: WormBase
  4. receptor-mediated endocytosis Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Protein transportSAAS annotation, Transport

Enzyme and pathway databases

ReactomeiREACT_238109. Recycling pathway of L1.
REACT_240147. Retrograde neurotrophin signalling.
REACT_259595. WNT5A-dependent internalization of FZD4.
SignaLinkiQ22601.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein APA-2Imported
Gene namesi
Name:apa-2Imported
ORF Names:CELE_T20B5.1Imported, T20B5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiT20B5.1; CE28680; WBGene00000161; apa-2.

Subcellular locationi

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. clathrin-coated endocytic vesicle Source: WormBase
  3. endocytic vesicle Source: WormBase
  4. plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22601.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rme-4G5ECW93EBI-5323248,EBI-315316
rme-6Q9GYH73EBI-5323248,EBI-320814

Protein-protein interaction databases

IntActiQ22601. 2 interactions.
STRINGi6239.T20B5.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ22601.
SMRiQ22601. Positions 5-613, 682-925.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00550000074757.
HOGENOMiHOG000170596.
InParanoidiQ22601.
KOiK11824.
OMAiWVIGGKD.
OrthoDBiEOG7GQXV2.
PhylomeDBiQ22601.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22601-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAVKGDGMR GLAVFISDIR NCKSKEAELK RINKELANIR SKFKGDKTLD
60 70 80 90 100
GYQKKKYVCK LLFIFLLGND IDFGHMEAVN LLSSNKYTEK QIGYLFISVL
110 120 130 140 150
IEQQSDLMKL IVQGIRNDLT SRNPVHVNLA LQCISNMGSR EMVEAFCTDL
160 170 180 190 200
PKLLVSGETI DFVKQSAALC ILKLFRNSPD SFQPGDYASR IVHLLNDSHM
210 220 230 240 250
GVVTSAASLI EALSKKWPEE YKGAVPLAIS RLSRIVTATY TDLQDYTYYF
260 270 280 290 300
VPAPWLCVKL LRLLQNYPPP DDPSNKARLL ECLEGILNKA QDAPKSKKVQ
310 320 330 340 350
HSNAKNAVLF EAIALIIHMD SEPQLLVRAC NQLGTFLSHR ETNLRYLALE
360 370 380 390 400
SMCLLATSEF SHDAVKKHQD TIINSLKTER DVSVRQRAVD LLYAMCDRSN
410 420 430 440 450
ANQIVAEMLA YLETADYSIR EEMVLKVAIL AEKYATDYTW YVDVILKLIR
460 470 480 490 500
IAGDYVSEEV WYRVIQIVVN REDVQGYAAK TVFEALQRPA CHENMVKVGG
510 520 530 540 550
YILGEFGNFI AGDERSTAKI QFELLHSKFH LCSITTRCLL LTTYIKFCNL
560 570 580 590 600
FPEIKPLVQQ VFQTDHNLRN PDAELQQRSI EYLQMTKLAS NDVLATILEV
610 620 630 640 650
MPAFAEKESS LLAKLKKSKP QLEEIEREEK EKRSKPTAVM SEGSTSLVDF
660 670 680 690 700
DSTNDTTASL ADVFANNSGT GLGAQGDEVE IANKDDYLKF VTKSNAILWE
710 720 730 740 750
DDYIQIGCKL ETRNNLGRLG MFYGNKTSQP FNKFTPIITC PGALAVQLQA
760 770 780 790 800
QAKPVEPVVA AGTQVQQLIN FVCVQEFQKM PIMNIKFTFT DRAGAVQNFD
810 820 830 840 850
KNFYLPLFIS KFFEPTNMTS EQFFTRWKSL GAASQEAQKI FNALSPIEHA
860 870 880 890 900
TIESRLKGFG ANLLTDVDPN PDNYVCAGII HTQTQQIGTL IRLEPNKQAK
910 920
MYRLTIRSSK DTVVQTLVDL LGNQF
Length:925
Mass (Da):104,180
Last modified:October 1, 2001 - v2
Checksum:iA816ADC042FD557C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081025 Genomic DNA. Translation: CCD68583.1.
PIRiT16911.
RefSeqiNP_509572.1. NM_077171.6.
UniGeneiCel.16972.

Genome annotation databases

EnsemblMetazoaiT20B5.1.1; T20B5.1.1; WBGene00000161.
T20B5.1.2; T20B5.1.2; WBGene00000161.
GeneIDi181163.
KEGGicel:CELE_T20B5.1.
UCSCiT20B5.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081025 Genomic DNA. Translation: CCD68583.1 .
PIRi T16911.
RefSeqi NP_509572.1. NM_077171.6.
UniGenei Cel.16972.

3D structure databases

ProteinModelPortali Q22601.
SMRi Q22601. Positions 5-613, 682-925.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q22601. 2 interactions.
STRINGi 6239.T20B5.1.1.

Proteomic databases

PaxDbi Q22601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T20B5.1.1 ; T20B5.1.1 ; WBGene00000161 .
T20B5.1.2 ; T20B5.1.2 ; WBGene00000161 .
GeneIDi 181163.
KEGGi cel:CELE_T20B5.1.
UCSCi T20B5.1.1. c. elegans.

Organism-specific databases

CTDi 181163.
WormBasei T20B5.1 ; CE28680 ; WBGene00000161 ; apa-2.

Phylogenomic databases

eggNOGi NOG303101.
GeneTreei ENSGT00550000074757.
HOGENOMi HOG000170596.
InParanoidi Q22601.
KOi K11824.
OMAi WVIGGKD.
OrthoDBi EOG7GQXV2.
PhylomeDBi Q22601.

Enzyme and pathway databases

Reactomei REACT_238109. Recycling pathway of L1.
REACT_240147. Retrograde neurotrophin signalling.
REACT_259595. WNT5A-dependent internalization of FZD4.
SignaLinki Q22601.

Miscellaneous databases

NextBioi 912676.
PROi Q22601.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
SMARTi SM00809. Alpha_adaptinC2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22601_CAEEL
AccessioniPrimary (citable) accession number: Q22601
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3