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Q22601

- Q22601_CAEEL

UniProt

Q22601 - Q22601_CAEEL

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Protein
Submitted name:

Protein APA-2

Gene
apa-2, CELE_T20B5.1, T20B5.1
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. GTPase activating protein binding Source: WormBase
  2. protein binding Source: IntAct
  3. protein C-terminus binding Source: WormBase
  4. protein transporter activity Source: InterPro

GO - Biological processi

  1. embryo development ending in birth or egg hatching Source: WormBase
  2. intracellular protein transport Source: InterPro
  3. protein localization Source: WormBase
  4. receptor-mediated endocytosis Source: WormBase
Complete GO annotation...

Keywords - Biological processi

Protein transportSAAS annotations, Transport

Enzyme and pathway databases

SignaLinkiQ22601.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein APA-2Imported
Gene namesi
Name:apa-2Imported
ORF Names:CELE_T20B5.1Imported, T20B5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiT20B5.1; CE28680; WBGene00000161; apa-2.

Subcellular locationi

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. clathrin-coated endocytic vesicle Source: WormBase
  3. endocytic vesicle Source: WormBase
  4. plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

MembraneSAAS annotations

PTM / Processingi

Proteomic databases

PaxDbiQ22601.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rme-4G5ECW93EBI-5323248,EBI-315316
rme-6Q9GYH73EBI-5323248,EBI-320814

Protein-protein interaction databases

IntActiQ22601. 2 interactions.
STRINGi6239.T20B5.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ22601.
SMRiQ22601. Positions 5-613, 682-925.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG303101.
GeneTreeiENSGT00550000074757.
HOGENOMiHOG000170596.
InParanoidiQ22601.
KOiK11824.
OMAiWVIGGKD.
OrthoDBiEOG7GQXV2.
PhylomeDBiQ22601.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view]
PfamiPF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view]
PIRSFiPIRSF037091. AP2_complex_alpha. 1 hit.
SMARTiSM00809. Alpha_adaptinC2. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22601-1 [UniParc]FASTAAdd to Basket

« Hide

MPAVKGDGMR GLAVFISDIR NCKSKEAELK RINKELANIR SKFKGDKTLD    50
GYQKKKYVCK LLFIFLLGND IDFGHMEAVN LLSSNKYTEK QIGYLFISVL 100
IEQQSDLMKL IVQGIRNDLT SRNPVHVNLA LQCISNMGSR EMVEAFCTDL 150
PKLLVSGETI DFVKQSAALC ILKLFRNSPD SFQPGDYASR IVHLLNDSHM 200
GVVTSAASLI EALSKKWPEE YKGAVPLAIS RLSRIVTATY TDLQDYTYYF 250
VPAPWLCVKL LRLLQNYPPP DDPSNKARLL ECLEGILNKA QDAPKSKKVQ 300
HSNAKNAVLF EAIALIIHMD SEPQLLVRAC NQLGTFLSHR ETNLRYLALE 350
SMCLLATSEF SHDAVKKHQD TIINSLKTER DVSVRQRAVD LLYAMCDRSN 400
ANQIVAEMLA YLETADYSIR EEMVLKVAIL AEKYATDYTW YVDVILKLIR 450
IAGDYVSEEV WYRVIQIVVN REDVQGYAAK TVFEALQRPA CHENMVKVGG 500
YILGEFGNFI AGDERSTAKI QFELLHSKFH LCSITTRCLL LTTYIKFCNL 550
FPEIKPLVQQ VFQTDHNLRN PDAELQQRSI EYLQMTKLAS NDVLATILEV 600
MPAFAEKESS LLAKLKKSKP QLEEIEREEK EKRSKPTAVM SEGSTSLVDF 650
DSTNDTTASL ADVFANNSGT GLGAQGDEVE IANKDDYLKF VTKSNAILWE 700
DDYIQIGCKL ETRNNLGRLG MFYGNKTSQP FNKFTPIITC PGALAVQLQA 750
QAKPVEPVVA AGTQVQQLIN FVCVQEFQKM PIMNIKFTFT DRAGAVQNFD 800
KNFYLPLFIS KFFEPTNMTS EQFFTRWKSL GAASQEAQKI FNALSPIEHA 850
TIESRLKGFG ANLLTDVDPN PDNYVCAGII HTQTQQIGTL IRLEPNKQAK 900
MYRLTIRSSK DTVVQTLVDL LGNQF 925
Length:925
Mass (Da):104,180
Last modified:October 1, 2001 - v2
Checksum:iA816ADC042FD557C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081025 Genomic DNA. Translation: CCD68583.1.
PIRiT16911.
RefSeqiNP_509572.1. NM_077171.6.
UniGeneiCel.16972.

Genome annotation databases

EnsemblMetazoaiT20B5.1.1; T20B5.1.1; WBGene00000161.
T20B5.1.2; T20B5.1.2; WBGene00000161.
GeneIDi181163.
KEGGicel:CELE_T20B5.1.
UCSCiT20B5.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081025 Genomic DNA. Translation: CCD68583.1 .
PIRi T16911.
RefSeqi NP_509572.1. NM_077171.6.
UniGenei Cel.16972.

3D structure databases

ProteinModelPortali Q22601.
SMRi Q22601. Positions 5-613, 682-925.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q22601. 2 interactions.
STRINGi 6239.T20B5.1.1.

Proteomic databases

PaxDbi Q22601.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T20B5.1.1 ; T20B5.1.1 ; WBGene00000161 .
T20B5.1.2 ; T20B5.1.2 ; WBGene00000161 .
GeneIDi 181163.
KEGGi cel:CELE_T20B5.1.
UCSCi T20B5.1.1. c. elegans.

Organism-specific databases

CTDi 181163.
WormBasei T20B5.1 ; CE28680 ; WBGene00000161 ; apa-2.

Phylogenomic databases

eggNOGi NOG303101.
GeneTreei ENSGT00550000074757.
HOGENOMi HOG000170596.
InParanoidi Q22601.
KOi K11824.
OMAi WVIGGKD.
OrthoDBi EOG7GQXV2.
PhylomeDBi Q22601.

Enzyme and pathway databases

SignaLinki Q22601.

Miscellaneous databases

NextBioi 912676.
PROi Q22601.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1030. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR017104. AP2_complex_asu.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR013038. Clathrin_a-adaptin_app_Ig-like.
IPR003164. Clathrin_a-adaptin_app_sub_C.
IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
[Graphical view ]
Pfami PF01602. Adaptin_N. 1 hit.
PF02296. Alpha_adaptin_C. 1 hit.
PF02883. Alpha_adaptinC2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037091. AP2_complex_alpha. 1 hit.
SMARTi SM00809. Alpha_adaptinC2. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiQ22601_CAEEL
AccessioniPrimary (citable) accession number: Q22601
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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