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Protein

Importin subunit alpha-1

Gene

ima-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).By similarity

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • protein import into nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-1
Alternative name(s):
Karyopherin subunit alpha-1
Gene namesi
Name:ima-1
ORF Names:T19B10.7
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT19B10.7; CE06461; WBGene00002072; ima-1.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nuclear pore Source: UniProtKB
  • nucleoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Importin subunit alpha-1PRO_0000120734Add
BLAST

Proteomic databases

PaxDbiQ22560.

PTM databases

iPTMnetiQ22560.

Expressioni

Tissue specificityi

Adult germline tissues.1 Publication

Developmental stagei

Expressed very weakly in early larvae, levels of expression increase in L4 and adult stages when germ cells are continually proliferating.1 Publication

Interactioni

Subunit structurei

Forms a complex with an importin beta subunit.1 Publication

Protein-protein interaction databases

BioGridi44582. 2 interactions.
IntActiQ22560. 1 interaction.
MINTiMINT-6668514.
STRINGi6239.T19B10.7.1.

Structurei

3D structure databases

ProteinModelPortaliQ22560.
SMRiQ22560. Positions 189-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5959IBBPROSITE-ProRule annotationAdd
BLAST

Domaini

Does not contain ARM repeats, but instead Ser charged repeats. May have specificity for cargos distinct from that of other importin alpha subunits.

Sequence similaritiesi

Belongs to the importin alpha family.Curated
Contains 1 IBB domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOGENOMiHOG000022551.
InParanoidiQ22560.
OMAiISNICVE.
PhylomeDBiQ22560.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR002652. Importin-a_IBB.
[Graphical view]
PfamiPF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEFRPSHE ERSKMYKSNV RDQNEMRRKR REDEVQIRKN RRDEKFERNR
60 70 80 90 100
QITVQRSLSH EETSELLKSV ADGLQSMQET TIHEALTVLH ENLNNTVWTI
110 120 130 140 150
HVLVKVQILH KLSDVYCNRV ISQTTRLLIS RTLLKISGID EVKYERYSSD
160 170 180 190 200
DRCIQSLVFN ISTYGSSEDI LCDTFQSIAC FIIRSITYRN LALDCAIVSE
210 220 230 240 250
LIDASTINMS IILHRSLMWL VFLFCEKLDR CSPHVDEIAP LLEIISNGIQ
260 270 280 290 300
STDAMVQTDA ASSCASLAEW PPIYHYMSDL KLCSKLVANL RNDKGNARPK
310 320 330 340 350
VKAGINSIIQ ATGYFTEEMI DAGLLEVLKG FVNVSYMSQE VCFIISNICV
360 370 380 390 400
EGEQTIDKLI SSGVLREVAR VMEASEYRSR REAAFVICHC CASANQKHLE
410 420 430 440 450
YVVELGMLSA FTDLLTCMDV SLVSYILDAI YLLLQFGEMR LLPDNSNPVA
460 470 480 490 500
IKLEEIGCRE KLEFLCESQS VDIHARAYTI IDRFYVDDDA PLNDDPFAGY
510 520
QRNNIDDTIE KMIREPIMDQ PFSF
Length:524
Mass (Da):59,925
Last modified:November 1, 1996 - v1
Checksum:iC2DBBE2437859FA7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831H → Q in AAB97173 (PubMed:11311162).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040997 mRNA. Translation: AAB97173.1.
Z74043 Genomic DNA. Translation: CAA98540.1.
PIRiT24976.
T42404.
RefSeqiNP_505854.1. NM_073453.6.
UniGeneiCel.5447.

Genome annotation databases

EnsemblMetazoaiT19B10.7.1; T19B10.7.1; WBGene00002072.
T19B10.7.2; T19B10.7.2; WBGene00002072.
GeneIDi179555.
KEGGicel:CELE_T19B10.7.
UCSCiT19B10.7.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040997 mRNA. Translation: AAB97173.1.
Z74043 Genomic DNA. Translation: CAA98540.1.
PIRiT24976.
T42404.
RefSeqiNP_505854.1. NM_073453.6.
UniGeneiCel.5447.

3D structure databases

ProteinModelPortaliQ22560.
SMRiQ22560. Positions 189-485.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44582. 2 interactions.
IntActiQ22560. 1 interaction.
MINTiMINT-6668514.
STRINGi6239.T19B10.7.1.

PTM databases

iPTMnetiQ22560.

Proteomic databases

PaxDbiQ22560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT19B10.7.1; T19B10.7.1; WBGene00002072.
T19B10.7.2; T19B10.7.2; WBGene00002072.
GeneIDi179555.
KEGGicel:CELE_T19B10.7.
UCSCiT19B10.7.2. c. elegans.

Organism-specific databases

CTDi179555.
WormBaseiT19B10.7; CE06461; WBGene00002072; ima-1.

Phylogenomic databases

eggNOGiKOG0166. Eukaryota.
COG5064. LUCA.
GeneTreeiENSGT00760000119094.
HOGENOMiHOG000022551.
InParanoidiQ22560.
OMAiISNICVE.
PhylomeDBiQ22560.

Miscellaneous databases

PROiQ22560.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032413. Arm_3.
IPR002652. Importin-a_IBB.
[Graphical view]
PfamiPF16186. Arm_3. 1 hit.
PF01749. IBB. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51214. IBB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Germline and developmental roles of the nuclear transport factor importin alpha3 in C. elegans."
    Geles K.G., Adam S.A.
    Development 128:1817-1830(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIMA1_CAEEL
AccessioniPrimary (citable) accession number: Q22560
Secondary accession number(s): O44926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.