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Protein

Importin subunit alpha-1

Gene

ima-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).By similarity

GO - Molecular functioni

  • nuclear import signal receptor activity Source: InterPro
  • nuclear localization sequence binding Source: GO_Central
  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • NLS-bearing protein import into nucleus Source: GO_Central
  • protein import into nucleus Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-1
Alternative name(s):
Karyopherin subunit alpha-1
Gene namesi
Name:ima-1
ORF Names:T19B10.7
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT19B10.7 ; CE06461 ; WBGene00002072 ; ima-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207341 – 524Importin subunit alpha-1Add BLAST524

Proteomic databases

EPDiQ22560
PaxDbiQ22560
PeptideAtlasiQ22560

PTM databases

iPTMnetiQ22560

Expressioni

Tissue specificityi

Adult germline tissues.1 Publication

Developmental stagei

Expressed very weakly in early larvae, levels of expression increase in L4 and adult stages when germ cells are continually proliferating.1 Publication

Gene expression databases

BgeeiWBGene00002072

Interactioni

Subunit structurei

Forms a complex with an importin beta subunit.1 Publication

Protein-protein interaction databases

BioGridi44582, 2 interactors
IntActiQ22560, 1 interactor
STRINGi6239.T19B10.7.1

Structurei

3D structure databases

ProteinModelPortaliQ22560
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59IBBPROSITE-ProRule annotationAdd BLAST59

Domaini

Does not contain ARM repeats, but instead Ser charged repeats. May have specificity for cargos distinct from that of other importin alpha subunits.

Sequence similaritiesi

Belongs to the importin alpha family.Curated

Phylogenomic databases

eggNOGiKOG0166 Eukaryota
COG5064 LUCA
GeneTreeiENSGT00760000119094
HOGENOMiHOG000022551
InParanoidiQ22560
OMAiISNICVE
OrthoDBiEOG091G09EF
PhylomeDBiQ22560

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR032413 Arm_3
IPR002652 Importin-a_IBB
PfamiView protein in Pfam
PF16186 Arm_3, 1 hit
PF01749 IBB, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51214 IBB, 1 hit

Sequencei

Sequence statusi: Complete.

Q22560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEFRPSHE ERSKMYKSNV RDQNEMRRKR REDEVQIRKN RRDEKFERNR
60 70 80 90 100
QITVQRSLSH EETSELLKSV ADGLQSMQET TIHEALTVLH ENLNNTVWTI
110 120 130 140 150
HVLVKVQILH KLSDVYCNRV ISQTTRLLIS RTLLKISGID EVKYERYSSD
160 170 180 190 200
DRCIQSLVFN ISTYGSSEDI LCDTFQSIAC FIIRSITYRN LALDCAIVSE
210 220 230 240 250
LIDASTINMS IILHRSLMWL VFLFCEKLDR CSPHVDEIAP LLEIISNGIQ
260 270 280 290 300
STDAMVQTDA ASSCASLAEW PPIYHYMSDL KLCSKLVANL RNDKGNARPK
310 320 330 340 350
VKAGINSIIQ ATGYFTEEMI DAGLLEVLKG FVNVSYMSQE VCFIISNICV
360 370 380 390 400
EGEQTIDKLI SSGVLREVAR VMEASEYRSR REAAFVICHC CASANQKHLE
410 420 430 440 450
YVVELGMLSA FTDLLTCMDV SLVSYILDAI YLLLQFGEMR LLPDNSNPVA
460 470 480 490 500
IKLEEIGCRE KLEFLCESQS VDIHARAYTI IDRFYVDDDA PLNDDPFAGY
510 520
QRNNIDDTIE KMIREPIMDQ PFSF
Length:524
Mass (Da):59,925
Last modified:November 1, 1996 - v1
Checksum:iC2DBBE2437859FA7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83H → Q in AAB97173 (PubMed:11311162).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040997 mRNA Translation: AAB97173.1
Z74043 Genomic DNA Translation: CAA98540.1
PIRiT24976
T42404
RefSeqiNP_505854.1, NM_073453.6
UniGeneiCel.5447

Genome annotation databases

EnsemblMetazoaiT19B10.7.1; T19B10.7.1; WBGene00002072
T19B10.7.2; T19B10.7.2; WBGene00002072
GeneIDi179555
KEGGicel:CELE_T19B10.7
UCSCiT19B10.7.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiIMA1_CAEEL
AccessioniPrimary (citable) accession number: Q22560
Secondary accession number(s): O44926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health