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Q22460 (BCA1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta carbonic anhydrase 1
EC=4.2.1.1
Gene names
Name:bca-1
ORF Names:T13C5.5
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Reversible hydration of carbon dioxide By similarity.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Binds 1 zinc ion per subunit By similarity. UniProtKB P45148

Subunit structure

Oligomer By similarity. UniProtKB P0ABE9

Sequence similarities

Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Beta carbonic anhydrase 1
PRO_0000374066

Sites

Metal binding391Zinc By similarity UniProtKB P45148
Metal binding411Zinc By similarity UniProtKB P45148
Metal binding1051Zinc By similarity UniProtKB P45148
Metal binding1081Zinc By similarity UniProtKB P45148

Sequences

Sequence LengthMass (Da)Tools
Q22460 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5DCA96F0294A7FE1

FASTA27030,686
        10         20         30         40         50         60 
MNKILRGVIQ FRNTIRKDLV KQFEEIKNNP SPTAVMFTCM DSRMLPTRFT QSQVGDMFVV 

        70         80         90        100        110        120 
RNAGNMIPDA PNYGAFSEVS VNTEPAALEL AVKRGGIRHI VVCGHSDCKA INTLYGLHQC 

       130        140        150        160        170        180 
PKNFDVTSPM DHWVRRNGFA SVKRLNERLH RGPSSMKFES EVAPSQSFDA IIDPMDTLAM 

       190        200        210        220        230        240 
EDKLSQINVL QQLINICSHE FLKEYLESGR LHIHGMWFDI YKGEDYLFSK DKKRFVVIDE 

       250        260        270 
KTVTDLLAEL NARYPVPEDQ DGPVAFAKSN

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080546 Genomic DNA. Translation: CCD64556.1.
PIRT16868.
RefSeqNP_741809.1. NM_171701.3.
UniGeneCel.37586.

3D structure databases

ProteinModelPortalQ22460.
SMRQ22460. Positions 1-238.
ModBaseSearch...

Proteomic databases

PRIDEQ22460.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT13C5.5; T13C5.5; T13C5.5.
GeneID180890.
KEGGcel:T13C5.5.
NMPDRfig|6239.3.peg.23483.

Organism-specific databases

CTD180890.
WormBaseT13C5.5; CE04946; WBGene00000245; bca-1.

Phylogenomic databases

eggNOGmeNOG18450.
GeneTreeEMGT00050000012394.
HOGENOMHBG385000.
InParanoidQ22460.
PhylomeDBQ22460.

Gene expression databases

ArrayExpressQ22460.

Family and domain databases

InterProIPR001765. Carbonic_anhydrase.
[Graphical view]
Gene3DG3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHERPTHR11002. Carbonic_anhydrase. 1 hit.
PfamPF00484. Pro_CA. 1 hit.
[Graphical view]
SMARTSM00947. Pro_CA. 1 hit.
[Graphical view]
SUPFAMSSF53056. Prok_plnt_COanhd. 1 hit.
PROSITEPS00704. PROK_CO2_ANHYDRASE_1. False negative.
PS00705. PROK_CO2_ANHYDRASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio911432.

Entry information

Entry nameBCA1_CAEEL
AccessionPrimary (citable) accession number: Q22460
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

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