Reviewed, UniProtKB/Swiss-Prot Q22460 (BCA1_CAEEL)

Names and origin

Protein names

Recommended name:
    Beta carbonic anhydrase 1
    EC=4.2.1.1

Gene names

Name:	bca-1
ORF Names:	T13C5.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide By similarity.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Binds 1 zinc ion per subunit By similarity. UniProtKB P45148
Subunit structure	Oligomer By similarity. UniProtKB P0ABE9
Sequence similarities	Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbon utilization Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Beta carbonic anhydrase 1		PRO_0000374066
Sites
	Metal binding	39	1	Zinc By similarity UniProtKB P45148
	Metal binding	41	1	Zinc By similarity UniProtKB P45148
	Metal binding	105	1	Zinc By similarity UniProtKB P45148
	Metal binding	108	1	Zinc By similarity UniProtKB P45148

Sequences

	Sequence		Length	Mass (Da)
	Q22460-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5DCA96F0294A7FE1	FASTA	270	30,686
	10 20 30 40 50 60 MNKILRGVIQ FRNTIRKDLV KQFEEIKNNP SPTAVMFTCM DSRMLPTRFT QSQVGDMFVV 70 80 90 100 110 120 RNAGNMIPDA PNYGAFSEVS VNTEPAALEL AVKRGGIRHI VVCGHSDCKA INTLYGLHQC 130 140 150 160 170 180 PKNFDVTSPM DHWVRRNGFA SVKRLNERLH RGPSSMKFES EVAPSQSFDA IIDPMDTLAM 190 200 210 220 230 240 EDKLSQINVL QQLINICSHE FLKEYLESGR LHIHGMWFDI YKGEDYLFSK DKKRFVVIDE 250 260 270 KTVTDLLAEL NARYPVPEDQ DGPVAFAKSN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39648 Genomic DNA. Translation: AAK39291.1.
PIR	T16868.
RefSeq	NP_741809.1.
UniGene	Cel.37586
3D structure databases
SMR	Q22460. Positions 2-237.
ModBase	Search...
Proteomic databases
PRIDE	Q22460.
Genome annotation databases
Ensembl	T13C5.5; T13C5.5; T13C5.5; Caenorhabditis elegans. [Genome view]
GeneID	180890.
KEGG	cel:T13C5.5.
NMPDR	fig|6239.3.peg.23483.
Organism-specific databases
CTD	180890.
WormBase	WBGene00000245. bca-1.
WormPep	T13C5.5. CE04946. [WorfDB]
Phylogenomic databases
eggNOG	meNOG18450.
HOGENOM	HBG385000.
InParanoid	Q22460.
Gene expression databases
ArrayExpress	Q22460.
Family and domain databases
InterPro	IPR001765. Carbonic_anhydrase. [Graphical view]
Gene3D	G3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHER	PTHR11002. Carbonic_anhydrase. 1 hit.
Pfam	PF00484. Pro_CA. 1 hit. [Graphical view]
PROSITE	PS00704. PROK_CO2_ANHYDRASE_1. False negative. PS00705. PROK_CO2_ANHYDRASE_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	911432.

Entry information

Entry name

BCA1_CAEEL

Accession

Primary (citable) accession number: Q22460

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project