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Protein
Submitted name:

GEN1 Holliday junction resolvase homolog

Gene

gen-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • crossover junction endodeoxyribonuclease activity Source: WormBase
  • DNA binding Source: InterPro

GO - Biological processi

  • double-strand break repair via homologous recombination Source: WormBase
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: WormBase
  • negative regulation of nematode larval development Source: UniProtKB
  • signal transduction involved in DNA damage checkpoint Source: WormBase
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-5696395. Formation of Incision Complex in GG-NER.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.

Names & Taxonomyi

Protein namesi
Submitted name:
GEN1 Holliday junction resolvase homologImported
Gene namesi
Name:gen-1Imported
ORF Names:CELE_T12A2.8Imported, T12A2.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT12A2.8; CE01401; WBGene00020442; gen-1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ22418.

Interactioni

Protein-protein interaction databases

STRINGi6239.T12A2.8.2.

Structurei

3D structure databases

ProteinModelPortaliQ22418.
SMRiQ22418. Positions 3-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 100100XPGNInterPro annotationAdd
BLAST
Domaini121 – 19474XPGIInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2519. Eukaryota.
COG0258. LUCA.
GeneTreeiENSGT00640000091542.
HOGENOMiHOG000021109.
InParanoidiQ22418.
OMAiSGCITTD.
PhylomeDBiQ22418.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081. PTHR11081. 1 hit.
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTINGIWEWA NHVVRKVPNE TMRDKTLSID GHIWLYESLK GCEAHHQQTP
60 70 80 90 100
NSYLVTFFTR IQRLLELKII PIVVFDNINA SSSAHESKDQ NEFVPRKRRS
110 120 130 140 150
FGDSPFTNLV DHVYKTNALL TELGIKVIIA PGDGEAQCAR LEDLGVTSGC
160 170 180 190 200
ITTDFDYFLF GGKNLYRFDF TAGTSSTACL HDIMHLSLGR MFMEKKVSRP
210 220 230 240 250
HLISTAILLG CDYFQRGVQN IGIVSVFDIL GEFGDDGNEE IDPHVILDRF
260 270 280 290 300
ASYVREEIPA RSEDTQRKLR LRRKKYNFPV GFPNCDAVHN AITMYLRPPV
310 320 330 340 350
SSEIPKIIPR AANFQQVAEI MMKECGWPAT RTQKELALSI RRKVHLTTTV
360 370 380 390 400
AQTRIPDFFA ATKSKNFTPI VEPCESLEDY ISANNTWMRK RKRSESPQIL
410 420 430
QHHAKRQVPD RKRSVKIRAF KPYPTDVIEL GDSD
Length:434
Mass (Da):49,576
Last modified:November 1, 1996 - v1
Checksum:i60ACCC27C83C3265
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD65214.1.
PIRiT34350.
RefSeqiNP_498361.1. NM_065960.3.
UniGeneiCel.7673.

Genome annotation databases

EnsemblMetazoaiT12A2.8.1; T12A2.8.1; WBGene00020442.
T12A2.8.2; T12A2.8.2; WBGene00020442.
GeneIDi175885.
KEGGicel:CELE_T12A2.8.
UCSCiT12A2.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD65214.1.
PIRiT34350.
RefSeqiNP_498361.1. NM_065960.3.
UniGeneiCel.7673.

3D structure databases

ProteinModelPortaliQ22418.
SMRiQ22418. Positions 3-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T12A2.8.2.

Proteomic databases

PaxDbiQ22418.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT12A2.8.1; T12A2.8.1; WBGene00020442.
T12A2.8.2; T12A2.8.2; WBGene00020442.
GeneIDi175885.
KEGGicel:CELE_T12A2.8.
UCSCiT12A2.8.1. c. elegans.

Organism-specific databases

CTDi175885.
WormBaseiT12A2.8; CE01401; WBGene00020442; gen-1.

Phylogenomic databases

eggNOGiKOG2519. Eukaryota.
COG0258. LUCA.
GeneTreeiENSGT00640000091542.
HOGENOMiHOG000021109.
InParanoidiQ22418.
OMAiSGCITTD.
PhylomeDBiQ22418.

Enzyme and pathway databases

ReactomeiR-CEL-5696395. Formation of Incision Complex in GG-NER.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-6782135. Dual incision in TC-NER.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR11081. PTHR11081. 1 hit.
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22418_CAEEL
AccessioniPrimary (citable) accession number: Q22418
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.