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Protein

Zinc metalloproteinase nas-21

Gene

nas-21

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential metalloprotease.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381By similarity
Metal bindingi141 – 1411Zinc; catalyticBy similarity
Metal bindingi147 – 1471Zinc; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A43.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-21 (EC:3.4.24.-)
Alternative name(s):
Nematode astacin 21
Gene namesi
Name:nas-21
ORF Names:T11F9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT11F9.5; CE41929; WBGene00003540; nas-21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 380356Zinc metalloproteinase nas-21PRO_0000028925Add
BLAST

Proteomic databases

PaxDbiQ22401.

Structurei

3D structure databases

ProteinModelPortaliQ22401.
SMRiQ22401. Positions 39-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000016719.
InParanoidiQ22401.
OMAiMTSPRAC.
PhylomeDBiQ22401.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR031067. Nas-21/nas-22.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10127:SF620. PTHR10127:SF620. 2 hits.
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYFITFFFM HIAVLNFYFR FSNGNKIVMR VGGSPETKRL ERSKRQALRM
60 70 80 90 100
DNEPRWPRGT INYFFDEQRF DENSRATVLR AMEKISNHTC IKFSPKDARI
110 120 130 140 150
KLRIVSDKGC QAAIGRVGGD QQYLSFPTSC YSVGSASELI HVIGFLHSHQ
160 170 180 190 200
RADRDEYLKL NLQPWRLNDW FQTMQYKKYL DQWWIVPYDY GSIMQYHDSD
210 220 230 240 250
NEYGPKNSKY FRTMGSQIPS YFDYLMINEY YQCSCEGEEQ INCKNRGYPN
260 270 280 290 300
PGNCSECNCP LESSEEWKNI TLNLDAGYMS LQNGTKLHQI DFVFRYLSIS
310 320 330 340 350
APANKTIEVD IREITGVECN YGCYIGGIEV KTHEDRRMTS PRLCCKNDNE
360 370 380
IYKSRNNPTI VMAFNSEGLD KYNIFYRFTD
Length:380
Mass (Da):44,626
Last modified:April 8, 2008 - v3
Checksum:i65B2877F3F384D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA. Translation: CAA98533.2.
AJ561211 mRNA. Translation: CAD99213.1.
PIRiT24841.
RefSeqiNP_505907.2. NM_073506.4.
UniGeneiCel.2326.

Genome annotation databases

EnsemblMetazoaiT11F9.5; T11F9.5; WBGene00003540.
GeneIDi188422.
KEGGicel:CELE_T11F9.5.
UCSCiT11F9.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA. Translation: CAA98533.2.
AJ561211 mRNA. Translation: CAD99213.1.
PIRiT24841.
RefSeqiNP_505907.2. NM_073506.4.
UniGeneiCel.2326.

3D structure databases

ProteinModelPortaliQ22401.
SMRiQ22401. Positions 39-234.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.A43.

Proteomic databases

PaxDbiQ22401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT11F9.5; T11F9.5; WBGene00003540.
GeneIDi188422.
KEGGicel:CELE_T11F9.5.
UCSCiT11F9.5. c. elegans.

Organism-specific databases

CTDi188422.
WormBaseiT11F9.5; CE41929; WBGene00003540; nas-21.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000016719.
InParanoidiQ22401.
OMAiMTSPRAC.
PhylomeDBiQ22401.

Miscellaneous databases

PROiQ22401.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR031067. Nas-21/nas-22.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10127:SF620. PTHR10127:SF620. 2 hits.
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The astacin protein family in Caenorhabditis elegans."
    Moehrlen F., Hutter H., Zwilling R.
    Eur. J. Biochem. 270:4909-4920(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 157-238, GENE STRUCTURE, NOMENCLATURE.
    Strain: Bristol N2.

Entry informationi

Entry nameiNAS21_CAEEL
AccessioniPrimary (citable) accession number: Q22401
Secondary accession number(s): Q7Z0M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Ser-137 is present instead of the conserved His which is expected to be zinc-binding residue. There is therefore some uncertainty concerning the enzymatic activity of this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.