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Protein

Zinc metalloproteinase-like protein nas-21

Gene

nas-21

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May lack metalloprotease activity.Curated

Caution

Ser-137 is present instead of the conserved His which is expected to be zinc-binding residue. There is therefore some uncertainty concerning the enzymatic activity of this protein.Curated

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPSiM12.A43

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-like protein nas-21Curated
Alternative name(s):
Nematode astacin 21
Gene namesi
Name:nas-21
ORF Names:T11F9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT11F9.5 ; CE41929 ; WBGene00003540 ; nas-21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028925? – 380Zinc metalloproteinase-like protein nas-21
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000044266825 – ?Curated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi253N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi269N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi283N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi304N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ22401

Expressioni

Gene expression databases

BgeeiWBGene00003540

Interactioni

Protein-protein interaction databases

STRINGi6239.T11F9.5

Structurei

3D structure databases

ProteinModelPortaliQ22401
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
HOGENOMiHOG000016719
InParanoidiQ22401
OMAiMTSPRAC
OrthoDBiEOG091G0H9G
PhylomeDBiQ22401

Family and domain databases

CDDicd04280 ZnMc_astacin_like, 1 hit
Gene3Di3.40.390.101 hit
InterProiView protein in InterPro
IPR034035 Astacin-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR017050 Metallopeptidase_nem
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PIRSFiPIRSF036365 Astacin_nematoda, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYFITFFFM HIAVLNFYFR FSNGNKIVMR VGGSPETKRL ERSKRQALRM
60 70 80 90 100
DNEPRWPRGT INYFFDEQRF DENSRATVLR AMEKISNHTC IKFSPKDARI
110 120 130 140 150
KLRIVSDKGC QAAIGRVGGD QQYLSFPTSC YSVGSASELI HVIGFLHSHQ
160 170 180 190 200
RADRDEYLKL NLQPWRLNDW FQTMQYKKYL DQWWIVPYDY GSIMQYHDSD
210 220 230 240 250
NEYGPKNSKY FRTMGSQIPS YFDYLMINEY YQCSCEGEEQ INCKNRGYPN
260 270 280 290 300
PGNCSECNCP LESSEEWKNI TLNLDAGYMS LQNGTKLHQI DFVFRYLSIS
310 320 330 340 350
APANKTIEVD IREITGVECN YGCYIGGIEV KTHEDRRMTS PRLCCKNDNE
360 370 380
IYKSRNNPTI VMAFNSEGLD KYNIFYRFTD
Length:380
Mass (Da):44,626
Last modified:April 8, 2008 - v3
Checksum:i65B2877F3F384D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA Translation: CAA98533.2
AJ561211 mRNA Translation: CAD99213.1
PIRiT24841
RefSeqiNP_505907.2, NM_073506.4
UniGeneiCel.2326

Genome annotation databases

EnsemblMetazoaiT11F9.5; T11F9.5; WBGene00003540
GeneIDi188422
KEGGicel:CELE_T11F9.5
UCSCiT11F9.5 c. elegans

Entry informationi

Entry nameiNAS21_CAEEL
AccessioniPrimary (citable) accession number: Q22401
Secondary accession number(s): Q7Z0M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome