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Protein

Zinc metalloproteinase nas-22

Gene

nas-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi138 – 1381Zinc; catalyticPROSITE-ProRule annotation
Active sitei139 – 1391PROSITE-ProRule annotation
Metal bindingi142 – 1421Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi148 – 1481Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A43.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-22 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 22
Gene namesi
Name:nas-22
ORF Names:T11F9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT11F9.6; CE44156; WBGene00003541; nas-22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 367351Zinc metalloproteinase nas-22PRO_0000028926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi236 ↔ 244By similarity
Disulfide bondi238 ↔ 258By similarity
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence analysis
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi260 ↔ 269By similarity
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence analysis
Glycosylationi322 – 3221N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ22398.

Expressioni

Gene expression databases

BgeeiWBGene00003541.

Interactioni

Protein-protein interaction databases

BioGridi53089. 1 interaction.
DIPiDIP-26108N.
MINTiMINT-1092334.
STRINGi6239.T11F9.6.

Structurei

3D structure databases

ProteinModelPortaliQ22398.
SMRiQ22398. Positions 56-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini232 – 27039EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
InParanoidiQ22398.
OMAiINKYYEC.
OrthoDBiEOG091G0FPC.
PhylomeDBiQ22398.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR031067. Nas-21/nas-22.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10127:SF620. PTHR10127:SF620. 2 hits.
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFFILLSI LQECYGKDIV ARIGGRNVAE KIGGARHRRQ VLIRGSDEER
60 70 80 90 100
RHKWFNNTVH YYFYEENFDF TVKESILRAM ELISNHTCIK FSTEPSEKSI
110 120 130 140 150
RMESDSTTIA CYAEIGQVRE NQLFSFNSDC YSAGVAVHEL IHSLGFIHAH
160 170 180 190 200
QRSDRDQYLE FKKNLDELNQ TYQEQYKIWE YQEILVPYDV GSVMQYPNEE
210 220 230 240 250
DEEYYPVRKY RTMANTMGSA IVAFYDYLMI NKYYECSCAN NLSCKNHGYP
260 270 280 290 300
NPSNCSQCNC PYGFGGADCS QRAEPGATFQ ATETWQNVTI SLDAGYRYLE
310 320 330 340 350
NNQKLPQVDF IYQFLWIMAP ANKTTQIRVE KFVEGKCLPG CIRGGVEIKT
360
NEDPRLTSPR LCCEETS
Length:367
Mass (Da):42,514
Last modified:March 23, 2010 - v3
Checksum:i56D8AAE1B5F497F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA. Translation: CAA98530.2.
AJ561212 mRNA. Translation: CAE47484.1.
PIRiT24838.
RefSeqiNP_505908.2. NM_073507.3.
UniGeneiCel.2323.

Genome annotation databases

EnsemblMetazoaiT11F9.6; T11F9.6; WBGene00003541.
GeneIDi188423.
KEGGicel:CELE_T11F9.6.
UCSCiT11F9.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA. Translation: CAA98530.2.
AJ561212 mRNA. Translation: CAE47484.1.
PIRiT24838.
RefSeqiNP_505908.2. NM_073507.3.
UniGeneiCel.2323.

3D structure databases

ProteinModelPortaliQ22398.
SMRiQ22398. Positions 56-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi53089. 1 interaction.
DIPiDIP-26108N.
MINTiMINT-1092334.
STRINGi6239.T11F9.6.

Protein family/group databases

MEROPSiM12.A43.

Proteomic databases

PaxDbiQ22398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT11F9.6; T11F9.6; WBGene00003541.
GeneIDi188423.
KEGGicel:CELE_T11F9.6.
UCSCiT11F9.6. c. elegans.

Organism-specific databases

CTDi188423.
WormBaseiT11F9.6; CE44156; WBGene00003541; nas-22.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
InParanoidiQ22398.
OMAiINKYYEC.
OrthoDBiEOG091G0FPC.
PhylomeDBiQ22398.

Miscellaneous databases

PROiQ22398.

Gene expression databases

BgeeiWBGene00003541.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR017050. Metallopeptidase_nem.
IPR031067. Nas-21/nas-22.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PANTHERiPTHR10127:SF620. PTHR10127:SF620. 2 hits.
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PIRSFiPIRSF036365. Astacin_nematoda. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS22_CAEEL
AccessioniPrimary (citable) accession number: Q22398
Secondary accession number(s): Q70MS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 23, 2010
Last modified: September 7, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.