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Protein

Zinc metalloproteinase nas-22

Gene

nas-22

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metalloprotease.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi138Zinc; catalyticPROSITE-ProRule annotation1
Active sitei139PROSITE-ProRule annotation1
Metal bindingi142Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi148Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM12.A43

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-22 (EC:3.4.24.-By similarity)
Alternative name(s):
Nematode astacin 22
Gene namesi
Name:nas-22
ORF Names:T11F9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT11F9.6 ; CE44156 ; WBGene00003541 ; nas-22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000028926? – 367Zinc metalloproteinase nas-22
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000044266917 – ?Curated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi236 ↔ 244By similarity
Disulfide bondi238 ↔ 258By similarity
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi260 ↔ 269By similarity
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ22398

Expressioni

Tissue specificityi

Expressed in uterine seam (utse) cell.1 Publication

Gene expression databases

BgeeiWBGene00003541

Interactioni

Protein-protein interaction databases

BioGridi53089, 1 interactor
DIPiDIP-26108N
IntActiQ22398, 1 interactor
STRINGi6239.T11F9.6

Structurei

3D structure databases

ProteinModelPortaliQ22398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 270EGF-likeAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
ENOG410ZPX7 LUCA
GeneTreeiENSGT00760000119227
InParanoidiQ22398
OMAiINKYYEC
OrthoDBiEOG091G0FPC
PhylomeDBiQ22398

Family and domain databases

Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR024079 MetalloPept_cat_dom_sf
IPR017050 Metallopeptidase_nem
IPR001506 Peptidase_M12A
IPR006026 Peptidase_Metallo
PfamiView protein in Pfam
PF01400 Astacin, 1 hit
PIRSFiPIRSF036365 Astacin_nematoda, 1 hit
PRINTSiPR00480 ASTACIN
SMARTiView protein in SMART
SM00235 ZnMc, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFFILLSI LQECYGKDIV ARIGGRNVAE KIGGARHRRQ VLIRGSDEER
60 70 80 90 100
RHKWFNNTVH YYFYEENFDF TVKESILRAM ELISNHTCIK FSTEPSEKSI
110 120 130 140 150
RMESDSTTIA CYAEIGQVRE NQLFSFNSDC YSAGVAVHEL IHSLGFIHAH
160 170 180 190 200
QRSDRDQYLE FKKNLDELNQ TYQEQYKIWE YQEILVPYDV GSVMQYPNEE
210 220 230 240 250
DEEYYPVRKY RTMANTMGSA IVAFYDYLMI NKYYECSCAN NLSCKNHGYP
260 270 280 290 300
NPSNCSQCNC PYGFGGADCS QRAEPGATFQ ATETWQNVTI SLDAGYRYLE
310 320 330 340 350
NNQKLPQVDF IYQFLWIMAP ANKTTQIRVE KFVEGKCLPG CIRGGVEIKT
360
NEDPRLTSPR LCCEETS
Length:367
Mass (Da):42,514
Last modified:March 23, 2010 - v3
Checksum:i56D8AAE1B5F497F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74042 Genomic DNA Translation: CAA98530.2
AJ561212 mRNA Translation: CAE47484.1
PIRiT24838
RefSeqiNP_505908.2, NM_073507.3
UniGeneiCel.2323

Genome annotation databases

EnsemblMetazoaiT11F9.6; T11F9.6; WBGene00003541
GeneIDi188423
KEGGicel:CELE_T11F9.6
UCSCiT11F9.6 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNAS22_CAEEL
AccessioniPrimary (citable) accession number: Q22398
Secondary accession number(s): Q70MS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health