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Protein
Submitted name:

Protein AST-1

Gene

ast-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. dopaminergic neuron differentiation Source: WormBase
  2. positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  3. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

SignaLinkiQ22355.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein AST-1Imported
Gene namesi
Name:ast-1Imported
ORF Names:CELE_T08H4.3Imported, T08H4.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiT08H4.3; CE19576; WBGene00020368; ast-1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ22355.
PRIDEiQ22355.

Interactioni

Protein-protein interaction databases

STRINGi6239.T08H4.3.

Structurei

3D structure databases

ProteinModelPortaliQ22355.
SMRiQ22355. Positions 210-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.UniRule annotation
Contains 1 ETS DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG242679.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000022152.
InParanoidiQ22355.
OMAiFNISMNA.
OrthoDBiEOG73V6K8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22355-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVVSSATLP PTVASADLAI VGGRSSDEDV IKYSAIQTIK QEQQQQQQQQ
60 70 80 90 100
SNTALPSYNF PFFNGMQNDF PPNRMLYNDN TMQKSENDHF TGMNLSTSAS
110 120 130 140 150
SSGNSTSSKD QSRRQFYTES SNSSGNGAAA TSGSNGSSSS TESKSDVFNI
160 170 180 190 200
SMNAFAATPG SKSEDHNIPS FNMLSSYYTG ALKLSNSTSF ANPDPYQILG
210 220 230 240 250
PTSKNLAHSG SGQTQLWQFL LELLSDKRYS EVITWEGTQG EFKLVDPDEV
260 270 280 290 300
ARKWGERKSK PNMNYDKMSR ALRYYYDKNI MAKVHGKRYA YKFDFQGIAQ
310 320 330 340 350
ALQPPTASHP QDYFNSHAMG RIAPDFSSWT SANYRSLNIA GFNNGSTIFN
360 370
PSVNYSAFGA TGTSNNLSAA RAFPLYR
Length:377
Mass (Da):41,466
Last modified:January 1, 1999 - v2
Checksum:iD78A6BFA2472D409
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081683 Genomic DNA. Translation: CCD73307.1.
PIRiT34343.
RefSeqiNP_001022326.1. NM_001027155.4.
UniGeneiCel.7048.

Genome annotation databases

EnsemblMetazoaiT08H4.3; T08H4.3; WBGene00020368.
GeneIDi173749.
KEGGicel:CELE_T08H4.3.
UCSCiT08H4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081683 Genomic DNA. Translation: CCD73307.1.
PIRiT34343.
RefSeqiNP_001022326.1. NM_001027155.4.
UniGeneiCel.7048.

3D structure databases

ProteinModelPortaliQ22355.
SMRiQ22355. Positions 210-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T08H4.3.

Proteomic databases

PaxDbiQ22355.
PRIDEiQ22355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT08H4.3; T08H4.3; WBGene00020368.
GeneIDi173749.
KEGGicel:CELE_T08H4.3.
UCSCiT08H4.3. c. elegans.

Organism-specific databases

CTDi173749.
WormBaseiT08H4.3; CE19576; WBGene00020368; ast-1.

Phylogenomic databases

eggNOGiNOG242679.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000022152.
InParanoidiQ22355.
OMAiFNISMNA.
OrthoDBiEOG73V6K8.

Enzyme and pathway databases

SignaLinkiQ22355.

Miscellaneous databases

NextBioi880923.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22355_CAEEL
AccessioniPrimary (citable) accession number: Q22355
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1999
Last modified: February 4, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.