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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial

Gene

acdh-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathway: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Substrate; via carbonyl oxygenBy similarity
Active sitei391 – 3911Proton acceptorBy similarity
Binding sitei392 – 3921Substrate; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 15710FADBy similarity
Nucleotide bindingi181 – 1833FADBy similarity
Nucleotide bindingi306 – 3072FADBy similarity
Nucleotide bindingi364 – 3685FADBy similarity
Nucleotide bindingi393 – 3953FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_337595. mitochondrial fatty acid beta-oxidation of unsaturated fatty acids.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:acdh-10
ORF Names:T08G2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT08G2.3; CE07473; WBGene00020366; acdh-10.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1515MitochondrionBy similarityAdd
BLAST
Chaini16 – 417402Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrialPRO_0000000507Add
BLAST

Proteomic databases

PaxDbiQ22347.

Expressioni

Tissue specificityi

Expressed in the epidermis and intestine.1 Publication

Inductioni

By serotonin.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-25385N.
MINTiMINT-1088754.
STRINGi6239.T08G2.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ22347.
SMRiQ22347. Positions 28-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2714Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
InParanoidiQ22347.
OMAiIAMGTFD.
OrthoDBiEOG74FF0S.
PhylomeDBiQ22347.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRIATSSL GLSRSATGVI ATQSRQISFD LSETQKEIQD AALKFSKDVL
60 70 80 90 100
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE
110 120 130 140 150
ALSYGCTGIQ LGIMGPSLAI APVYISGNEE QKKKYLGALA AEPIIASYCV
160 170 180 190 200
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDPN
210 220 230 240 250
PKTPAGKAFT AFIVDGDTPG ITRGKKEKNM GQRCSDTRVI TFEDVRVPAE
260 270 280 290 300
NVLGAPGAGF KVAMEAFDMT RPGVAAGALG LSWRCLDESA KYALERKAFG
310 320 330 340 350
TVIANHQAVQ FMLADMAVNL ELARLITYKS ANDVDNKVRS SYNASIAKCF
360 370 380 390 400
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV
410
ISRMLLGHFA QNGTSRI
Length:417
Mass (Da):44,818
Last modified:November 1, 1996 - v1
Checksum:i98CE260E72C521BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080161 Genomic DNA. Translation: CCD61702.1.
PIRiT16838.

Genome annotation databases

EnsemblMetazoaiT08G2.3.1; T08G2.3.1; WBGene00020366.
T08G2.3.2; T08G2.3.2; WBGene00020366.
UCSCiT08G2.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080161 Genomic DNA. Translation: CCD61702.1.
PIRiT16838.

3D structure databases

ProteinModelPortaliQ22347.
SMRiQ22347. Positions 28-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-25385N.
MINTiMINT-1088754.
STRINGi6239.T08G2.3.1.

Proteomic databases

PaxDbiQ22347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT08G2.3.1; T08G2.3.1; WBGene00020366.
T08G2.3.2; T08G2.3.2; WBGene00020366.
UCSCiT08G2.3.1. c. elegans.

Organism-specific databases

WormBaseiT08G2.3; CE07473; WBGene00020366; acdh-10.

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
InParanoidiQ22347.
OMAiIAMGTFD.
OrthoDBiEOG74FF0S.
PhylomeDBiQ22347.

Enzyme and pathway databases

UniPathwayiUPA00660.
ReactomeiREACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_337595. mitochondrial fatty acid beta-oxidation of unsaturated fatty acids.

Miscellaneous databases

NextBioi915218.
PROiQ22347.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms."
    Srinivasan S., Sadegh L., Elle I.C., Christensen A.G., Faergeman N.J., Ashrafi K.
    Cell Metab. 7:533-544(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiACADM_CAEEL
AccessioniPrimary (citable) accession number: Q22347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.