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Protein

Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial

Gene

acdh-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FADBy similarity

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157Substrate; via carbonyl oxygenBy similarity1
Active sitei391Proton acceptorBy similarity1
Binding sitei392Substrate; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi148 – 157FADBy similarity10
Nucleotide bindingi181 – 183FADBy similarity3
Nucleotide bindingi306 – 307FADBy similarity2
Nucleotide bindingi364 – 368FADBy similarity5
Nucleotide bindingi393 – 395FADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-CEL-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
R-CEL-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-CEL-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
UniPathwayiUPA00660

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:acdh-10
ORF Names:T08G2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT08G2.3 ; CE07473 ; WBGene00020366 ; acdh-10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 15MitochondrionBy similarityAdd BLAST15
ChainiPRO_000000050716 – 417Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrialAdd BLAST402

Proteomic databases

EPDiQ22347
PaxDbiQ22347
PeptideAtlasiQ22347
PRIDEiQ22347

Expressioni

Tissue specificityi

Expressed in the epidermis and intestine.1 Publication

Inductioni

By serotonin.1 Publication

Gene expression databases

BgeeiWBGene00020366

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

DIPiDIP-25385N
STRINGi6239.T08G2.3.1

Structurei

3D structure databases

ProteinModelPortaliQ22347
SMRiQ22347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 271Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0140 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
InParanoidiQ22347
KOiK00249
OMAiGYRGMKE
OrthoDBiEOG091G04BS
PhylomeDBiQ22347

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRIATSSL GLSRSATGVI ATQSRQISFD LSETQKEIQD AALKFSKDVL
60 70 80 90 100
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE
110 120 130 140 150
ALSYGCTGIQ LGIMGPSLAI APVYISGNEE QKKKYLGALA AEPIIASYCV
160 170 180 190 200
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDPN
210 220 230 240 250
PKTPAGKAFT AFIVDGDTPG ITRGKKEKNM GQRCSDTRVI TFEDVRVPAE
260 270 280 290 300
NVLGAPGAGF KVAMEAFDMT RPGVAAGALG LSWRCLDESA KYALERKAFG
310 320 330 340 350
TVIANHQAVQ FMLADMAVNL ELARLITYKS ANDVDNKVRS SYNASIAKCF
360 370 380 390 400
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV
410
ISRMLLGHFA QNGTSRI
Length:417
Mass (Da):44,818
Last modified:November 1, 1996 - v1
Checksum:i98CE260E72C521BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080161 Genomic DNA Translation: CCD61702.1
PIRiT16838
RefSeqiNP_001294824.1, NM_001307895.1

Genome annotation databases

EnsemblMetazoaiT08G2.3.1; T08G2.3.1; WBGene00020366
T08G2.3.2; T08G2.3.2; WBGene00020366
GeneIDi24104866
KEGGicel:CELE_T08G2.3
UCSCiT08G2.3.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiACADM_CAEEL
AccessioniPrimary (citable) accession number: Q22347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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