Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q22347

- ACADM_CAEEL

UniProt

Q22347 - ACADM_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial

Gene

acdh-10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Substrate; via carbonyl oxygenBy similarity
Active sitei391 – 3911Proton acceptorBy similarity
Binding sitei392 – 3921Substrate; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi148 – 15710FADBy similarity
Nucleotide bindingi181 – 1833FADBy similarity
Nucleotide bindingi306 – 3072FADBy similarity
Nucleotide bindingi364 – 3685FADBy similarity
Nucleotide bindingi393 – 3953FADBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_183198. PPARA activates gene expression.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:acdh-10
ORF Names:T08G2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiT08G2.3; CE07473; WBGene00020366; acdh-10.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1515MitochondrionBy similarityAdd
BLAST
Chaini16 – 417402Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrialPRO_0000000507Add
BLAST

Proteomic databases

PaxDbiQ22347.

Expressioni

Tissue specificityi

Expressed in the epidermis and intestine.1 Publication

Inductioni

By serotonin.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi46634. 2 interactions.
DIPiDIP-25385N.
MINTiMINT-1088754.
STRINGi6239.T08G2.3.1.

Structurei

3D structure databases

ProteinModelPortaliQ22347.
SMRiQ22347. Positions 28-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni268 – 2714Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
InParanoidiQ22347.
OMAiSAWEVDQ.
OrthoDBiEOG74FF0S.
PhylomeDBiQ22347.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q22347 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRIATSSL GLSRSATGVI ATQSRQISFD LSETQKEIQD AALKFSKDVL
60 70 80 90 100
VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE
110 120 130 140 150
ALSYGCTGIQ LGIMGPSLAI APVYISGNEE QKKKYLGALA AEPIIASYCV
160 170 180 190 200
TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDPN
210 220 230 240 250
PKTPAGKAFT AFIVDGDTPG ITRGKKEKNM GQRCSDTRVI TFEDVRVPAE
260 270 280 290 300
NVLGAPGAGF KVAMEAFDMT RPGVAAGALG LSWRCLDESA KYALERKAFG
310 320 330 340 350
TVIANHQAVQ FMLADMAVNL ELARLITYKS ANDVDNKVRS SYNASIAKCF
360 370 380 390 400
AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV
410
ISRMLLGHFA QNGTSRI
Length:417
Mass (Da):44,818
Last modified:November 1, 1996 - v1
Checksum:i98CE260E72C521BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080161 Genomic DNA. Translation: CCD61702.1.
PIRiT16838.

Genome annotation databases

EnsemblMetazoaiT08G2.3.1; T08G2.3.1; WBGene00020366.
T08G2.3.2; T08G2.3.2; WBGene00020366.
UCSCiT08G2.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080161 Genomic DNA. Translation: CCD61702.1 .
PIRi T16838.

3D structure databases

ProteinModelPortali Q22347.
SMRi Q22347. Positions 28-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46634. 2 interactions.
DIPi DIP-25385N.
MINTi MINT-1088754.
STRINGi 6239.T08G2.3.1.

Proteomic databases

PaxDbi Q22347.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T08G2.3.1 ; T08G2.3.1 ; WBGene00020366 .
T08G2.3.2 ; T08G2.3.2 ; WBGene00020366 .
UCSCi T08G2.3.1. c. elegans.

Organism-specific databases

WormBasei T08G2.3 ; CE07473 ; WBGene00020366 ; acdh-10.

Phylogenomic databases

eggNOGi COG1960.
GeneTreei ENSGT00760000119007.
HOGENOMi HOG000131659.
InParanoidi Q22347.
OMAi SAWEVDQ.
OrthoDBi EOG74FF0S.
PhylomeDBi Q22347.

Enzyme and pathway databases

UniPathwayi UPA00660 .
Reactomei REACT_183198. PPARA activates gene expression.

Miscellaneous databases

NextBioi 915218.

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms."
    Srinivasan S., Sadegh L., Elle I.C., Christensen A.G., Faergeman N.J., Ashrafi K.
    Cell Metab. 7:533-544(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiACADM_CAEEL
AccessioniPrimary (citable) accession number: Q22347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3