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Q22347

- ACADM_CAEEL

UniProt

Q22347 - ACADM_CAEEL

Protein

Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial

Gene

acdh-10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This enzyme is specific for acyl chain lengths of 4 to 16.By similarity

    Catalytic activityi

    A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei157 – 1571Substrate; via carbonyl oxygenBy similarity
    Active sitei391 – 3911Proton acceptorBy similarity
    Binding sitei392 – 3921Substrate; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi148 – 15710FADBy similarity
    Nucleotide bindingi181 – 1833FADBy similarity
    Nucleotide bindingi306 – 3072FADBy similarity
    Nucleotide bindingi364 – 3685FADBy similarity
    Nucleotide bindingi393 – 3953FADBy similarity

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    ReactomeiREACT_183198. PPARA activates gene expression.
    UniPathwayiUPA00660.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial (EC:1.3.8.7)
    Short name:
    MCAD
    Gene namesi
    Name:acdh-10
    ORF Names:T08G2.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiT08G2.3; CE07473; WBGene00020366; acdh-10.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1515MitochondrionBy similarityAdd
    BLAST
    Chaini16 – 417402Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrialPRO_0000000507Add
    BLAST

    Proteomic databases

    PaxDbiQ22347.

    Expressioni

    Tissue specificityi

    Expressed in the epidermis and intestine.1 Publication

    Inductioni

    By serotonin.1 Publication

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi46634. 2 interactions.
    DIPiDIP-25385N.
    MINTiMINT-1088754.
    STRINGi6239.T08G2.3.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22347.
    SMRiQ22347. Positions 28-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni268 – 2714Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the acyl-CoA dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1960.
    GeneTreeiENSGT00750000117417.
    HOGENOMiHOG000131659.
    InParanoidiQ22347.
    OMAiSAWEVDQ.
    OrthoDBiEOG74FF0S.
    PhylomeDBiQ22347.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q22347-1 [UniParc]FASTAAdd to Basket

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    MLSRIATSSL GLSRSATGVI ATQSRQISFD LSETQKEIQD AALKFSKDVL    50
    VPNAAKFDES GEFPWEIVRQ AHSLGLMNPQ IPEKYGGPGM TTLETALIVE 100
    ALSYGCTGIQ LGIMGPSLAI APVYISGNEE QKKKYLGALA AEPIIASYCV 150
    TEPGAGSDVN GVKTKCEKKG DEYIINGSKA WITGGGHAKW FFVLARSDPN 200
    PKTPAGKAFT AFIVDGDTPG ITRGKKEKNM GQRCSDTRVI TFEDVRVPAE 250
    NVLGAPGAGF KVAMEAFDMT RPGVAAGALG LSWRCLDESA KYALERKAFG 300
    TVIANHQAVQ FMLADMAVNL ELARLITYKS ANDVDNKVRS SYNASIAKCF 350
    AADTANQAAT NAVQIFGGNG FNSEYPVEKL MRDAKIYQIY EGTSQIQRIV 400
    ISRMLLGHFA QNGTSRI 417
    Length:417
    Mass (Da):44,818
    Last modified:November 1, 1996 - v1
    Checksum:i98CE260E72C521BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080161 Genomic DNA. Translation: CCD61702.1.
    PIRiT16838.

    Genome annotation databases

    EnsemblMetazoaiT08G2.3.1; T08G2.3.1; WBGene00020366.
    T08G2.3.2; T08G2.3.2; WBGene00020366.
    UCSCiT08G2.3.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080161 Genomic DNA. Translation: CCD61702.1 .
    PIRi T16838.

    3D structure databases

    ProteinModelPortali Q22347.
    SMRi Q22347. Positions 28-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 46634. 2 interactions.
    DIPi DIP-25385N.
    MINTi MINT-1088754.
    STRINGi 6239.T08G2.3.1.

    Proteomic databases

    PaxDbi Q22347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T08G2.3.1 ; T08G2.3.1 ; WBGene00020366 .
    T08G2.3.2 ; T08G2.3.2 ; WBGene00020366 .
    UCSCi T08G2.3.1. c. elegans.

    Organism-specific databases

    WormBasei T08G2.3 ; CE07473 ; WBGene00020366 ; acdh-10.

    Phylogenomic databases

    eggNOGi COG1960.
    GeneTreei ENSGT00750000117417.
    HOGENOMi HOG000131659.
    InParanoidi Q22347.
    OMAi SAWEVDQ.
    OrthoDBi EOG74FF0S.
    PhylomeDBi Q22347.

    Enzyme and pathway databases

    UniPathwayi UPA00660 .
    Reactomei REACT_183198. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 915218.

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR006089. Acyl-CoA_DH_CS.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF02771. Acyl-CoA_dh_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 1 hit.
    SSF56645. SSF56645. 1 hit.
    PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
    PS00073. ACYL_COA_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms."
      Srinivasan S., Sadegh L., Elle I.C., Christensen A.G., Faergeman N.J., Ashrafi K.
      Cell Metab. 7:533-544(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiACADM_CAEEL
    AccessioniPrimary (citable) accession number: Q22347
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3