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Protein

Aminopeptidase

Gene

anp-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminopeptidaseUniRule annotationImported, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiM01.015.

Names & Taxonomyi

Protein namesi
Recommended name:
AminopeptidaseUniRule annotation (EC:3.4.11.-UniRule annotation)
Gene namesi
Name:anp-1Imported
ORF Names:CELE_T07F10.1Imported, T07F10.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT07F10.1a; CE21162; WBGene00011587; anp-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 51HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ22317.
PaxDbiQ22317.

Expressioni

Gene expression databases

BgeeiWBGene00011587.
ExpressionAtlasiQ22317. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.T07F10.1a.

Structurei

3D structure databases

ProteinModelPortaliQ22317.
SMRiQ22317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini307 – 552Peptidase_M1InterPro annotationAdd BLAST246
Domaini632 – 954ERAP1_CInterPro annotationAdd BLAST323

Sequence similaritiesi

Belongs to the peptidase M1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1046. Eukaryota.
COG0308. LUCA.
GeneTreeiENSGT00760000119082.
HOGENOMiHOG000018912.
InParanoidiQ22317.
KOiK11140.
OMAiAFITWHI.
OrthoDBiEOG091G01GH.
PhylomeDBiQ22317.

Family and domain databases

CDDicd09601. M1_APN_2. 1 hit.
InterProiView protein in InterPro
IPR024571. ERAP1-like_C_dom.
IPR034016. M1_APN-typ.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiView protein in Pfam
PF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
PRINTSiPR00756. ALADIPTASE.

Sequencei

Sequence statusi: Complete.

Q22317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAYTYGSF PQMGHPPPKE TKKGCQVKSF VLPVFCTLLG VLITAFITWH
60 70 80 90 100
ITKSQYSRND PHDEIESENV PAAKPEDNIS ASELRLPTSV SPISYQLTVK
110 120 130 140 150
TYLPGYGYTA DKNNLTFEGQ VLIELNITKS IKKVSLNSKD LNYTEEFIKK
160 170 180 190 200
SSILVNGKSI AFTLDDKQST HEKIFFNLDE TVEPTTSATL KVAFGAPLRT
210 220 230 240 250
DMSGLYQTTY TNSKGESKMA AVTQMEPVYA RRMVPCFDEP AYKATWTVTV
260 270 280 290 300
IHPNKTVAVS NGIEDKVEDG QPGFIISTFK PTPRMSSYLL AIFISEFEYN
310 320 330 340 350
EATTKSGVRF RVWSRPEEKN STMYAVEAGV KCLEYYEKYY NISFPLPKQD
360 370 380 390 400
MVALPDFSAG AMENWGLITY RESALLYDPR IYSGSQKRRV AVVIAHELAH
410 420 430 440 450
QWFGNLVTLK WWNDLWLNEG FATLVEYLGT DEISDGNMRM REWFTMDALW
460 470 480 490 500
SALAADSVAS THPLTFKIDK AMEVLDSFDS VTYDKGGAVL AMVRKTIGEE
510 520 530 540 550
NFNTGINHYL TRHQFDNADA GNLLTALGEK IPDSVMGPKG VKLNISEFMD
560 570 580 590 600
PWTKQLGYPL LNASRINNTH IIVEQSRFKL LATGKEEEKY SNPVWGFKWD
610 620 630 640 650
VPVWYQVVGS SELEMKWMKR NEPLIIKSDK NVIINAESNG FYRAGYSSGL
660 670 680 690 700
WKEISEMLKE NHEQFSPQTR VRLIDDSFAL ARAGLLSYSI PLNLITYLKN
710 720 730 740 750
EKEYLPWSGA IAKIRELIDM YGSNPEKDIV NKFMIALAEN APARRSIDFV
760 770 780 790 800
SKNYLDEKKF YEVGAAQQII LNSCGFGDSV CQADMVKMFT EEVLAKCDAT
810 820 830 840 850
RILSECSQIP APFRAESYCE AVRNGNSDTF EKVFHWYKTE RNQVEKLNLM
860 870 880 890 900
TALTCSKDIL TLKKLLLDAM KPEGSSFRLQ DCAALFAKIS SNDATTDAML
910 920 930 940 950
NFLIDRWEDM QKRLATDHSG FSRVLSSIVN TLKTRGGLDQ LRKFRKKAPK
960 970 980
ASEFGLDKME ESAEVTVTWR ETNLKFVTKI IEEISKSL
Length:988
Mass (Da):111,825
Last modified:January 1, 1999 - v2
Checksum:iD2EDD47BA793F956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB01242.1.
PIRiT24668.
RefSeqiNP_001041160.1. NM_001047695.3.
UniGeneiCel.33019.

Genome annotation databases

EnsemblMetazoaiT07F10.1a; T07F10.1a; WBGene00011587.
GeneIDi179763.
KEGGicel:CELE_T07F10.1.
UCSCiT07F10.1a. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ22317_CAEEL
AccessioniPrimary (citable) accession number: Q22317
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1999
Last modified: November 22, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported