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Q22295

- UGT50_CAEEL

UniProt

Q22295 - UGT50_CAEEL

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Protein

Putative UDP-glucuronosyltransferase ugt-50

Gene

ugt-50

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative UDP-glucuronosyltransferase ugt-50 (EC:2.4.1.17)
Short name:
UDPGT 50
Gene namesi
Name:ugt-50
Synonyms:ugt16
ORF Names:T07C5.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome X

Organism-specific databases

WormBaseiT07C5.1b; CE18217; WBGene00011564; ugt-50.
T07C5.1c; CE31603; WBGene00011564; ugt-50.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei490 – 50819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 523498Putative UDP-glucuronosyltransferase ugt-50PRO_0000036055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)1 Publication
Glycosylationi248 – 2481N-linked (GlcNAc...)1 Publication
Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ22295.
PRIDEiQ22295.

Interactioni

Protein-protein interaction databases

STRINGi6239.T07C5.1c.

Structurei

3D structure databases

ProteinModelPortaliQ22295.
SMRiQ22295. Positions 286-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00770000120743.
HOGENOMiHOG000018870.
InParanoidiQ22295.
KOiK00699.
OMAiDGAKHAK.
PhylomeDBiQ22295.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform c (identifier: Q22295-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHYSQMRWMF FCLTALLHGS FIVNAAKILV YCPSISKSHV LLCSKYADLL
60 70 80 90 100
HNAGHDTVLF IPSYSKLLDN YDGAKHAKVW RLHNVTEAYD TKLGTLANVM
110 120 130 140 150
ENSHIGFIDR LTFDADFWID MCADLLGKLP EMQHIIDYKF DLVIYNEIDP
160 170 180 190 200
CTPAIVRLFN IPKTVLLSSE AIMDKVAWNL GLPTLPSYVP SVEENPNHDR
210 220 230 240 250
MSFFERMSNV YKFFQSIVVH YLQDIHVLNL FRKEVSSDFP SIAEIIRNVS
260 270 280 290 300
LVLVNTDEIF DLPRSYSSKF VYVGMLEAGK DENVTLPKKQ DDYFKKGKSG
310 320 330 340 350
SVFVSFGTVT PFRSLPERIQ LSILNAIQKL PDYHFVVKTT ADDESSAQFF
360 370 380 390 400
STVQNVDLVD WVPQKAVLRH ANLKLFVSHG GMNSVLETMY YGVPMVIMPV
410 420 430 440 450
FTDQFRNGRN VERRGAGKMV LRETVVKETF FDAIHSVLEE KSYSSSVKRI
460 470 480 490 500
SHLMKNKPFT SEERVTKWID FVLKYETSEH FDLESNNLSI IEHNHLDLFF
510 520
YLCIISLLNF VVYRKIFKRK SQS

Note: No experimental confirmation available.

Length:523
Mass (Da):60,286
Last modified:November 28, 2006 - v2
Checksum:i6D00E382BFF26C4D
GO
Isoform b (identifier: Q22295-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-190: LPTLPSYVP → KPMTTFAES
     191-523: Missing.

Note: No experimental confirmation available.

Show »
Length:190
Mass (Da):21,650
Checksum:i1032764C783A68BB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei182 – 1909LPTLPSYVP → KPMTTFAES in isoform b. CuratedVSP_021638
Alternative sequencei191 – 523333Missing in isoform b. CuratedVSP_021639Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50006 Genomic DNA. Translation: CAA90301.1.
Z50006 Genomic DNA. Translation: CAD44148.1.
PIRiT24647.
T24652.
RefSeqiNP_510118.1. NM_077717.3. [Q22295-2]
NP_741913.1. NM_171786.5. [Q22295-1]
UniGeneiCel.406.

Genome annotation databases

EnsemblMetazoaiT07C5.1c; T07C5.1c; WBGene00011564. [Q22295-1]
GeneIDi181413.
KEGGicel:CELE_T07C5.1.
UCSCiT07C5.1b. c. elegans. [Q22295-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50006 Genomic DNA. Translation: CAA90301.1 .
Z50006 Genomic DNA. Translation: CAD44148.1 .
PIRi T24647.
T24652.
RefSeqi NP_510118.1. NM_077717.3. [Q22295-2 ]
NP_741913.1. NM_171786.5. [Q22295-1 ]
UniGenei Cel.406.

3D structure databases

ProteinModelPortali Q22295.
SMRi Q22295. Positions 286-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T07C5.1c.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi Q22295.
PRIDEi Q22295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T07C5.1c ; T07C5.1c ; WBGene00011564 . [Q22295-1 ]
GeneIDi 181413.
KEGGi cel:CELE_T07C5.1.
UCSCi T07C5.1b. c. elegans. [Q22295-1 ]

Organism-specific databases

CTDi 181413.
WormBasei T07C5.1b ; CE18217 ; WBGene00011564 ; ugt-50.
T07C5.1c ; CE31603 ; WBGene00011564 ; ugt-50.

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00770000120743.
HOGENOMi HOG000018870.
InParanoidi Q22295.
KOi K00699.
OMAi DGAKHAK.
PhylomeDBi Q22295.

Miscellaneous databases

NextBioi 913828.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-248 AND ASN-283, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiUGT50_CAEEL
AccessioniPrimary (citable) accession number: Q22295
Secondary accession number(s): O62371, Q8MPX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2006
Last modified: November 26, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3