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Q22295

- UGT50_CAEEL

UniProt

Q22295 - UGT50_CAEEL

Protein

Putative UDP-glucuronosyltransferase ugt-50

Gene

ugt-50

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative UDP-glucuronosyltransferase ugt-50 (EC:2.4.1.17)
    Short name:
    UDPGT 50
    Gene namesi
    Name:ugt-50
    Synonyms:ugt16
    ORF Names:T07C5.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome X

    Organism-specific databases

    WormBaseiT07C5.1b; CE18217; WBGene00011564; ugt-50.
    T07C5.1c; CE31603; WBGene00011564; ugt-50.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 523498Putative UDP-glucuronosyltransferase ugt-50PRO_0000036055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi84 – 841N-linked (GlcNAc...)1 Publication
    Glycosylationi248 – 2481N-linked (GlcNAc...)1 Publication
    Glycosylationi283 – 2831N-linked (GlcNAc...)1 Publication
    Glycosylationi487 – 4871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ22295.
    PRIDEiQ22295.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T07C5.1c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22295.
    SMRiQ22295. Positions 286-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei490 – 50819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00740000115714.
    HOGENOMiHOG000018870.
    InParanoidiQ22295.
    KOiK00699.
    OMAiDGAKHAK.
    PhylomeDBiQ22295.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform c (identifier: Q22295-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHYSQMRWMF FCLTALLHGS FIVNAAKILV YCPSISKSHV LLCSKYADLL    50
    HNAGHDTVLF IPSYSKLLDN YDGAKHAKVW RLHNVTEAYD TKLGTLANVM 100
    ENSHIGFIDR LTFDADFWID MCADLLGKLP EMQHIIDYKF DLVIYNEIDP 150
    CTPAIVRLFN IPKTVLLSSE AIMDKVAWNL GLPTLPSYVP SVEENPNHDR 200
    MSFFERMSNV YKFFQSIVVH YLQDIHVLNL FRKEVSSDFP SIAEIIRNVS 250
    LVLVNTDEIF DLPRSYSSKF VYVGMLEAGK DENVTLPKKQ DDYFKKGKSG 300
    SVFVSFGTVT PFRSLPERIQ LSILNAIQKL PDYHFVVKTT ADDESSAQFF 350
    STVQNVDLVD WVPQKAVLRH ANLKLFVSHG GMNSVLETMY YGVPMVIMPV 400
    FTDQFRNGRN VERRGAGKMV LRETVVKETF FDAIHSVLEE KSYSSSVKRI 450
    SHLMKNKPFT SEERVTKWID FVLKYETSEH FDLESNNLSI IEHNHLDLFF 500
    YLCIISLLNF VVYRKIFKRK SQS 523

    Note: No experimental confirmation available.

    Length:523
    Mass (Da):60,286
    Last modified:November 28, 2006 - v2
    Checksum:i6D00E382BFF26C4D
    GO
    Isoform b (identifier: Q22295-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         182-190: LPTLPSYVP → KPMTTFAES
         191-523: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:190
    Mass (Da):21,650
    Checksum:i1032764C783A68BB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei182 – 1909LPTLPSYVP → KPMTTFAES in isoform b. CuratedVSP_021638
    Alternative sequencei191 – 523333Missing in isoform b. CuratedVSP_021639Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50006 Genomic DNA. Translation: CAA90301.1.
    Z50006 Genomic DNA. Translation: CAD44148.1.
    PIRiT24647.
    T24652.
    RefSeqiNP_510118.1. NM_077717.3. [Q22295-2]
    NP_741913.1. NM_171786.5. [Q22295-1]
    UniGeneiCel.406.

    Genome annotation databases

    EnsemblMetazoaiT07C5.1c; T07C5.1c; WBGene00011564. [Q22295-1]
    GeneIDi181413.
    KEGGicel:CELE_T07C5.1.
    UCSCiT07C5.1b. c. elegans. [Q22295-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50006 Genomic DNA. Translation: CAA90301.1 .
    Z50006 Genomic DNA. Translation: CAD44148.1 .
    PIRi T24647.
    T24652.
    RefSeqi NP_510118.1. NM_077717.3. [Q22295-2 ]
    NP_741913.1. NM_171786.5. [Q22295-1 ]
    UniGenei Cel.406.

    3D structure databases

    ProteinModelPortali Q22295.
    SMRi Q22295. Positions 286-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T07C5.1c.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q22295.
    PRIDEi Q22295.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T07C5.1c ; T07C5.1c ; WBGene00011564 . [Q22295-1 ]
    GeneIDi 181413.
    KEGGi cel:CELE_T07C5.1.
    UCSCi T07C5.1b. c. elegans. [Q22295-1 ]

    Organism-specific databases

    CTDi 181413.
    WormBasei T07C5.1b ; CE18217 ; WBGene00011564 ; ugt-50.
    T07C5.1c ; CE31603 ; WBGene00011564 ; ugt-50.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00740000115714.
    HOGENOMi HOG000018870.
    InParanoidi Q22295.
    KOi K00699.
    OMAi DGAKHAK.
    PhylomeDBi Q22295.

    Miscellaneous databases

    NextBioi 913828.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
      Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
      Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-248 AND ASN-283, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUGT50_CAEEL
    AccessioniPrimary (citable) accession number: Q22295
    Secondary accession number(s): O62371, Q8MPX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3