Q22267 (PLC2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
Short name=1-AGP acyltransferase
Short name=1-AGPAT
EC=2.3.1.51

Alternative name(s):
Lysophosphatidic acid acyltransferase
Short name=LPAAT

Gene names

Name:	acl-2
ORF Names:	T06E8.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2		PRO_0000208203
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Motif	98 – 103	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q22267 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 577D25A65F318C64	FASTA	282	32,691
	10 20 30 40 50 60 MENFWSIVVF FLLSILFILY NISTVCHYYM RISFYYFTIL LHGMEVCVTM IPSWLNGKGA 70 80 90 100 110 120 DYVFHSFFYW CKWTGVHTTV YGYEKTQVEG PAVVICNHQS SLDILSMASI WPKNCVVMMK 130 140 150 160 170 180 RILAYVPFFN LGAYFSNTIF IDRYNRERAM ASVDYCASEM KNRNLKLWVF PEGTRNREGG 190 200 210 220 230 240 FIPFKKGAFN IAVRAQIPII PVVFSDYRDF YSKPGRYFKN DGEVVIRVLD AIPTKGLTLD 250 260 270 280 DVSELSDMCR DVMLAAYKEV TLEAQQRNAT RRGETKDGKK SE

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73975 Genomic DNA. Translation: CAA98276.1.
PIR	T24610.
RefSeq	NP_505578.1. NM_073177.3.
UniGene	Cel.36470.
3D structure databases
ProteinModelPortal	Q22267.
ModBase	Search...
Protein-protein interaction databases
STRING	Q22267.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T06E8.1.1; T06E8.1.1; T06E8.1. T06E8.1.2; T06E8.1.2; T06E8.1.
GeneID	179398.
KEGG	cel:T06E8.1.
NMPDR	fig|6239.3.peg.19283.
UCSC	T06E8.1.1. c. elegans.
Organism-specific databases
CTD	179398.
WormBase	T06E8.1; CE06378; WBGene00011543; acl-2.
Phylogenomic databases
eggNOG	meNOG11486.
GeneTree	EMGT00050000007043.
HOGENOM	HBG736534.
InParanoid	Q22267.
OMA	VICNHQS.
PhylomeDB	Q22267.
Gene expression databases
ArrayExpress	Q22267.
Family and domain databases
InterPro	IPR002123. Acyltransferase. IPR004552. AGP_acyltrans. [Graphical view]
KO	K13509.
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00530. AGP_acyltrn. 1 hit.
ProtoNet	Search...
Other
NextBio	905224.

Entry information

Entry name

PLC2_CAEEL

Accession

Primary (citable) accession number: Q22267

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project