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Protein
Submitted name:

Proteasome Regulatory Particle, Non-ATPase-like

Gene

rpn-9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Proteasome Regulatory Particle, Non-ATPase-likeImported
Gene namesi
Name:rpn-9Imported
ORF Names:CELE_T06D8.8Imported, T06D8.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT06D8.8; CE02329; WBGene00004465; rpn-9.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleus Source: GO_Central
  • proteasome regulatory particle Source: WormBase
  • proteasome regulatory particle, lid subcomplex Source: GO_Central

Keywords - Cellular componenti

ProteasomeImported

PTM / Processingi

Proteomic databases

EPDiQ22253.
PaxDbiQ22253.
PeptideAtlasiQ22253.

Expressioni

Gene expression databases

BgeeiWBGene00004465.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rpn-8O617924EBI-326317,EBI-324407

Protein-protein interaction databases

IntActiQ22253. 4 interactors.
MINTiMINT-210985.
STRINGi6239.T06D8.8.1.

Structurei

3D structure databases

ProteinModelPortaliQ22253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini272 – 365PCIInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiKOG2908. Eukaryota.
ENOG410XPG9. LUCA.
GeneTreeiENSGT00390000001802.
HOGENOMiHOG000216633.
InParanoidiQ22253.
KOiK03039.
OMAiKFADKIN.
OrthoDBiEOG091G0977.
PhylomeDBiQ22253.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQDYLNGK LAAANGPLAD DWKNLKELWE KKLWHQLTVL TRSLVKKPQF
60 70 80 90 100
VASTDMHEFY RLFVAEWELR VNPLQLVEIC ISIAQNIATK DKQKSMEFLS
110 120 130 140 150
KIGNVINKDK IAVARLHTGE IEARLENKDK NGQIIDLKSI RTQIDSTQHE
160 170 180 190 200
VDSLVGVTEV HAPFYRVSSL YLREVGDFAG YYREALRYLG VEDANNLTTE
210 220 230 240 250
QKQVHAVLLG FAALLGENVH NFGELLAHPI LKSLEGTRER WIVDVLLAFN
260 270 280 290 300
SGDLTRFFSL EGDWGGWDDL KKQKDFLTAK IRLMAVMELA VSRPTKARSV
310 320 330 340 350
SFKEIATKCQ IPFDEVEFLV MKALSKDLIR GDINQVEQVV YVTWVQPRVL
360 370 380
DNPQIMQMAT RISAWRNDVN SMEGIVSKEA REILTQN
Length:387
Mass (Da):44,160
Last modified:November 1, 1996 - v1
Checksum:i3E4D1D15B2616A6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88971.1.
PIRiT24581.
RefSeqiNP_496405.1. NM_064004.5.
UniGeneiCel.5073.

Genome annotation databases

EnsemblMetazoaiT06D8.8.1; T06D8.8.1; WBGene00004465.
T06D8.8.2; T06D8.8.2; WBGene00004465.
GeneIDi174715.
KEGGicel:CELE_T06D8.8.
UCSCiT06D8.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88971.1.
PIRiT24581.
RefSeqiNP_496405.1. NM_064004.5.
UniGeneiCel.5073.

3D structure databases

ProteinModelPortaliQ22253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22253. 4 interactors.
MINTiMINT-210985.
STRINGi6239.T06D8.8.1.

Proteomic databases

EPDiQ22253.
PaxDbiQ22253.
PeptideAtlasiQ22253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT06D8.8.1; T06D8.8.1; WBGene00004465.
T06D8.8.2; T06D8.8.2; WBGene00004465.
GeneIDi174715.
KEGGicel:CELE_T06D8.8.
UCSCiT06D8.8.1. c. elegans.

Organism-specific databases

CTDi174715.
WormBaseiT06D8.8; CE02329; WBGene00004465; rpn-9.

Phylogenomic databases

eggNOGiKOG2908. Eukaryota.
ENOG410XPG9. LUCA.
GeneTreeiENSGT00390000001802.
HOGENOMiHOG000216633.
InParanoidiQ22253.
KOiK03039.
OMAiKFADKIN.
OrthoDBiEOG091G0977.
PhylomeDBiQ22253.

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-6798695. Neutrophil degranulation.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

BgeeiWBGene00004465.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ22253_CAEEL
AccessioniPrimary (citable) accession number: Q22253
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.