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Protein

Tyrosine-protein kinase

Gene

CELE_T06C10.3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ22243.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
ORF Names:CELE_T06C10.3Imported, T06C10.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT06C10.3; CE04901; WBGene00020289.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiQ22243.

Expressioni

Gene expression databases

BgeeiWBGene00020289.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-24800N.
IntActiQ22243. 1 interactor.
MINTiMINT-1079830.
STRINGi6239.T06C10.3.

Structurei

3D structure databases

ProteinModelPortaliQ22243.
SMRiQ22243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 251SH2InterPro annotationAdd BLAST107
Domaini263 – 520Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000114031.
InParanoidiQ22243.
OMAiFCEITRT.
OrthoDBiEOG091G0BTE.
PhylomeDBiQ22243.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNELFTRS VYMQSSVYSN NSKSSTSSSS SNSIPTQSAP AMNAASSPSK
60 70 80 90 100
EPAKQEKEDD KKEVEEKKEI EKSVEAKVEG KVKAKVESTQ NTDNSQELKA
110 120 130 140 150
PEEKPKKKKK KKSNLIVSAS VEKLSIVPEK EDFSILEKKL REFNFYHGFL
160 170 180 190 200
PREDLHTTLH NPGDFLLRVS EVVEGEHKVN REVILSLIPV STVSKDEEDR
210 220 230 240 250
KKVRNVVIKR VTNLFFCEIT RTFESISDLV TYYTKNPGGC ASGTFQLKHP
260 270 280 290 300
ILQQSWEFMH SDVTVGKVLG EGAFGKVCSG TLKLKDGTNV DVAIKMTKVS
310 320 330 340 350
AFLSKMKIKE MMNEARFIRN FNHKNVVRLY GVAHHEQPLY ILLELVKGGS
360 370 380 390 400
LQDHMKKEKG AVSIVEKIKF CSGAGRGIEY LHQNNCIHRD IAARNCLLHE
410 420 430 440 450
KEVKITDFGL SRTGPVYKMK TACKLPVKWL APETLSTLSF SFATDTYSWG
460 470 480 490 500
VTCYEVFADG VEPFFGIQNS VVKTDILANK FLQMPPTTPE SIKKYMEASI
510 520 530 540 550
FVEGSRRATM TSAIAEFEKI KSALERPPSD MLSVGAGAKK VMKLLKRNKQ

EKYSKGD
Length:557
Mass (Da):62,427
Last modified:November 1, 1996 - v1
Checksum:i90A7C108C9D6DCBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63310.1.
PIRiT16815.
RefSeqiNP_501307.1. NM_068906.1.
UniGeneiCel.12382.

Genome annotation databases

EnsemblMetazoaiT06C10.3; T06C10.3; WBGene00020289.
GeneIDi188160.
KEGGicel:CELE_T06C10.3.
UCSCiT06C10.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD63310.1.
PIRiT16815.
RefSeqiNP_501307.1. NM_068906.1.
UniGeneiCel.12382.

3D structure databases

ProteinModelPortaliQ22243.
SMRiQ22243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-24800N.
IntActiQ22243. 1 interactor.
MINTiMINT-1079830.
STRINGi6239.T06C10.3.

Proteomic databases

PaxDbiQ22243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT06C10.3; T06C10.3; WBGene00020289.
GeneIDi188160.
KEGGicel:CELE_T06C10.3.
UCSCiT06C10.3. c. elegans.

Organism-specific databases

CTDi188160.
WormBaseiT06C10.3; CE04901; WBGene00020289.

Phylogenomic databases

eggNOGiKOG0194. Eukaryota.
ENOG410Y6RP. LUCA.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000114031.
InParanoidiQ22243.
OMAiFCEITRT.
OrthoDBiEOG091G0BTE.
PhylomeDBiQ22243.

Enzyme and pathway databases

SignaLinkiQ22243.

Gene expression databases

BgeeiWBGene00020289.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ22243_CAEEL
AccessioniPrimary (citable) accession number: Q22243
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.