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Protein

Endoplasmin homolog

Gene

enpl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Molecular chaperone that functions in the processing and transport of secreted proteins.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95ATPBy similarity1
Binding sitei137ATPBy similarity1
Binding sitei150ATPBy similarity1
Binding sitei187ATP; via amide nitrogenBy similarity1
Binding sitei426ATPCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-CEL-6785807 Interleukin-4 and 13 signaling
R-CEL-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmin homologImported
Gene namesi
Name:enpl-1Imported
ORF Names:T05E11.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiT05E11.3a ; CE06362 ; WBGene00011480 ; enpl-1
T05E11.3b ; CE45764 ; WBGene00011480 ; enpl-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Adults show increased sensitivity to cisplatin, sodium arsenite and zinc. RNAi-mediated knockdown results in induction of the unfolded protein response.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000043214424 – 760Endoplasmin homologSequence analysisAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi423N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ22235
PaxDbiQ22235
PeptideAtlasiQ22235
PRIDEiQ22235

2D gel databases

World-2DPAGE0020:Q22235

Expressioni

Gene expression databases

BgeeiWBGene00011480

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-24557N
STRINGi6239.T05E11.3a.2

Structurei

3D structure databases

ProteinModelPortaliQ22235
SMRiQ22235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi757 – 760Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0020 Eukaryota
COG0326 LUCA
GeneTreeiENSGT00910000144050
HOGENOMiHOG000031988
InParanoidiQ22235
KOiK09487
OMAiSDHEIFL
OrthoDBiEOG091G0270
PhylomeDBiQ22235

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: Q22235-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFLLVGFVA LLAVSAFIPN VYAEDEIEDA PKETKEETRE EDSIKLDGLS
60 70 80 90 100
VSQIKELRSK AEKHEFQAEV NRMMKLIINS LYRNKEIFLR ELISNASDAL
110 120 130 140 150
DKIRLLSLTD PEQLRETEEM SVKIKADREN RLLHITDTGV GMTRQDLINN
160 170 180 190 200
LGTIARSGTS EFLSKLMDTA TSSDQQQDLI GQFGVGFYAA FLVADRVVVT
210 220 230 240 250
TKNNDDDQYI WESDSASFTI SKDPRGNTLK RGTQITLYLK EEAADFLEPD
260 270 280 290 300
TLKNLVHKYS QFINFDIFLW QSKTEMVEEA VEEEPATTED GAVEEEKEEK
310 320 330 340 350
KTKKVEKTTW DWEKVNNVKP IWMRKPNQVE EDEYKQFYKS ITKDSEEPLS
360 370 380 390 400
HVHFSAEGEV SFRSILYVPK KSPNDMFQNY GKVIENIKLY VRRVFITDDF
410 420 430 440 450
ADMLPKYLSF IRGIVDSDDL PLNVSRENLQ QHKLLKVIKK KLVRKVLDML
460 470 480 490 500
KKLDGAQFDD FWSEFSTNIK LGVMEDPSNR MRLAKLLRFQ SSNDADKTTT
510 520 530 540 550
LAAYVERMKE KQDAIYYMAG TSRKEVETSP FVERLIAKGY EVLFLTEAVD
560 570 580 590 600
EYCIQAMPEY ESKKFQNVAK EGVTIDDGEK AKEAHKGLEE EFKPLTDWLK
610 620 630 640 650
ETALKDLIEK AVVSQRLVKS PSALVASSYG WSGNMERIMK SQAYAKAKDP
660 670 680 690 700
TQDFYATQKK TFEINPRHPV IKELLKRVTA SEEDTTAAST AKLLFETATL
710 720 730 740 750
RSGFSLQDQV GFADRIEAVL RQSLDVSQDA QVETEQHIEE AEPEPEAAEE
760
TTIEEEHSEL
Note: No experimental confirmation available.Curated
Length:760
Mass (Da):87,112
Last modified:November 1, 1996 - v1
Checksum:i9B870D370165F2BD
GO
Isoform bImported (identifier: Q22235-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:688
Mass (Da):78,921
Checksum:i260282B4F7BACD7B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574881 – 72Missing in isoform b. CuratedAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68751 Genomic DNA Translation: CAA92973.1
Z68751 Genomic DNA Translation: CBZ01798.1
PIRiT24521
RefSeqiNP_001255536.1, NM_001268607.1 [Q22235-1]
NP_001255537.1, NM_001268608.1 [Q22235-2]
UniGeneiCel.16874

Genome annotation databases

EnsemblMetazoaiT05E11.3a.1; T05E11.3a.1; WBGene00011480 [Q22235-1]
T05E11.3a.2; T05E11.3a.2; WBGene00011480 [Q22235-1]
GeneIDi178014
KEGGicel:CELE_T05E11.3
UCSCiT05E11.3.1 c. elegans [Q22235-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiENPL1_CAEEL
AccessioniPrimary (citable) accession number: Q22235
Secondary accession number(s): E9P859
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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