ID   Q22224_CAEEL            Unreviewed;       500 AA.
AC   Q22224;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 2.
DT   27-MAR-2024, entry version 176.
DE   SubName: Full=AcetylCholine Receptor {ECO:0000313|EMBL:CAA91304.2};
GN   Name=acr-14 {ECO:0000313|EMBL:CAA91304.2,
GN   ECO:0000313|WormBase:T05C12.2};
GN   ORFNames=CELE_T05C12.2 {ECO:0000313|EMBL:CAA91304.2}, T05C12.2
GN   {ECO:0000313|WormBase:T05C12.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA91304.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAA91304.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA91304.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC       {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00034099}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC       {ECO:0000256|RuleBase:RU000687}.
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DR   EMBL; BX284602; CAA91304.2; -; Genomic_DNA.
DR   PIR; T24504; T24504.
DR   RefSeq; NP_495716.1; NM_063315.1.
DR   AlphaFoldDB; Q22224; -.
DR   SMR; Q22224; -.
DR   STRING; 6239.T05C12.2.1; -.
DR   PaxDb; 6239-T05C12-2; -.
DR   EnsemblMetazoa; T05C12.2.1; T05C12.2.1; WBGene00000053.
DR   GeneID; 191601; -.
DR   KEGG; cel:CELE_T05C12.2; -.
DR   UCSC; T05C12.2; c. elegans.
DR   AGR; WB:WBGene00000053; -.
DR   WormBase; T05C12.2; CE25099; WBGene00000053; acr-14.
DR   eggNOG; KOG3646; Eukaryota.
DR   HOGENOM; CLU_018074_0_3_1; -.
DR   InParanoid; Q22224; -.
DR   OMA; MSILAYM; -.
DR   OrthoDB; 2874957at2759; -.
DR   PhylomeDB; Q22224; -.
DR   Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00000053; Expressed in pharyngeal muscle cell (C elegans) and 1 other cell type or tissue.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0005231; F:excitatory extracellular ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR   CDD; cd18997; LGIC_ECD_nAChR; 1.
DR   CDD; cd19051; LGIC_TM_cation; 1.
DR   Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR   Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR038050; Neuro_actylchol_rec.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945:SF441; ACETYLCHOLINE RECEPTOR; 1.
DR   PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR   SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU000687};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:CAA91304.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Signal {ECO:0000256|RuleBase:RU000687};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU000687};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   CHAIN           18..500
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT                   /id="PRO_5022253113"
FT   TRANSMEM        259..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        290..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        320..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   TRANSMEM        475..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU000687"
FT   DOMAIN          21..258
FT                   /note="Neurotransmitter-gated ion-channel ligand-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02931"
FT   DOMAIN          265..491
FT                   /note="Neurotransmitter-gated ion-channel transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF02932"
SQ   SEQUENCE   500 AA;  57675 MW;  20BD4CBF19614892 CRC64;
     MSFVFFILLT FYIQVKGSVD EYRLLQYLKE NYDSFERPVE NSSAPLDVKV RFLLNQIMDV
     DEKNQVMSIL AYMDYHWNDY KLTWDPKLFG GIRDVRFSGD DDASFKLWRP DVLLFNSVSE
     SFDSTYSSRF IVSSNGDVQQ NPPGIFRFVC QIDVTYYPFD KQTCFLKLGS WTYNGQYINL
     DFLLTQIIGL HGIPIVVEPE RSSTNYASYF VNESIDLQVY LQNGEWDLEG TPGKRVVQKF
     GTDEYHELYF YIHIRRRTLA YGINLIIPSL VISMMTILGF TLPPDACEKI TLETTVLLSV
     IFFLQMVSST SPPQSQSVPI LAAFFSCCLM LVACSCVFTV LTLSLHHRKP ETHEMSPTMR
     KIFIDWLPYI LCMCKPDHPK TPKPKVLGKS IAPIHRLSTI PMLNLPRVSQ TTFPDKNVFV
     YHEVPAVIKN TSRICAELLI IERDIEKMLD KIEEDTKEDM LRSEWRFAAM AVDRLCLYVF
     SAFITMITCG LIVPHILANI
//