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Protein
Submitted name:

ACR-14

Gene

acr-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_312074. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
ACR-14Imported
Gene namesi
Name:acr-14Imported
ORF Names:CELE_T05C12.2Imported, T05C12.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT05C12.2; CE25099; WBGene00000053; acr-14.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi6239.T05C12.2.

Structurei

3D structure databases

SMRiQ22224. Positions 18-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiNOG304378.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ22224.
OMAiMSILAYM.
OrthoDBiEOG72JWGV.
PhylomeDBiQ22224.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 2 hits.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVFFILLT FYIQVKGSVD EYRLLQYLKE NYDSFERPVE NSSAPLDVKV
60 70 80 90 100
RFLLNQIMDV DEKNQVMSIL AYMDYHWNDY KLTWDPKLFG GIRDVRFSGD
110 120 130 140 150
DDASFKLWRP DVLLFNSVSE SFDSTYSSRF IVSSNGDVQQ NPPGIFRFVC
160 170 180 190 200
QIDVTYYPFD KQTCFLKLGS WTYNGQYINL DFLLTQIIGL HGIPIVVEPE
210 220 230 240 250
RSSTNYASYF VNESIDLQVY LQNGEWDLEG TPGKRVVQKF GTDEYHELYF
260 270 280 290 300
YIHIRRRTLA YGINLIIPSL VISMMTILGF TLPPDACEKI TLETTVLLSV
310 320 330 340 350
IFFLQMVSST SPPQSQSVPI LAAFFSCCLM LVACSCVFTV LTLSLHHRKP
360 370 380 390 400
ETHEMSPTMR KIFIDWLPYI LCMCKPDHPK TPKPKVLGKS IAPIHRLSTI
410 420 430 440 450
PMLNLPRVSQ TTFPDKNVFV YHEVPAVIKN TSRICAELLI IERDIEKMLD
460 470 480 490 500
KIEEDTKEDM LRSEWRFAAM AVDRLCLYVF SAFITMITCG LIVPHILANI
Length:500
Mass (Da):57,675
Last modified:April 30, 2000 - v2
Checksum:i20BD4CBF19614892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA91304.2.
PIRiT24504.
RefSeqiNP_495716.1. NM_063315.1.
UniGeneiCel.16093.

Genome annotation databases

EnsemblMetazoaiT05C12.2; T05C12.2; WBGene00000053.
GeneIDi191601.
KEGGicel:CELE_T05C12.2.
UCSCiT05C12.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA91304.2.
PIRiT24504.
RefSeqiNP_495716.1. NM_063315.1.
UniGeneiCel.16093.

3D structure databases

SMRiQ22224. Positions 18-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T05C12.2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05C12.2; T05C12.2; WBGene00000053.
GeneIDi191601.
KEGGicel:CELE_T05C12.2.
UCSCiT05C12.2. c. elegans.

Organism-specific databases

CTDi191601.
WormBaseiT05C12.2; CE25099; WBGene00000053; acr-14.

Phylogenomic databases

eggNOGiNOG304378.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
InParanoidiQ22224.
OMAiMSILAYM.
OrthoDBiEOG72JWGV.
PhylomeDBiQ22224.

Enzyme and pathway databases

ReactomeiREACT_312074. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

Miscellaneous databases

NextBioi949632.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 2 hits.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22224_CAEEL
AccessioniPrimary (citable) accession number: Q22224
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 1996
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.