SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q22224

- Q22224_CAEEL

UniProt

Q22224 - Q22224_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Protein ACR-14
Gene
acr-14, CELE_T05C12.2, T05C12.2
Organism
Caenorhabditis elegans
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channelSAAS annotations, ReceptorSAAS annotations

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein ACR-14Imported
    Gene namesi
    Name:acr-14Imported
    ORF Names:CELE_T05C12.2Imported, T05C12.2Imported
    OrganismiCaenorhabditis elegansImported
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiT05C12.2; CE25099; WBGene00000053; acr-14.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotations, Membrane, Postsynaptic cell membraneSAAS annotations, Synapse

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotations

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T05C12.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22224.
    SMRiQ22224. Positions 18-353.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotations

    Phylogenomic databases

    eggNOGiNOG304378.
    GeneTreeiENSGT00740000115103.
    HOGENOMiHOG000006756.
    InParanoidiQ22224.
    OMAiMSILAYM.
    OrthoDBiEOG72JWGV.
    PhylomeDBiQ22224.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 2 hits.
    SSF90112. SSF90112. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q22224-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFVFFILLT FYIQVKGSVD EYRLLQYLKE NYDSFERPVE NSSAPLDVKV    50
    RFLLNQIMDV DEKNQVMSIL AYMDYHWNDY KLTWDPKLFG GIRDVRFSGD 100
    DDASFKLWRP DVLLFNSVSE SFDSTYSSRF IVSSNGDVQQ NPPGIFRFVC 150
    QIDVTYYPFD KQTCFLKLGS WTYNGQYINL DFLLTQIIGL HGIPIVVEPE 200
    RSSTNYASYF VNESIDLQVY LQNGEWDLEG TPGKRVVQKF GTDEYHELYF 250
    YIHIRRRTLA YGINLIIPSL VISMMTILGF TLPPDACEKI TLETTVLLSV 300
    IFFLQMVSST SPPQSQSVPI LAAFFSCCLM LVACSCVFTV LTLSLHHRKP 350
    ETHEMSPTMR KIFIDWLPYI LCMCKPDHPK TPKPKVLGKS IAPIHRLSTI 400
    PMLNLPRVSQ TTFPDKNVFV YHEVPAVIKN TSRICAELLI IERDIEKMLD 450
    KIEEDTKEDM LRSEWRFAAM AVDRLCLYVF SAFITMITCG LIVPHILANI 500
    Length:500
    Mass (Da):57,675
    Last modified:May 1, 2000 - v2
    Checksum:i20BD4CBF19614892
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66500 Genomic DNA. Translation: CAA91304.2.
    PIRiT24504.
    RefSeqiNP_495716.1. NM_063315.1.
    UniGeneiCel.16093.

    Genome annotation databases

    EnsemblMetazoaiT05C12.2; T05C12.2; WBGene00000053.
    GeneIDi191601.
    KEGGicel:CELE_T05C12.2.
    UCSCiT05C12.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66500 Genomic DNA. Translation: CAA91304.2 .
    PIRi T24504.
    RefSeqi NP_495716.1. NM_063315.1.
    UniGenei Cel.16093.

    3D structure databases

    ProteinModelPortali Q22224.
    SMRi Q22224. Positions 18-353.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 6239.T05C12.2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T05C12.2 ; T05C12.2 ; WBGene00000053 .
    GeneIDi 191601.
    KEGGi cel:CELE_T05C12.2.
    UCSCi T05C12.2. c. elegans.

    Organism-specific databases

    CTDi 191601.
    WormBasei T05C12.2 ; CE25099 ; WBGene00000053 ; acr-14.

    Phylogenomic databases

    eggNOGi NOG304378.
    GeneTreei ENSGT00740000115103.
    HOGENOMi HOG000006756.
    InParanoidi Q22224.
    OMAi MSILAYM.
    OrthoDBi EOG72JWGV.
    PhylomeDBi Q22224.

    Miscellaneous databases

    NextBioi 949632.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 2 hits.
    SSF90112. SSF90112. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiQ22224_CAEEL
    AccessioniPrimary (citable) accession number: Q22224
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: May 1, 2000
    Last modified: July 9, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

    Similar proteinsi