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Protein
Submitted name:

AcetylCholine Receptor

Gene

acr-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Submitted name:
AcetylCholine ReceptorImported
Gene namesi
Name:acr-14Imported
ORF Names:CELE_T05C12.2Imported, T05C12.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT05C12.2 ; CE25099 ; WBGene00000053 ; acr-14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei259 – 278HelicalSequence analysisAdd BLAST20
Transmembranei290 – 308HelicalSequence analysisAdd BLAST19
Transmembranei320 – 345HelicalSequence analysisAdd BLAST26
Transmembranei475 – 497HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500420057518 – 500Sequence analysisAdd BLAST483

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ22224

Expressioni

Gene expression databases

BgeeiWBGene00000053

Interactioni

Protein-protein interaction databases

STRINGi6239.T05C12.2

Structurei

3D structure databases

ProteinModelPortaliQ22224
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 258Neur_chan_LBDInterPro annotationAdd BLAST238
Domaini265 – 491Neur_chan_membInterPro annotationAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili438 – 458Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3646 Eukaryota
ENOG410Z6BY LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
InParanoidiQ22224
OMAiMSILAYM
OrthoDBiEOG091G0R20
PhylomeDBiQ22224

Family and domain databases

Gene3Di2.70.170.101 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 2 hits
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q22224-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVFFILLT FYIQVKGSVD EYRLLQYLKE NYDSFERPVE NSSAPLDVKV
60 70 80 90 100
RFLLNQIMDV DEKNQVMSIL AYMDYHWNDY KLTWDPKLFG GIRDVRFSGD
110 120 130 140 150
DDASFKLWRP DVLLFNSVSE SFDSTYSSRF IVSSNGDVQQ NPPGIFRFVC
160 170 180 190 200
QIDVTYYPFD KQTCFLKLGS WTYNGQYINL DFLLTQIIGL HGIPIVVEPE
210 220 230 240 250
RSSTNYASYF VNESIDLQVY LQNGEWDLEG TPGKRVVQKF GTDEYHELYF
260 270 280 290 300
YIHIRRRTLA YGINLIIPSL VISMMTILGF TLPPDACEKI TLETTVLLSV
310 320 330 340 350
IFFLQMVSST SPPQSQSVPI LAAFFSCCLM LVACSCVFTV LTLSLHHRKP
360 370 380 390 400
ETHEMSPTMR KIFIDWLPYI LCMCKPDHPK TPKPKVLGKS IAPIHRLSTI
410 420 430 440 450
PMLNLPRVSQ TTFPDKNVFV YHEVPAVIKN TSRICAELLI IERDIEKMLD
460 470 480 490 500
KIEEDTKEDM LRSEWRFAAM AVDRLCLYVF SAFITMITCG LIVPHILANI
Length:500
Mass (Da):57,675
Last modified:May 1, 2000 - v2
Checksum:i20BD4CBF19614892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA91304.2
PIRiT24504
RefSeqiNP_495716.1, NM_063315.1
UniGeneiCel.16093

Genome annotation databases

EnsemblMetazoaiT05C12.2; T05C12.2; WBGene00000053
GeneIDi191601
KEGGicel:CELE_T05C12.2
UCSCiT05C12.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ22224_CAEEL
AccessioniPrimary (citable) accession number: Q22224
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported