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Q221U6

- ACDH_RHOFT

UniProt

Q221U6 - ACDH_RHOFT

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Protein

Acetaldehyde dehydrogenase

Gene

Rfer_0455

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
Binding sitei273 – 2731NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1709NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAFER338969:GHU9-457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Rfer_0455
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
ProteomesiUP000008332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Acetaldehyde dehydrogenasePRO_0000387733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_0455.

Structurei

3D structure databases

ProteinModelPortaliQ221U6.
SMRiQ221U6. Positions 1-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OMAiREVQKYV.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q221U6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKKIKCALI GPGNIGTDLL YKLRRSPVLD PVWMVGVDPT SEGLKRAREL
60 70 80 90 100
GLKTTEQGVD GLLPHVLADG VQIAFDATSA YVHAENSRRL TELGVLVIDL
110 120 130 140 150
TPAAIGPFCV PPVNLLALVG RRVMNVNMVT CGGQATIPMI AAISRVQPVR
160 170 180 190 200
YGEIVATISS KSAGPGTRKN IDEFTRTTSR AIEQVGGAAK GKAIIIINPA
210 220 230 240 250
EPPLVMRDTV HCLTETEPDQ AKITASIHAM IKEVQKYVPG YKLVNGPVFD
260 270 280 290 300
DKRVSVFLEV EGLGDFLPKY SGNLDIMTAA AARTAEMFAE EILAGRINLQ

PMATVA
Length:306
Mass (Da):32,752
Last modified:April 18, 2006 - v1
Checksum:iAD9F6AFBD9DD17C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD68207.1.
RefSeqiWP_011462780.1. NC_007908.1.
YP_521738.1. NC_007908.1.

Genome annotation databases

EnsemblBacteriaiABD68207; ABD68207; Rfer_0455.
GeneIDi3963422.
KEGGirfr:Rfer_0455.
PATRICi23233399. VBIRhoFer131161_0725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD68207.1 .
RefSeqi WP_011462780.1. NC_007908.1.
YP_521738.1. NC_007908.1.

3D structure databases

ProteinModelPortali Q221U6.
SMRi Q221U6. Positions 1-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338969.Rfer_0455.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD68207 ; ABD68207 ; Rfer_0455 .
GeneIDi 3963422.
KEGGi rfr:Rfer_0455.
PATRICi 23233399. VBIRhoFer131161_0725.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OMAi REVQKYV.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AFER338969:GHU9-457-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Ivanova N., Richardson P.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-621 / DSM 15236 / T118.

Entry informationi

Entry nameiACDH_RHOFT
AccessioniPrimary (citable) accession number: Q221U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3