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Protein

Acetaldehyde dehydrogenase

Gene

Rfer_0455

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Acyl-thioester intermediateUniRule annotation1
Binding sitei273NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 170NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciAFER338969:GHU9-448-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Rfer_0455
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877331 – 306Acetaldehyde dehydrogenaseAdd BLAST306

Proteomic databases

PRIDEiQ221U6

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_0455

Structurei

3D structure databases

ProteinModelPortaliQ221U6
SMRiQ221U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK18366
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

Q221U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKIKCALI GPGNIGTDLL YKLRRSPVLD PVWMVGVDPT SEGLKRAREL
60 70 80 90 100
GLKTTEQGVD GLLPHVLADG VQIAFDATSA YVHAENSRRL TELGVLVIDL
110 120 130 140 150
TPAAIGPFCV PPVNLLALVG RRVMNVNMVT CGGQATIPMI AAISRVQPVR
160 170 180 190 200
YGEIVATISS KSAGPGTRKN IDEFTRTTSR AIEQVGGAAK GKAIIIINPA
210 220 230 240 250
EPPLVMRDTV HCLTETEPDQ AKITASIHAM IKEVQKYVPG YKLVNGPVFD
260 270 280 290 300
DKRVSVFLEV EGLGDFLPKY SGNLDIMTAA AARTAEMFAE EILAGRINLQ

PMATVA
Length:306
Mass (Da):32,752
Last modified:April 18, 2006 - v1
Checksum:iAD9F6AFBD9DD17C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA Translation: ABD68207.1
RefSeqiWP_011462780.1, NC_007908.1

Genome annotation databases

EnsemblBacteriaiABD68207; ABD68207; Rfer_0455
KEGGirfr:Rfer_0455

Similar proteinsi

Entry informationi

Entry nameiACDH_RHOFT
AccessioniPrimary (citable) accession number: Q221U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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