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Protein

Chemotaxis response regulator protein-glutamate methylesterase 1

Gene

cheB1

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei187UniRule annotation1
Active sitei213UniRule annotation1
Active sitei309UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 1UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB1UniRule annotation
Ordered Locus Names:Rfer_0571
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi
  • UP000008332 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643041 – 373Chemotaxis response regulator protein-glutamate methylesterase 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei674-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_0571.

Structurei

3D structure databases

ProteinModelPortaliQ221I1.
SMRiQ221I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 133Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini175 – 367CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q221I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARWICFEDI ELKKIRVVVV DDSALVRSLL AEIINRQKDM ECVGTANDPL
60 70 80 90 100
IAREMIRELN PDVLTLDIEM PRMDGIDFLG RLMRLRPMPV VMVSTLTERG
110 120 130 140 150
AEITMKALEL GAIDFVAKPR IGVASGLTEL SDQIVEKVRI AATAHVRRAP
160 170 180 190 200
AVPAAATPAV GGAVGGHAPV ASIGRVSTEK LICIGASTGG TEAIKEILTR
210 220 230 240 250
LPADSPGIVI TQHMPPGFTT SFAARLNSLC QIAVQEAVNG ERILPGHAYI
260 270 280 290 300
APGGKQFRVS RSGANYVALV EDGELVNRHK PSVEVLFKSV ASVVGRNAYG
310 320 330 340 350
VMLTGMGNDG AKAMREMKDA GSYNFVQDEA SCIVFGMPRE AILHGAADEV
360 370
LPLTAIAPAL IAKLSSATDR YRV
Length:373
Mass (Da):39,828
Last modified:April 18, 2006 - v1
Checksum:iA8C006434395A54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA. Translation: ABD68322.1.

Genome annotation databases

EnsemblBacteriaiABD68322; ABD68322; Rfer_0571.
KEGGirfr:Rfer_0571.

Similar proteinsi

Entry informationi

Entry nameiCHEB1_RHOFT
AccessioniPrimary (citable) accession number: Q221I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: April 18, 2006
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome