Q22181 (UGT56_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative UDP-glucuronosyltransferase ugt-56
Short name=UDPGT 56
EC=2.4.1.17

Gene names

Name:	ugt-56
Synonyms:	ugt12
ORF Names:	T04H1.8

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 524	504	Putative UDP-glucuronosyltransferase ugt-56		PRO_0000036052
Regions
	Transmembrane	488 – 508	21	Helical; Potential
Amino acid modifications
	Glycosylation	125	1	N-linked (GlcNAc...) Potential
	Glycosylation	277	1	N-linked (GlcNAc...) Potential
	Glycosylation	335	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q22181 [UniParc]. Last modified April 11, 2003. Version 2. Checksum: 2CDA85E24BBDF3CC	FASTA	524	59,284
	10 20 30 40 50 60 MLWAFIVWLG ALCIYGSAFD ILIYAPRMMQ SHVYFTARIA NVLAARGHKV TVIDNVFRYD 70 80 90 100 110 120 VDNELSSDIH EIISVEPSPE VTKLLNTGSL PTILWNSKAS PEEQRTIMEG LGHVHRLQCT 130 140 150 160 170 180 HLIENSTLIP KLQEIKFDFA IHEVFDSCGV GILEVIGVQK TVIVSSTGPM DVVPITLGIS 190 200 210 220 230 240 DTLNTPSLLS DYGSYLSFFE KRRNLKFLSG MLNFHEMQDS MISPLFKKYY GLKKPTGEIM 250 260 270 280 290 300 RQANLLFYNI HEGSDGMRMR GRRSFDIGGI AFKDQKNLTM EYQTLLSDPR PKVLVSFGTA 310 320 330 340 350 360 ATSSHMPQNL KNSLMTAMKQ MNNVLFIWKY EMEDNFTKQE ELTTNIIFKK FLPQTDLLAS 370 380 390 400 410 420 SKIDLFVTHC GQNSLLEAFN SGVRVLAVPL FGDQHRNAKL AFENGLIEIL PKSDIETPAK 430 440 450 460 470 480 IVKAVKTGLE PNAKLDQNIV LISSLLRNSK ENAENLLIST IEATYSTEFP PNFSKFPKNY 490 500 510 520 HPNTLVRLID SSIALVFMLF IFVFVNHFRK NYVGFKYPLS FSTK

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z78200 Genomic DNA. Translation: CAB01585.2.
PIR	T24478.
RefSeq	NP_506074.2. NM_073673.3.
UniGene	Cel.2497.
3D structure databases
ProteinModelPortal	Q22181.
SMR	Q22181. Positions 273-448.
ModBase	Search...
Protein-protein interaction databases
STRING	Q22181.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T04H1.8; T04H1.8; T04H1.8.
GeneID	188073.
KEGG	cel:T04H1.8.
NMPDR	fig|6239.3.peg.19955.
UCSC	T04H1.8. c. elegans.
Organism-specific databases
CTD	188073.
WormBase	T04H1.8; CE31985; WBGene00011453; ugt-56.
Phylogenomic databases
eggNOG	KOG1192.
GeneTree	EMGT00050000003212.
HOGENOM	HBG385462.
InParanoid	Q22181.
OMA	ATSSHMP.
PhylomeDB	Q22181.
Gene expression databases
ArrayExpress	Q22181.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
KO	K00699.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	937504.

Entry information

Entry name

UGT56_CAEEL

Accession

Primary (citable) accession number: Q22181

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	April 11, 2003
Last modified:	December 14, 2011
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project