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Protein
Submitted name:

CaLPain family

Gene

clp-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC02.029.

Names & Taxonomyi

Protein namesi
Submitted name:
CaLPain familyImported
Gene namesi
Name:clp-2Imported
ORF Names:CELE_T04A8.16Imported, T04A8.16Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT04A8.16; CE01070; WBGene00000543; clp-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ22143.
PeptideAtlasiQ22143.

Expressioni

Gene expression databases

BgeeiWBGene00000543.

Interactioni

Protein-protein interaction databases

IntActiQ22143. 1 interactor.
STRINGi6239.T04A8.16.

Structurei

3D structure databases

ProteinModelPortaliQ22143.
SMRiQ22143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini266 – 544Calpain catalyticInterPro annotationAdd BLAST279

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
InParanoidiQ22143.
KOiK08576.
OMAiPIYQFHI.
OrthoDBiEOG091G023Z.
PhylomeDBiQ22143.

Family and domain databases

CDDicd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00230. CysPc. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKATQSAF ELSQKAVYYD QGKKYEEAIF CYTEAGNQLL RLVQEKKCLP
60 70 80 90 100
IFRKNVMECI NRAEFLKSNI QNLQQQYPPT TDDIAHNVEY LMVKAAVFQN
110 120 130 140 150
YENQVDEARQ VYENVVEQCL GASRNRTLPQ ETLKRLRSTA ENALKCIEDL
160 170 180 190 200
VALKKKVTEV ELLFPEVPVD DLSNLNFNNQ PSPSTPSNQP FKSPTRNFPP
210 220 230 240 250
SPSNSQKFTK EELAVLFTTS NINNKLYVPF HNYDKVNEFK GQQGKFTDPE
260 270 280 290 300
GKISLTQKQR MKLKCWKRVS ELFENPTIIF SIDCHTIKQT VISDCSFISS
310 320 330 340 350
LSIAALYEKR FKKQLVTSII FPQDANGKPI YNPAGKYMFK FHLNGAWRKV
360 370 380 390 400
LIDDYFPVDE NNRMMCSQTE NKGELWVSLL EKAYMKVMGG YDFPGSNSNI
410 420 430 440 450
DLNALTGWIP ERIELSDTSK ADPDEVFRKL FDRFHRGDCL ITLATGKMTE
460 470 480 490 500
DMQKRSGLVE THAYAVIDIR CVETKRLLKV KNPWTHSRWK GNFSDKDKVN
510 520 530 540 550
WTAKMKNALA FDPEVAAEKD DGIFWIDYES VRHFFDVIYV NWNADLFPFK
560 570 580 590 600
SVYHATWTQD TGPIRDVYTV GENPQYTLTV NLNQKAAAVW ILLTRHITAI
610 620 630 640 650
DDFAVNKEFI TLIVYETGQK IYIPSNPQPI SDGVRINSPL YLCQLSNKKP
660 670 680 690 700
GITKYTLVVA QYEKTNTINY SLRVFSTTDV KLEPVQLPYS ISKTTRGNWD
710 720 730 740 750
GSDKYPIMKL TLHSKSDEIA LFMELKAPKQ FCVALEMKQN SSDRTVFLET
760 770 780 790 800
KSSGAYRPGY TVLTLEKVPA GKYYVKISTY TAGDKGPFIL RIDSTCKFDL

EPIKL
Length:805
Mass (Da):92,387
Last modified:November 1, 1996 - v1
Checksum:iB923E8BFAE18EEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA84733.1.
PIRiT24431.
RefSeqiNP_497964.1. NM_065563.3.
UniGeneiCel.5995.

Genome annotation databases

EnsemblMetazoaiT04A8.16; T04A8.16; WBGene00000543.
GeneIDi175618.
KEGGicel:CELE_T04A8.16.
UCSCiT04A8.16. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAA84733.1.
PIRiT24431.
RefSeqiNP_497964.1. NM_065563.3.
UniGeneiCel.5995.

3D structure databases

ProteinModelPortaliQ22143.
SMRiQ22143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22143. 1 interactor.
STRINGi6239.T04A8.16.

Protein family/group databases

MEROPSiC02.029.

Proteomic databases

PaxDbiQ22143.
PeptideAtlasiQ22143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT04A8.16; T04A8.16; WBGene00000543.
GeneIDi175618.
KEGGicel:CELE_T04A8.16.
UCSCiT04A8.16. c. elegans.

Organism-specific databases

CTDi175618.
WormBaseiT04A8.16; CE01070; WBGene00000543; clp-2.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
InParanoidiQ22143.
KOiK08576.
OMAiPIYQFHI.
OrthoDBiEOG091G023Z.
PhylomeDBiQ22143.

Gene expression databases

BgeeiWBGene00000543.

Family and domain databases

CDDicd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00230. CysPc. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ22143_CAEEL
AccessioniPrimary (citable) accession number: Q22143
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.