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Q220P5

- SYL_ALBFT

UniProt

Q220P5 - SYL_ALBFT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei643 – 6431ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAFER338969:GHU9-761-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Rfer_0758
    OrganismiAlbidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
    Taxonomic identifieri338969 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
    ProteomesiUP000008332: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Leucine--tRNA ligasePRO_1000009408Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338969.Rfer_0758.

    Structurei

    3D structure databases

    ProteinModelPortaliQ220P5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi640 – 6445"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q220P5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEKYTPLDV EQAAQSHWTA MDAYRVTEDS SKKKFYACSM LPYPSGKLHM    50
    GHVRNYTIND MLTRYLRMNG YNVLMPMGWD AFGLPAENAA LKNGVPPAQW 100
    TFENIAYMKQ QMQAMGLAID WSREVATCDP SYYKWNQWLF LKMLDKGIAY 150
    RKTQVVNWDP VDQTVLANEQ VIDGKGWRTG ATVEKREIPG YYLKITDYAE 200
    ELLGQVQTGL PGWPERVKLM QENWIGKSEG VRFAFTHDIR DASGALIDDG 250
    RMYVFTTRPD TIKGVTFCAV APEHPLALHA ARGNPALAAF IEECKTGGTT 300
    EAELATQEKK GLDTGLIVTH PLTQLPVAVW VGNYVLMSYG DGAVMGVPAH 350
    DERDFAFAKK YGLPIKQVVQ VDGEQFDYDQ WQDWYADKQR GVAINSGSFS 400
    GMSFKQAVEA VAHKLAALGL GEKKTTWRLR DWGVSRQRYW GTPIPIIHCP 450
    EHGAVPVPEK DLPVVLPQDC VPDGSGNPLH KHEGFHAGVV CPICGVAARR 500
    ETDTMDTFVD SSWYFMRYCD PKNEKAMVGE GAAYWMPMDQ YIGGIEHAIL 550
    HLLYARFWTK VMRDLGLVKV DEPFTKLLTQ GMVLNHIYSR KGENGAKDYF 600
    WPNDVENVSD ETGKVVAAKL KVAVGNLPAG TLVDYEGIGT MSKSKNNGVD 650
    PQDLIERYGA DTARLYTMFT APPEATLEWN DAAVEGSYRF LRRVWNFGIK 700
    LSTIDMIAVD ESTTGATALN DINFSKEAKV LRLEIHTVLK QVDYDYQRMQ 750
    YNTVVSGAMK MINALENFKA TDSGGAQVAL IEGFGILLRC LYPATPHIAH 800
    SLWQGLGYAG TLGDLLDAPW PQVDELALLQ DEVELMLQIN GKLRGAIVVS 850
    AGASKVEIEL AAIDSEVFRK LANGATPKKV IVVPGRLVNL VV 892
    Length:892
    Mass (Da):99,291
    Last modified:April 18, 2006 - v1
    Checksum:i1C6F17513F50E8A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000267 Genomic DNA. Translation: ABD68508.1.
    RefSeqiYP_522039.1. NC_007908.1.

    Genome annotation databases

    EnsemblBacteriaiABD68508; ABD68508; Rfer_0758.
    GeneIDi3964136.
    KEGGirfr:Rfer_0758.
    PATRICi23234029. VBIRhoFer131161_1039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000267 Genomic DNA. Translation: ABD68508.1 .
    RefSeqi YP_522039.1. NC_007908.1.

    3D structure databases

    ProteinModelPortali Q220P5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338969.Rfer_0758.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD68508 ; ABD68508 ; Rfer_0758 .
    GeneIDi 3964136.
    KEGGi rfr:Rfer_0758.
    PATRICi 23234029. VBIRhoFer131161_1039.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AFER338969:GHU9-761-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.
      , Kyrpides N., Ivanova N., Richardson P.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-621 / DSM 15236 / T118.

    Entry informationi

    Entry nameiSYL_ALBFT
    AccessioniPrimary (citable) accession number: Q220P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3