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Q220P5

- SYL_ALBFT

UniProt

Q220P5 - SYL_ALBFT

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Protein

Leucine--tRNA ligase

Gene
leuS, Rfer_0758
Organism
Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei643 – 6431ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFER338969:GHU9-761-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Rfer_0758
OrganismiAlbidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
ProteomesiUP000008332: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Leucine--tRNA ligaseUniRule annotationPRO_1000009408Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_0758.

Structurei

3D structure databases

ProteinModelPortaliQ220P5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi640 – 6445"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q220P5-1 [UniParc]FASTAAdd to Basket

« Hide

MQEKYTPLDV EQAAQSHWTA MDAYRVTEDS SKKKFYACSM LPYPSGKLHM    50
GHVRNYTIND MLTRYLRMNG YNVLMPMGWD AFGLPAENAA LKNGVPPAQW 100
TFENIAYMKQ QMQAMGLAID WSREVATCDP SYYKWNQWLF LKMLDKGIAY 150
RKTQVVNWDP VDQTVLANEQ VIDGKGWRTG ATVEKREIPG YYLKITDYAE 200
ELLGQVQTGL PGWPERVKLM QENWIGKSEG VRFAFTHDIR DASGALIDDG 250
RMYVFTTRPD TIKGVTFCAV APEHPLALHA ARGNPALAAF IEECKTGGTT 300
EAELATQEKK GLDTGLIVTH PLTQLPVAVW VGNYVLMSYG DGAVMGVPAH 350
DERDFAFAKK YGLPIKQVVQ VDGEQFDYDQ WQDWYADKQR GVAINSGSFS 400
GMSFKQAVEA VAHKLAALGL GEKKTTWRLR DWGVSRQRYW GTPIPIIHCP 450
EHGAVPVPEK DLPVVLPQDC VPDGSGNPLH KHEGFHAGVV CPICGVAARR 500
ETDTMDTFVD SSWYFMRYCD PKNEKAMVGE GAAYWMPMDQ YIGGIEHAIL 550
HLLYARFWTK VMRDLGLVKV DEPFTKLLTQ GMVLNHIYSR KGENGAKDYF 600
WPNDVENVSD ETGKVVAAKL KVAVGNLPAG TLVDYEGIGT MSKSKNNGVD 650
PQDLIERYGA DTARLYTMFT APPEATLEWN DAAVEGSYRF LRRVWNFGIK 700
LSTIDMIAVD ESTTGATALN DINFSKEAKV LRLEIHTVLK QVDYDYQRMQ 750
YNTVVSGAMK MINALENFKA TDSGGAQVAL IEGFGILLRC LYPATPHIAH 800
SLWQGLGYAG TLGDLLDAPW PQVDELALLQ DEVELMLQIN GKLRGAIVVS 850
AGASKVEIEL AAIDSEVFRK LANGATPKKV IVVPGRLVNL VV 892
Length:892
Mass (Da):99,291
Last modified:April 18, 2006 - v1
Checksum:i1C6F17513F50E8A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD68508.1.
RefSeqiYP_522039.1. NC_007908.1.

Genome annotation databases

EnsemblBacteriaiABD68508; ABD68508; Rfer_0758.
GeneIDi3964136.
KEGGirfr:Rfer_0758.
PATRICi23234029. VBIRhoFer131161_1039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD68508.1 .
RefSeqi YP_522039.1. NC_007908.1.

3D structure databases

ProteinModelPortali Q220P5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338969.Rfer_0758.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD68508 ; ABD68508 ; Rfer_0758 .
GeneIDi 3964136.
KEGGi rfr:Rfer_0758.
PATRICi 23234029. VBIRhoFer131161_1039.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci AFER338969:GHU9-761-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Ivanova N., Richardson P.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-621 / DSM 15236 / T118.

Entry informationi

Entry nameiSYL_ALBFT
AccessioniPrimary (citable) accession number: Q220P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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