Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-18

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-18Imported
ORF Names:CELE_T01H10.7Imported, T01H10.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01H10.7; CE40816; WBGene00011360; lgc-18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei260 – 28223HelicalSequence analysisAdd
BLAST
Transmembranei291 – 30919HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34525HelicalSequence analysisAdd
BLAST
Transmembranei366 – 39631HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ22084.

Interactioni

Protein-protein interaction databases

STRINGi6239.T01H10.7.

Structurei

3D structure databases

ProteinModelPortaliQ22084.
SMRiQ22084. Positions 32-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 258223Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22084.
OMAiSQIYEGI.
OrthoDBiEOG7G7KSZ.
PhylomeDBiQ22084.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVLIFAII EITTCFYQNE SLYVPEWNNF LENQVKLIKD VFTNYDNTLS
60 70 80 90 100
PVYTKIDPTQ PIGYNPLAPK RFNYTVSLYY LKLVEVIEPE EKVSVVLEMA
110 120 130 140 150
EYWYDPRIAW DSSLYGDIKM LHMRQDKVWS PTLSLFRIND IADFRDPDFR
160 170 180 190 200
MVCVENTGHT YTTLSVKISL NCPLDVSMFP YDSQTCRIQF NMPLFFMQQV
210 220 230 240 250
EMFSQIYEGI LNSTVWEKMG NSEWELANLT HSVELLSYGD GLGDMQLATF
260 270 280 290 300
EIRIRRNPMY YIYMIIFPSF IINALSIIGV FLKKTDKMSK LNVGLTNIMT
310 320 330 340 350
MTFILGVMAD KIPKTGSIPL LGIYIIVNLF IMIVAVGLTI VLAEIQKCAI
360 370 380 390
PKLRKNKSKM NQKLEYVLGE PLETICMVIL EIFNTAIFMV MIGFWINDI
Length:399
Mass (Da):46,319
Last modified:May 1, 2007 - v3
Checksum:i6FFEFF841B967D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91540.3.
PIRiT24328.
RefSeqiNP_510029.3. NM_077628.3.
UniGeneiCel.36527.

Genome annotation databases

EnsemblMetazoaiT01H10.7; T01H10.7; WBGene00011360.
GeneIDi187977.
KEGGicel:CELE_T01H10.7.
UCSCiT01H10.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91540.3.
PIRiT24328.
RefSeqiNP_510029.3. NM_077628.3.
UniGeneiCel.36527.

3D structure databases

ProteinModelPortaliQ22084.
SMRiQ22084. Positions 32-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01H10.7.

Proteomic databases

PaxDbiQ22084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01H10.7; T01H10.7; WBGene00011360.
GeneIDi187977.
KEGGicel:CELE_T01H10.7.
UCSCiT01H10.7. c. elegans.

Organism-specific databases

CTDi187977.
WormBaseiT01H10.7; CE40816; WBGene00011360; lgc-18.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22084.
OMAiSQIYEGI.
OrthoDBiEOG7G7KSZ.
PhylomeDBiQ22084.

Miscellaneous databases

NextBioi937158.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22084_CAEEL
AccessioniPrimary (citable) accession number: Q22084
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.