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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-14

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-14Imported
ORF Names:CELE_T01H10.2Imported, T01H10.2Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01H10.2; CE36662; WBGene00011355; lgc-14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei260 – 28223HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34525HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39625HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ22080.

Expressioni

Gene expression databases

BgeeiWBGene00011355.

Structurei

3D structure databases

ProteinModelPortaliQ22080.
SMRiQ22080. Positions 29-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 257223Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22080.
OMAiYDYISVR.
OrthoDBiEOG091G0CMK.
PhylomeDBiQ22080.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFVTFTVIF IGSHALYYNP ELYVPKYHDF IESQTNLTRD LFNGYDPTVS
60 70 80 90 100
PVYSKIDPLQ PLGYDPDAPK RYNYSIMLYS LKLVEVNEPA EKVAVVMEIM
110 120 130 140 150
EYWYDIRLSW NASLYDDIDT FYTRQSNVWS PTLSAFGADE LVDLRDPDFR
160 170 180 190 200
MVCVNSNGYI YDYISVRVSS SCPMNVYKFP FDYQTCQIKF CLPIFNSVEI
210 220 230 240 250
QIFNEIYVGV LMSDLWETMG NSEWKLTNLS NRVETLQYND GFGNLDLGIF
260 270 280 290 300
EITIKRNPLY YIYMIIFPSF IINVVSIIGV FLKGADKMSR LNVGLTNIMT
310 320 330 340 350
MTFILGVMAD KIPRTGTIPM LGVYIIVNLA IMIIAIGIVT MITELRHWLA
360 370 380 390 400
PFLKRNETKF SRKLETFIGP PLEFTCAIIL EVFTCAIFGV MIGFWLGDDK
Length:400
Mass (Da):46,143
Last modified:September 13, 2004 - v3
Checksum:i16515D62CD6EA7BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91537.3.
PIRiT24325.
RefSeqiNP_510024.2. NM_077623.2.
UniGeneiCel.438.

Genome annotation databases

EnsemblMetazoaiT01H10.2; T01H10.2; WBGene00011355.
GeneIDi187972.
KEGGicel:CELE_T01H10.2.
UCSCiT01H10.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91537.3.
PIRiT24325.
RefSeqiNP_510024.2. NM_077623.2.
UniGeneiCel.438.

3D structure databases

ProteinModelPortaliQ22080.
SMRiQ22080. Positions 29-351.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ22080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01H10.2; T01H10.2; WBGene00011355.
GeneIDi187972.
KEGGicel:CELE_T01H10.2.
UCSCiT01H10.2. c. elegans.

Organism-specific databases

CTDi187972.
WormBaseiT01H10.2; CE36662; WBGene00011355; lgc-14.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22080.
OMAiYDYISVR.
OrthoDBiEOG091G0CMK.
PhylomeDBiQ22080.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Gene expression databases

BgeeiWBGene00011355.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ22080_CAEEL
AccessioniPrimary (citable) accession number: Q22080
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: September 13, 2004
Last modified: September 7, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.