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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-13

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-13Imported
ORF Names:CELE_T01H10.1Imported, T01H10.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01H10.1; CE35609; WBGene00011354; lgc-13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei260 – 28223HelicalSequence analysisAdd
BLAST
Transmembranei291 – 30919HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34525HelicalSequence analysisAdd
BLAST
Transmembranei366 – 39631HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 399383Sequence analysisPRO_5004200531Add
BLAST

Proteomic databases

PaxDbiQ22079.

Interactioni

Protein-protein interaction databases

STRINGi6239.T01H10.1.

Structurei

3D structure databases

ProteinModelPortaliQ22079.
SMRiQ22079. Positions 33-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 257221Neur_chan_LBDInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22079.
OMAiRNPLYYF.
OrthoDBiEOG7ZGX6Z.
PhylomeDBiQ22079.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTFILLKL ILSTDAFYYD PQLYVPKYRD YLEAQGNLTA DLFKNYEKDV
60 70 80 90 100
SPVYAWFDTS KPLGYDPDAP QRYNYTLFLY NLKLIQVNEP EEQVSVVLEL
110 120 130 140 150
MEYWYDPRLS WNASDYKNVT AIFTRQEKIW SPTLTPFGVN EIIDFRDQDF
160 170 180 190 200
RLVCIDNLGM IYDYLSVRVS ANCRMDVTKF PFDSQTCQIR FSLPIFSYLE
210 220 230 240 250
VKIYTELYEG INNYSMFEVM GNSEWELINL TNRVDFLTYN DRFDVELAVY
260 270 280 290 300
EIKIARNPLY YFYMIVFPSF VINSVSIVGV FIKGADKMSR LNVGLTNIMT
310 320 330 340 350
MTFILGVMSD KIPRTGNVPL LGIYIIVNLL IMLVAIIIVT IITEIRKCVT
360 370 380 390
PKLRKNTSSF NLKLEIFIGS PLEYTCAVIL ELATISNFFM MIGFWIDNS
Length:399
Mass (Da):46,562
Last modified:July 5, 2004 - v2
Checksum:iF88B8698883EA81F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91536.2.
PIRiT24324.
RefSeqiNP_510023.2. NM_077622.2.
UniGeneiCel.439.

Genome annotation databases

EnsemblMetazoaiT01H10.1; T01H10.1; WBGene00011354.
GeneIDi187971.
KEGGicel:CELE_T01H10.1.
UCSCiT01H10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA91536.2.
PIRiT24324.
RefSeqiNP_510023.2. NM_077622.2.
UniGeneiCel.439.

3D structure databases

ProteinModelPortaliQ22079.
SMRiQ22079. Positions 33-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01H10.1.

Proteomic databases

PaxDbiQ22079.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01H10.1; T01H10.1; WBGene00011354.
GeneIDi187971.
KEGGicel:CELE_T01H10.1.
UCSCiT01H10.1. c. elegans.

Organism-specific databases

CTDi187971.
WormBaseiT01H10.1; CE35609; WBGene00011354; lgc-13.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000015989.
InParanoidiQ22079.
OMAiRNPLYYF.
OrthoDBiEOG7ZGX6Z.
PhylomeDBiQ22079.

Enzyme and pathway databases

ReactomeiR-CEL-975298. Ligand-gated ion channel transport.

Family and domain databases

Gene3Di1.20.120.370. 1 hit.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
PRINTSiPR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22079_CAEEL
AccessioniPrimary (citable) accession number: Q22079
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.