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Protein
Submitted name:

Uncharacterized protein

Gene

mec-15

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • acetylcholine transport Source: UniProtKB
  • detection of mechanical stimulus involved in sensory perception of touch Source: UniProtKB
  • detection of temperature stimulus involved in sensory perception Source: UniProtKB
  • mechanosensory behavior Source: UniProtKB
  • neuron development Source: WormBase
  • positive regulation of detection of mechanical stimulus involved in sensory perception of touch Source: UniProtKB
  • positive regulation of inhibitory postsynaptic potential Source: UniProtKB
  • positive regulation of mechanosensory behavior Source: UniProtKB
  • positive regulation of muscle contraction Source: UniProtKB
  • positive regulation of synaptic transmission, GABAergic Source: UniProtKB
  • positive regulation of synaptic vesicle transport Source: WormBase
  • synaptic vesicle targeting Source: UniProtKB
  • thermosensory behavior Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ22071.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:mec-15Imported
ORF Names:CELE_T01E8.4Imported, T01E8.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT01E8.4; CE02308; WBGene00003177; mec-15.

Subcellular locationi

GO - Cellular componenti

  • perikaryon Source: UniProtKB
  • presynapse Source: GOC

PTM / Processingi

Proteomic databases

EPDiQ22071.
PaxDbiQ22071.
PeptideAtlasiQ22071.

Expressioni

Gene expression databases

BgeeiWBGene00003177.

Interactioni

Protein-protein interaction databases

STRINGi6239.T01E8.4.1.

Structurei

3D structure databases

ProteinModelPortaliQ22071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 53F-boxInterPro annotationAdd BLAST48
Domaini99 – 195WD_REPEATS_REGIONInterPro annotationAdd BLAST97
Repeati99 – 142WDPROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQD3. Eukaryota.
ENOG4111G8F. LUCA.
GeneTreeiENSGT00390000006806.
HOGENOMiHOG000021824.
InParanoidiQ22071.
KOiK10265.
OMAiWCASHEL.
OrthoDBiEOG091G0AVG.
PhylomeDBiQ22071.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q22071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNAQPTELI SLPSELLCHL FTYLPQRQLI TEIPLVCRRF NTILNDDKFW
60 70 80 90 100
SRRIRTEQKV RLPDCELKHP EYEPKKSFYA MHRQRDRWRA WETQTVITAP
110 120 130 140 150
GHSATVDSVM LFENNNKQFC LSGSRDRTIR LWSIENARNG EDTEQNPWTV
160 170 180 190 200
AKDDTAHSGW IWNMAQESTS TNFYTTSWDS TVKSWHITDN GALQNLNSVN
210 220 230 240 250
VGSAAQCISC SGNENEVVCT TFAKRVAVID SRTFQVVADH KLHKRAVIAL
260 270 280 290 300
AVQGDKIFTS GEDRLMMMVD RRNFSKPVLF EYSPTAYKSC LSLQCNQLLT
310 320 330 340 350
STSDGKVKLY DANNFNVLQT YSVGSYTRQS FLEHGAHLIM ARSLKRNYTF
360 370 380 390 400
SIYSPGTRSQ QWCASHELAA EPAKFDYSPS SRTLAIGNGD SSILFCLPAS

APDQEN
Length:406
Mass (Da):46,173
Last modified:November 1, 1996 - v1
Checksum:iD3B5F68B370C6F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88747.1.
PIRiT24301.
RefSeqiNP_496207.1. NM_063806.6.
UniGeneiCel.14496.

Genome annotation databases

EnsemblMetazoaiT01E8.4; T01E8.4; WBGene00003177.
GeneIDi174587.
KEGGicel:CELE_T01E8.4.
UCSCiT01E8.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88747.1.
PIRiT24301.
RefSeqiNP_496207.1. NM_063806.6.
UniGeneiCel.14496.

3D structure databases

ProteinModelPortaliQ22071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01E8.4.1.

Proteomic databases

EPDiQ22071.
PaxDbiQ22071.
PeptideAtlasiQ22071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01E8.4; T01E8.4; WBGene00003177.
GeneIDi174587.
KEGGicel:CELE_T01E8.4.
UCSCiT01E8.4. c. elegans.

Organism-specific databases

CTDi174587.
WormBaseiT01E8.4; CE02308; WBGene00003177; mec-15.

Phylogenomic databases

eggNOGiENOG410IQD3. Eukaryota.
ENOG4111G8F. LUCA.
GeneTreeiENSGT00390000006806.
HOGENOMiHOG000021824.
InParanoidiQ22071.
KOiK10265.
OMAiWCASHEL.
OrthoDBiEOG091G0AVG.
PhylomeDBiQ22071.

Enzyme and pathway databases

ReactomeiR-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ22071.

Gene expression databases

BgeeiWBGene00003177.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ22071_CAEEL
AccessioniPrimary (citable) accession number: Q22071
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.