Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide phospholipase C

Gene

plc-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • phospholipid catabolic process Source: InterPro
  • sleep Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-114604. GPVI-mediated activation cascade.
R-CEL-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-CEL-202433. Generation of second messenger molecules.
R-CEL-5607764. CLEC7A (Dectin-1) signaling.
SignaLinkiQ22070.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:plc-3Imported
ORF Names:CELE_T01E8.3Imported, T01E8.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiT01E8.3; CE42905; WBGene00004038; plc-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ22070.
PaxDbiQ22070.
PRIDEiQ22070.

Expressioni

Gene expression databases

BgeeiWBGene00004038.

Interactioni

Protein-protein interaction databases

IntActiQ22070. 2 interactions.
STRINGi6239.T01E8.3.

Structurei

3D structure databases

ProteinModelPortaliQ22070.
SMRiQ22070. Positions 279-495, 600-897, 981-1237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 503152PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini605 – 704100SH2InterPro annotationAdd
BLAST
Domaini715 – 80490SH2InterPro annotationAdd
BLAST
Domaini832 – 89059SH3InterPro annotationAdd
BLAST
Domaini855 – 960106PHInterPro annotationAdd
BLAST
Domaini982 – 1092111PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini1098 – 1203106C2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
GeneTreeiENSGT00730000110782.
HOGENOMiHOG000230864.
InParanoidiQ22070.
KOiK01116.
OMAiPANREEK.
OrthoDBiEOG091G07R3.
PhylomeDBiQ22070.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 3 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHGSLGPSS SSRKTTVTST AGSVHLHHRS SNGFSTASRA QLNRHNEMDF
60 70 80 90 100
GKMFAAMEKG HKVCKIAVLK KWDPAYKQLT LDRYSRQIFL TKLELSAVRN
110 120 130 140 150
KPTILDIRQI REVQTLNYKL NTIKVDDKWK KDREIVNFDS KAILIISYGM
160 170 180 190 200
GFALSYWILL FESEDACKLW SQGLHNLMMD TRDRDSSPHP LRIERFLHKH
210 220 230 240 250
FLSLMSPAND AVARKHMKPF VQTSLQFKVQ SDQLQQVTED QMNSDQFSFA
260 270 280 290 300
SRQLIHVPEL FSSRFADLAE KHERKGLVVT FQNFLRFLDG KQFDELASNR
310 320 330 340 350
TRALEFLNRY FQEDQAYFGD RNEPSMTVFE FCDFLFSREN SLWDPTNEKV
360 370 380 390 400
THDMSRPLSH YWIASSHNTY LTGDQLRSES SLDCYAQALL MGCRCIELDC
410 420 430 440 450
WDGQKKPGSA EFIDIVIYHG YTMTSKILLR DVLHVIRHYA FVTSEYPVIL
460 470 480 490 500
SIEDNCSVPA QRLLAQELKD ILGDYLLTQP ANREEKQLPS PAALKKKIIV
510 520 530 540 550
KHKKLPIESE DLAAVVKTDE FQDTEIISRE CVKKGILMVK NNNSHEWTSH
560 570 580 590 600
VFILFPDRLC YLIQTADPEN PNDDTVSVSG DEEREEETPS GFGVKPEEMH
610 620 630 640 650
VTEEWFHGRC ERDEAKKRIL EHKEKGNGLF MIRDSNLFIG DFSLSILHDG
660 670 680 690 700
KVHHVRIRSK IIDKEKKYYF MDNKVCDTLY ELVSYYTRHY LTTAHFKMVL
710 720 730 740 750
TIPCPQPQPH LNQPWFSATA DKEKAEELLS LVPEDGAFLI RTSSTDSSVY
760 770 780 790 800
VLSLKVDGEF WHYRLKRDGR IFVVNQKVFE NLNQIVEFYA NREFVRGISL
810 820 830 840 850
RFPVNEKDIS HLTAELAEAR TPGCYMDLKD LDKEVQARAL RPYRGTADDE
860 870 880 890 900
LSFPANVIIT VLRKEEGLWR GRYGSLTGWF PSAHVQEILP EKVSTSETSN
910 920 930 940 950
YNTIELAGTL IERIHDADRP NVIRISQSNQ HWMNKQYYLL AASSSEEADG
960 970 980 990 1000
WQNNLFELTR SVNTKMSILR TKEKEKRIAA ELSNLVVYCQ AVPFDPAHIY
1010 1020 1030 1040 1050
NDAFYEMCSF VEGKLDKLVE KGLLPFNSRK LSRVYPNGSR ITSNNYSPVP
1060 1070 1080 1090 1100
MWNAGCHMVA LNYQTGDKPM QLNQGKFLAN GRCGYLLKPD YMLTDDFDPT
1110 1120 1130 1140 1150
NTEKFATAYP IRLNVQVIGG RHLSRKDKNK GICSPFVEIE IIGMPCDTKV
1160 1170 1180 1190 1200
FQTKTIASNG LNPIWNQTFT FEIQCPEVAL IRFHVEDGDF VGPKTDPFIG
1210 1220 1230 1240 1250
QAVFPVDSIR CGFRSVPLKN QYSEELELSS LLVDVQMCSR EGTQLIRSSS
1260 1270 1280 1290 1300
HFLQASRLAP VFAHRKITNG DSIPREMAPR LRTSATDRSL DSPTNSESRA
1310 1320 1330 1340 1350
TLLSGQRGSQ DSMDSAAETS SIASGTISSR DGKKKQNWLK KFSFGKSSKS
Length:1,350
Mass (Da):154,574
Last modified:September 23, 2008 - v2
Checksum:i8F636BE56E7F58F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88745.2.
RefSeqiNP_496205.2. NM_063804.4.
UniGeneiCel.14497.

Genome annotation databases

EnsemblMetazoaiT01E8.3; T01E8.3; WBGene00004038.
GeneIDi174586.
KEGGicel:CELE_T01E8.3.
UCSCiT01E8.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA88745.2.
RefSeqiNP_496205.2. NM_063804.4.
UniGeneiCel.14497.

3D structure databases

ProteinModelPortaliQ22070.
SMRiQ22070. Positions 279-495, 600-897, 981-1237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ22070. 2 interactions.
STRINGi6239.T01E8.3.

Proteomic databases

EPDiQ22070.
PaxDbiQ22070.
PRIDEiQ22070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01E8.3; T01E8.3; WBGene00004038.
GeneIDi174586.
KEGGicel:CELE_T01E8.3.
UCSCiT01E8.3. c. elegans.

Organism-specific databases

CTDi174586.
WormBaseiT01E8.3; CE42905; WBGene00004038; plc-3.

Phylogenomic databases

eggNOGiKOG1264. Eukaryota.
ENOG410XPXE. LUCA.
GeneTreeiENSGT00730000110782.
HOGENOMiHOG000230864.
InParanoidiQ22070.
KOiK01116.
OMAiPANREEK.
OrthoDBiEOG091G07R3.
PhylomeDBiQ22070.

Enzyme and pathway databases

ReactomeiR-CEL-114604. GPVI-mediated activation cascade.
R-CEL-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-CEL-202433. Generation of second messenger molecules.
R-CEL-5607764. CLEC7A (Dectin-1) signaling.
SignaLinkiQ22070.

Gene expression databases

BgeeiWBGene00004038.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR016279. PLC-gamma.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 2 hits.
PfamiPF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000952. PLC-gamma. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
PR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 2 hits.
SSF51695. SSF51695. 2 hits.
SSF55550. SSF55550. 3 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ22070_CAEEL
AccessioniPrimary (citable) accession number: Q22070
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.