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Protein

Probable aspartate aminotransferase, cytoplasmic

Gene

got-1.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a key role in amino acid metabolism.By similarity

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Aspartate; via amide nitrogenBy similarity1
Binding sitei133AspartateBy similarity1
Binding sitei187AspartateBy similarity1
Binding sitei379AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-70263. Gluconeogenesis.
R-CEL-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aspartate aminotransferase, cytoplasmic (EC:2.6.1.1)
Alternative name(s):
Glutamate oxaloacetate transaminase 1.2
Transaminase A
Gene namesi
Name:got-1.2
ORF Names:T01C8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01C8.5; CE07462; WBGene00020146; got-1.2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238761 – 408Probable aspartate aminotransferase, cytoplasmicAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ22067.
PaxDbiQ22067.
PeptideAtlasiQ22067.
PRIDEiQ22067.

Expressioni

Gene expression databases

BgeeiWBGene00020146.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.T01C8.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ22067.
SMRiQ22067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
GeneTreeiENSGT00390000014081.
HOGENOMiHOG000185898.
InParanoidiQ22067.
KOiK14454.
OMAiQIADVCE.
OrthoDBiEOG091G06G3.
PhylomeDBiQ22067.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q22067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFDGIPVA PPIEVFHKNK MYLDETAPVK VNLTIGAYRT EEGQPWVLPV
60 70 80 90 100
VHETEVEIAN DTSLNHEYLP VLGHEGFRKA ATELVLGAES PAIKEERSFG
110 120 130 140 150
VQCLSGTGAL RAGAEFLASV CNMKTVYVSN PTWGNHKLVF KKAGFTTVAD
160 170 180 190 200
YTFWDYDNKR VHIEKFLSDL ESAPEKSVII LHGCAHNPTG MDPTQEQWKL
210 220 230 240 250
VAEVIKRKNL FTFFDIAYQG FASGDPAADA WAIRYFVDQG MEMVVSQSFA
260 270 280 290 300
KNFGLYNERV GNLTVVVNNP AVIAGFQSQM SLVIRANWSN PPAHGARIVH
310 320 330 340 350
KVLTTPARRE QWNQSIQAMS SRIKQMRAAL LRHLMDLGTP GTWDHIIQQI
360 370 380 390 400
GMFSYTGLTS AQVDHLIANH KVFLLRDGRI NICGLNTKNV EYVAKAIDET

VRAVKSNI
Length:408
Mass (Da):45,493
Last modified:November 1, 1997 - v1
Checksum:iA4DDCBCB8C0EFD83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081053 Genomic DNA. Translation: CCD68837.1.
PIRiT29857.
RefSeqiNP_510709.1. NM_078308.5.
UniGeneiCel.7966.

Genome annotation databases

EnsemblMetazoaiT01C8.5.1; T01C8.5.1; WBGene00020146.
T01C8.5.2; T01C8.5.2; WBGene00020146.
GeneIDi181726.
KEGGicel:CELE_T01C8.5.
UCSCiT01C8.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081053 Genomic DNA. Translation: CCD68837.1.
PIRiT29857.
RefSeqiNP_510709.1. NM_078308.5.
UniGeneiCel.7966.

3D structure databases

ProteinModelPortaliQ22067.
SMRiQ22067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01C8.5.1.

Proteomic databases

EPDiQ22067.
PaxDbiQ22067.
PeptideAtlasiQ22067.
PRIDEiQ22067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01C8.5.1; T01C8.5.1; WBGene00020146.
T01C8.5.2; T01C8.5.2; WBGene00020146.
GeneIDi181726.
KEGGicel:CELE_T01C8.5.
UCSCiT01C8.5. c. elegans.

Organism-specific databases

CTDi181726.
WormBaseiT01C8.5; CE07462; WBGene00020146; got-1.2.

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
GeneTreeiENSGT00390000014081.
HOGENOMiHOG000185898.
InParanoidiQ22067.
KOiK14454.
OMAiQIADVCE.
OrthoDBiEOG091G06G3.
PhylomeDBiQ22067.

Enzyme and pathway databases

ReactomeiR-CEL-70263. Gluconeogenesis.
R-CEL-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

PROiQ22067.

Gene expression databases

BgeeiWBGene00020146.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAATC_CAEEL
AccessioniPrimary (citable) accession number: Q22067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.