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Protein

Probable aspartate aminotransferase, cytoplasmic

Gene

got-1.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a key role in amino acid metabolism.By similarity

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Aspartate; via amide nitrogenBy similarity1
Binding sitei133AspartateBy similarity1
Binding sitei187AspartateBy similarity1
Binding sitei379AspartateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-70263 Gluconeogenesis
R-CEL-70614 Amino acid synthesis and interconversion (transamination)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aspartate aminotransferase, cytoplasmic (EC:2.6.1.1)
Alternative name(s):
Glutamate oxaloacetate transaminase 1.2
Transaminase A
Gene namesi
Name:got-1.2
ORF Names:T01C8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01C8.5 ; CE07462 ; WBGene00020146 ; got-1.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238761 – 408Probable aspartate aminotransferase, cytoplasmicAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ22067
PaxDbiQ22067
PeptideAtlasiQ22067
PRIDEiQ22067

Expressioni

Gene expression databases

BgeeiWBGene00020146

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.T01C8.5.1

Structurei

3D structure databases

ProteinModelPortaliQ22067
SMRiQ22067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
GeneTreeiENSGT00390000014081
HOGENOMiHOG000185898
InParanoidiQ22067
KOiK14454
OMAiELFKEWT
OrthoDBiEOG091G06G3
PhylomeDBiQ22067

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q22067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFDGIPVA PPIEVFHKNK MYLDETAPVK VNLTIGAYRT EEGQPWVLPV
60 70 80 90 100
VHETEVEIAN DTSLNHEYLP VLGHEGFRKA ATELVLGAES PAIKEERSFG
110 120 130 140 150
VQCLSGTGAL RAGAEFLASV CNMKTVYVSN PTWGNHKLVF KKAGFTTVAD
160 170 180 190 200
YTFWDYDNKR VHIEKFLSDL ESAPEKSVII LHGCAHNPTG MDPTQEQWKL
210 220 230 240 250
VAEVIKRKNL FTFFDIAYQG FASGDPAADA WAIRYFVDQG MEMVVSQSFA
260 270 280 290 300
KNFGLYNERV GNLTVVVNNP AVIAGFQSQM SLVIRANWSN PPAHGARIVH
310 320 330 340 350
KVLTTPARRE QWNQSIQAMS SRIKQMRAAL LRHLMDLGTP GTWDHIIQQI
360 370 380 390 400
GMFSYTGLTS AQVDHLIANH KVFLLRDGRI NICGLNTKNV EYVAKAIDET

VRAVKSNI
Length:408
Mass (Da):45,493
Last modified:November 1, 1997 - v1
Checksum:iA4DDCBCB8C0EFD83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081053 Genomic DNA Translation: CCD68837.1
PIRiT29857
RefSeqiNP_510709.1, NM_078308.5
UniGeneiCel.7966

Genome annotation databases

EnsemblMetazoaiT01C8.5.1; T01C8.5.1; WBGene00020146
T01C8.5.2; T01C8.5.2; WBGene00020146
GeneIDi181726
KEGGicel:CELE_T01C8.5
UCSCiT01C8.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiAATC_CAEEL
AccessioniPrimary (citable) accession number: Q22067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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