Reviewed, UniProtKB/Swiss-Prot Q22067 (AATC_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable aspartate aminotransferase, cytoplasmic
    EC=2.6.1.1
Alternative name(s):
    Transaminase A
    Glutamate oxaloacetate transaminase 1

Gene names

ORF Names:

T01C8.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential.
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Probable aspartate aminotransferase, cytoplasmic		PRO_0000123876
Amino acid modifications
	Modified residue	251	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q22067-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: A4DDCBCB8C0EFD83	FASTA	408	45,493
	10 20 30 40 50 60 MSFFDGIPVA PPIEVFHKNK MYLDETAPVK VNLTIGAYRT EEGQPWVLPV VHETEVEIAN 70 80 90 100 110 120 DTSLNHEYLP VLGHEGFRKA ATELVLGAES PAIKEERSFG VQCLSGTGAL RAGAEFLASV 130 140 150 160 170 180 CNMKTVYVSN PTWGNHKLVF KKAGFTTVAD YTFWDYDNKR VHIEKFLSDL ESAPEKSVII 190 200 210 220 230 240 LHGCAHNPTG MDPTQEQWKL VAEVIKRKNL FTFFDIAYQG FASGDPAADA WAIRYFVDQG 250 260 270 280 290 300 MEMVVSQSFA KNFGLYNERV GNLTVVVNNP AVIAGFQSQM SLVIRANWSN PPAHGARIVH 310 320 330 340 350 360 KVLTTPARRE QWNQSIQAMS SRIKQMRAAL LRHLMDLGTP GTWDHIIQQI GMFSYTGLTS 370 380 390 400 AQVDHLIANH KVFLLRDGRI NICGLNTKNV EYVAKAIDET VRAVKSNI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U58726 Genomic DNA. Translation: AAB00578.1.
PIR	T29857.
RefSeq	NP_510709.1.
UniGene	Cel.7966
3D structure databases
HSSP	HSSP built from PDB template 1AJS based on UniProtKB P00503.
ModBase	Search...
Protein-protein interaction databases
STRING	Q22067.
Genome annotation databases
Ensembl	T01C8.5; T01C8.5; T01C8.5; Caenorhabditis elegans. [Genome view]
GeneID	181726.
KEGG	cel:T01C8.5.
UCSC	T01C8.5. c. elegans.
Organism-specific databases
CTD	181726.
WormBase	WBGene00020146. T01C8.5.
WormPep	T01C8.5. CE07462. [WorfDB]
Phylogenomic databases
OMA	ASVMKRR.
Enzyme and pathway databases
BRENDA	2.6.1.1. 672.
Gene expression databases
ArrayExpress	Q22067.
Family and domain databases
InterPro	IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11879. Asp_trans. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	915102.

Entry information

Entry name

AATC_CAEEL

Accession

Primary (citable) accession number: Q22067

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project