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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-21

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-21Imported
ORF Names:CELE_T01B4.1Imported, T01B4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT01B4.1; CE43241; WBGene00006674; twk-21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei131 – 15222HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24220HelicalSequence analysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35220HelicalSequence analysisAdd
BLAST
Transmembranei358 – 37720HelicalSequence analysisAdd
BLAST
Transmembranei384 – 40522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ22042.

Interactioni

Protein-protein interaction databases

STRINGi6239.T01B4.1.

Structurei

3D structure databases

ProteinModelPortaliQ22042.
SMRiQ22042. Positions 144-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 27570Ion_trans_2InterPro annotationAdd
BLAST
Domaini337 – 41074Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000000700.
InParanoidiQ22042.
KOiK05323.
OrthoDBiEOG744T8R.
PhylomeDBiQ22042.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

Q22042-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQKDSIRRQ RSNLNEEQTN EARKILSKYV RQRRKYGKNN VAEANKENAN
60 70 80 90 100
IEQLHTPDTE SESQFLRPVK RRSNSFNSTP STPDDYESFF SPEFSQDPEE
110 120 130 140 150
INIKKDLRQR SQETWGQWFV RVVETLSELL GIRYIMLILI ILGYACLGGY
160 170 180 190 200
MFQALEYDQQ QLELEAEKRV RLSESSLLAV NLLEHLKQMN CGQSNEKRCL
210 220 230 240 250
ELITKTFIQR SDEERGEGWR WDFWNSVFFS ATIFTTIGYG NLACKTNLGR
260 270 280 290 300
IATIIYGMIG IPLMLFVLKN FGELCVKWAK KIQFNVQQCL KKCFGRKQKR
310 320 330 340 350
ASSLASITSK EMLEVFFEVP EDDKEDTTFQ LRWGLLVIVL FVVLCSFVVS
360 370 380 390 400
FWENWDFLTA FYFFFVSLST IGFGDIVPDH PRTACALFVL YFIGLALFAM
410 420 430 440 450
VYAILQERVE NQYMWALELI DQKYQEKLKQ DMYDEDEKKA DKNDMHFSKK
460 470 480 490 500
EPVRGPRILL QDLLRGPDLK ISGGRRSSSD ASSVITEASD EDTRHFKVGR
510 520 530 540 550
AILAEAFAPD ERASNHGSDE SLEEHQLETY DTSGTPPPYG DPTPTTNFQT
560 570 580
RDETVTSLAE KTPLSLNKVL EEENEDENGD S
Length:581
Mass (Da):67,124
Last modified:December 16, 2008 - v2
Checksum:iBFA0B97BD62D00D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA93875.2.
RefSeqiNP_510654.2. NM_078253.2.
UniGeneiCel.28875.

Genome annotation databases

EnsemblMetazoaiT01B4.1; T01B4.1; WBGene00006674.
GeneIDi192078.
KEGGicel:CELE_T01B4.1.
UCSCiT01B4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA93875.2.
RefSeqiNP_510654.2. NM_078253.2.
UniGeneiCel.28875.

3D structure databases

ProteinModelPortaliQ22042.
SMRiQ22042. Positions 144-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01B4.1.

Proteomic databases

PaxDbiQ22042.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01B4.1; T01B4.1; WBGene00006674.
GeneIDi192078.
KEGGicel:CELE_T01B4.1.
UCSCiT01B4.1. c. elegans.

Organism-specific databases

CTDi192078.
WormBaseiT01B4.1; CE43241; WBGene00006674; twk-21.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000000700.
InParanoidiQ22042.
KOiK05323.
OrthoDBiEOG744T8R.
PhylomeDBiQ22042.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ22042_CAEEL
AccessioniPrimary (citable) accession number: Q22042
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: December 16, 2008
Last modified: June 8, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.