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Q22017 (FLAD1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable FAD synthase

EC=2.7.7.2
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Including the following 2 domains:

  1. Molybdenum cofactor biosynthesis protein-like region
  2. FAD synthase region
Gene names
ORF Names:R53.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme By similarity.

Catalytic activity

ATP + FMN = diphosphate + FAD.

Cofactor

Magnesium By similarity.

Pathway

Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.

Domain

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similarities

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q22017-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: Q22017-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 519519Probable FAD synthase
PRO_0000302743

Regions

Region17 – 10892Molybdenum cofactor biosynthesis protein-like
Region328 – 485158FAD synthase

Natural variations

Alternative sequence1 – 99Missing in isoform b.
VSP_027956

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8B53D20915C85B59

FASTA51958,965
        10         20         30         40         50         60 
MRAMFRTPRM PQRKTAAILV IGDEILKGTT RDTNSHFLCK RLHKLGVNIR KISVIGDDIS 

        70         80         90        100        110        120 
EISREVQSAS GAYDYVITSG GVGPTHDDKT YLGLAHAFTD QMQFSDEIRQ AVNRFLPTYT 

       130        140        150        160        170        180 
AKKRAEGVGE GLEEAVRLAT EKLCTIPKMS QLLWGTQKIN GSLSTFPVVR ISNVVALPGV 

       190        200        210        220        230        240 
PKFCERAFDE LQDQLFPIEE RQSLCFETLY TDLDEFDFSK KLTDLAAQFE DRNVQIGSYP 

       250        260        270        280        290        300 
ELKNKFFKTK LTIETESSET MEAVVTSLRE LLAGHIVYYD SHAWLDIVTK WKAFKKRKAS 

       310        320        330        340        350        360 
ENQIEFIQKL NEAESIVEEI VEKYPLEQIA LSFNGGKDCT VLLHLLRLKV DEKYGPSTPI 

       370        380        390        400        410        420 
QGFHIMVEDQ FPEATQFIID AAKFYNIQVL EFPGPLKTGL AALKKTRPSI IPVLMGSRAT 

       430        440        450        460        470        480 
DPNGKYMKTP VEWTDSDWPQ VLRVCPILNW TYTDVWHMLR GLCVPYCKLY DQGYTSLGGR 

       490        500        510 
DNTVKHPALR IVSSDGREHY LPAYKLHNDA EERCNRSNI 

« Hide

Isoform b [UniParc].

Checksum: 907047BF3727BBAC
Show »

FASTA51057,817

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z66515 Genomic DNA. Translation: CAA91346.1.
Z66515 Genomic DNA. Translation: CAI70410.1.
PIRT24243.
RefSeqNP_001022286.1. NM_001027115.2.
NP_001022287.1. NM_001027116.3.
UniGeneCel.30862.

3D structure databases

ProteinModelPortalQ22017.
SMRQ22017. Positions 14-195, 304-518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.R53.1a.1.

Proteomic databases

PaxDbQ22017.
PRIDEQ22017.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR53.1a; R53.1a; R53.1. [Q22017-1]
GeneID3565030.
KEGGcel:CELE_R53.1.
UCSCR53.1a.1. c. elegans. [Q22017-1]

Organism-specific databases

CTD3565030.
WormBaseR53.1a; CE02303; WBGene00011271.
R53.1b; CE38215; WBGene00011271.

Phylogenomic databases

eggNOGCOG0175.
HOGENOMHOG000007185.
InParanoidQ22017.
KOK00953.
OMASFMRINP.
PhylomeDBQ22017.

Enzyme and pathway databases

UniPathwayUPA00277; UER00407.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 1 hit.
[Graphical view]
PIRSFPIRSF036620. MPTbdFAD. 1 hit.
SMARTSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF53218. SSF53218. 1 hit.
ProtoNetSearch...

Other

NextBio954909.
PROQ22017.

Entry information

Entry nameFLAD1_CAEEL
AccessionPrimary (citable) accession number: Q22017
Secondary accession number(s): Q58AA6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase