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Q22017

- FLAD1_CAEEL

UniProt

Q22017 - FLAD1_CAEEL

Protein

Probable FAD synthase

Gene

R53.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.By similarity

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FMN adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-UniPathway
    2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable FAD synthase (EC:2.7.7.2)
    Alternative name(s):
    FAD pyrophosphorylase
    FMN adenylyltransferase
    Flavin adenine dinucleotide synthase
    Including the following 2 domains:
    Molybdenum cofactor biosynthesis protein-like region
    FAD synthase region
    Gene namesi
    ORF Names:R53.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiR53.1a; CE02303; WBGene00011271.
    R53.1b; CE38215; WBGene00011271.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Probable FAD synthasePRO_0000302743Add
    BLAST

    Proteomic databases

    PaxDbiQ22017.
    PRIDEiQ22017.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.R53.1a.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ22017.
    SMRiQ22017. Positions 14-195, 308-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 10892Molybdenum cofactor biosynthesis protein-likeAdd
    BLAST
    Regioni328 – 485158FAD synthaseAdd
    BLAST

    Domaini

    The molybdenum cofactor biosynthesis protein-like region may not be functional.

    Sequence similaritiesi

    In the N-terminal section; belongs to the MoaB/Mog family.Curated
    In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0175.
    GeneTreeiENSGT00390000007266.
    HOGENOMiHOG000007185.
    InParanoidiQ22017.
    KOiK00953.
    OMAiSFMRINP.
    PhylomeDBiQ22017.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProiIPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
    SMARTiSM00852. MoCF_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53218. SSF53218. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q22017-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRAMFRTPRM PQRKTAAILV IGDEILKGTT RDTNSHFLCK RLHKLGVNIR    50
    KISVIGDDIS EISREVQSAS GAYDYVITSG GVGPTHDDKT YLGLAHAFTD 100
    QMQFSDEIRQ AVNRFLPTYT AKKRAEGVGE GLEEAVRLAT EKLCTIPKMS 150
    QLLWGTQKIN GSLSTFPVVR ISNVVALPGV PKFCERAFDE LQDQLFPIEE 200
    RQSLCFETLY TDLDEFDFSK KLTDLAAQFE DRNVQIGSYP ELKNKFFKTK 250
    LTIETESSET MEAVVTSLRE LLAGHIVYYD SHAWLDIVTK WKAFKKRKAS 300
    ENQIEFIQKL NEAESIVEEI VEKYPLEQIA LSFNGGKDCT VLLHLLRLKV 350
    DEKYGPSTPI QGFHIMVEDQ FPEATQFIID AAKFYNIQVL EFPGPLKTGL 400
    AALKKTRPSI IPVLMGSRAT DPNGKYMKTP VEWTDSDWPQ VLRVCPILNW 450
    TYTDVWHMLR GLCVPYCKLY DQGYTSLGGR DNTVKHPALR IVSSDGREHY 500
    LPAYKLHNDA EERCNRSNI 519
    Length:519
    Mass (Da):58,965
    Last modified:November 1, 1996 - v1
    Checksum:i8B53D20915C85B59
    GO
    Isoform b (identifier: Q22017-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:510
    Mass (Da):57,817
    Checksum:i907047BF3727BBAC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform b. CuratedVSP_027956

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66515 Genomic DNA. Translation: CAA91346.1.
    Z66515 Genomic DNA. Translation: CAI70410.1.
    PIRiT24243.
    RefSeqiNP_001022286.1. NM_001027115.2. [Q22017-1]
    NP_001022287.1. NM_001027116.3. [Q22017-2]
    UniGeneiCel.30862.

    Genome annotation databases

    EnsemblMetazoaiR53.1a.1; R53.1a.1; WBGene00011271. [Q22017-1]
    R53.1a.2; R53.1a.2; WBGene00011271. [Q22017-1]
    GeneIDi3565030.
    KEGGicel:CELE_R53.1.
    UCSCiR53.1a.1. c. elegans. [Q22017-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z66515 Genomic DNA. Translation: CAA91346.1 .
    Z66515 Genomic DNA. Translation: CAI70410.1 .
    PIRi T24243.
    RefSeqi NP_001022286.1. NM_001027115.2. [Q22017-1 ]
    NP_001022287.1. NM_001027116.3. [Q22017-2 ]
    UniGenei Cel.30862.

    3D structure databases

    ProteinModelPortali Q22017.
    SMRi Q22017. Positions 14-195, 308-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.R53.1a.1.

    Proteomic databases

    PaxDbi Q22017.
    PRIDEi Q22017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R53.1a.1 ; R53.1a.1 ; WBGene00011271 . [Q22017-1 ]
    R53.1a.2 ; R53.1a.2 ; WBGene00011271 . [Q22017-1 ]
    GeneIDi 3565030.
    KEGGi cel:CELE_R53.1.
    UCSCi R53.1a.1. c. elegans. [Q22017-1 ]

    Organism-specific databases

    CTDi 3565030.
    WormBasei R53.1a ; CE02303 ; WBGene00011271 .
    R53.1b ; CE38215 ; WBGene00011271 .

    Phylogenomic databases

    eggNOGi COG0175.
    GeneTreei ENSGT00390000007266.
    HOGENOMi HOG000007185.
    InParanoidi Q22017.
    KOi K00953.
    OMAi SFMRINP.
    PhylomeDBi Q22017.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .

    Miscellaneous databases

    NextBioi 954909.
    PROi Q22017.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProi IPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
    SMARTi SM00852. MoCF_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53218. SSF53218. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiFLAD1_CAEEL
    AccessioniPrimary (citable) accession number: Q22017
    Secondary accession number(s): Q58AA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3