ID   PDE4_CAEEL              Reviewed;         674 AA.
AC   Q22000; Q86NE7; Q86NE8; Q86NE9; Q8IFZ3; Q95ZQ6;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Probable 3',5'-cyclic phosphodiesterase pde-4;
DE            EC=3.1.4.17;
GN   Name=pde-4; ORFNames=R153.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
RP   SPLICING.
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O =
CC       nucleoside 5'-phosphate.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=d;
CC         IsoId=Q22000-1; Sequence=Displayed;
CC         Note=No experimental confirmation available;
CC       Name=a;
CC         IsoId=Q22000-2; Sequence=VSP_014345, VSP_014352;
CC         Note=No experimental confirmation available;
CC       Name=b;
CC         IsoId=Q22000-3; Sequence=VSP_014347, VSP_014350;
CC         Note=No experimental confirmation available;
CC       Name=c;
CC         IsoId=Q22000-4; Sequence=VSP_014346, VSP_014351;
CC         Note=No experimental confirmation available;
CC       Name=e;
CC         IsoId=Q22000-5; Sequence=VSP_014348, VSP_014349;
CC         Note=No experimental confirmation available;
CC       Name=f;
CC         IsoId=Q22000-6; Sequence=VSP_014353, VSP_014354;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family.
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DR   EMBL; U28729; AAA68292.1; -; Genomic_DNA.
DR   EMBL; U28729; AAK77625.1; -; Genomic_DNA.
DR   EMBL; U28729; AAN60496.1; -; Genomic_DNA.
DR   EMBL; U28729; AAO38607.1; -; Genomic_DNA.
DR   EMBL; U28729; AAO38608.1; -; Genomic_DNA.
DR   EMBL; U28729; AAO38609.1; -; Genomic_DNA.
DR   PIR; T16769; T16769.
DR   RefSeq; NP_871945.1; -.
DR   UniGene; Cel.17824; -.
DR   HSSP; Q08499; 1OYN.
DR   Ensembl; R153.1; Caenorhabditis elegans.
DR   GeneID; 174235; -.
DR   WormBase; WBGene00020114; pde-4.
DR   WormPep; R153.1a; CE02038.
DR   WormPep; R153.1b; CE28641.
DR   WormPep; R153.1c; CE32060.
DR   WormPep; R153.1d; CE33438.
DR   WormPep; R153.1e; CE33439.
DR   WormPep; R153.1f; CE33440.
DR   OMA; Q22000; HEENCDI.
DR   BRENDA; 3.1.4.17; 672.
DR   NextBio; 883133; -.
DR   ArrayExpress; Q22000; -.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase a...; IEA:EC.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR003607; Met-dep_phosphohydro_HD.
DR   InterPro; IPR002073; PDEase.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; cAMP; Complete proteome; Hydrolase.
FT   CHAIN         1    674       Probable 3',5'-cyclic phosphodiesterase
FT                                pde-4.
FT                                /FTId=PRO_0000198847.
FT   VAR_SEQ       1    125       Missing (in isoform a).
FT                                /FTId=VSP_014345.
FT   VAR_SEQ       1     75       Missing (in isoform c).
FT                                /FTId=VSP_014346.
FT   VAR_SEQ       1     62       Missing (in isoform b).
FT                                /FTId=VSP_014347.
FT   VAR_SEQ       1     48       Missing (in isoform e).
FT                                /FTId=VSP_014348.
FT   VAR_SEQ      49     91       SRTPPAALPPRTSAVTIPGSNHKLTSSASSYHPPRELTVST
FT                                FS -> MCGSRRHLRRNEDGMNGVARRKQFKLRPWQSTALP
FT                                SRHDHYSC (in isoform e).
FT                                /FTId=VSP_014349.
FT   VAR_SEQ      63     91       VTIPGSNHKLTSSASSYHPPRELTVSTFS -> MNGVARRK
FT                                QFKLRPWQSTALPSRHDHYSC (in isoform b).
FT                                /FTId=VSP_014350.
FT   VAR_SEQ      76     90       ASSYHPPRELTVSTF -> MTSRRHTVWFVPGSR (in
FT                                isoform c).
FT                                /FTId=VSP_014351.
FT   VAR_SEQ     126    150       SDDLREASSLRPVSRASSIASNEHG -> MSISLINNNNRS
FT                                VRRKFGESGFTLR (in isoform a).
FT                                /FTId=VSP_014352.
FT   VAR_SEQ     151    158       HGDDLIVT -> YVILYIFL (in isoform f).
FT                                /FTId=VSP_014353.
FT   VAR_SEQ     159    674       Missing (in isoform f).
FT                                /FTId=VSP_014354.
SQ   SEQUENCE   674 AA;  75389 MW;  87BA310BE45DBD30 CRC64;
     MPRRRGSSSS SSAAGGSGGG GGFGFSSLRR ELHLHNFFRT SSPSASSTSR TPPAALPPRT
     SAVTIPGSNH KLTSSASSYH PPRELTVSTF SAGSATAADG LGGAHLTPSL SSSVHARRES
     FLYRASDDLR EASSLRPVSR ASSIASNEHG HGDDLIVTPF AQLLASLRNV RSNLISITNI
     QNSDDSRHAN RSAKRPPLHN IELPDDVVHC AHDTLEELDW CLDQLETIQT HRSVSEMASS
     KFRKMLNKEL SHFAESSKSG TQVSKFLITT YMDKEEDEPS IEIEVPTEVQ GPSTSGPMTL
     SILKKAQTAA MNKISGVRKL RAPSHDGHVP EYGVNCAREI AVHMQRLDDW GPDVFKIDEL
     SKNHSLTVVT FSLLRQRNLF KTFEIHQSTL VTYLLNLEHH YRNNHYHNFI HAADVAQSMH
     VLLMSPVLTE VFTDLEVLAA IFAGAVHDVD HPGFTNQYLI NSNNELAIMY NDESVLEQHH
     LAVAFKLLQD SNCDFLANLS RKQRLQFRKI VIDMVLATDM SKHMSLLADL KTMVEAKKVA
     GNNVIVLDKY NDKIQVLQSM IHLADLSNPT KPIELYQQWN QRIMEEYWRQ GDKEKELGLE
     ISPMCDRGNV TIEKSQVGFI DYIVHPLYET WADLVYPDAQ NILDQLEENR EWYQSRIPEE
     PDTARTVTED DEHK
//