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Protein

Probable 3',5'-cyclic phosphodiesterase pde-4

Gene

pde-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei407Proton donorBy similarity1
Metal bindingi411Divalent metal cation 1By similarity1
Metal bindingi447Divalent metal cation 1By similarity1
Metal bindingi448Divalent metal cation 1By similarity1
Metal bindingi448Divalent metal cation 2By similarity1
Metal bindingi565Divalent metal cation 1By similarity1

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  • cAMP catabolic process Source: WormBase
  • negative regulation of cAMP-mediated signaling Source: WormBase
  • negative regulation of locomotion Source: WormBase
  • sleep Source: WormBase

Keywordsi

Molecular functionHydrolase
LigandcAMP, Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-180024 DARPP-32 events
R-CEL-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3',5'-cyclic phosphodiesterase pde-4 (EC:3.1.4.17)
Gene namesi
Name:pde-4
ORF Names:R153.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiR153.1a ; CE02038 ; WBGene00020114 ; pde-4
R153.1b ; CE28641 ; WBGene00020114 ; pde-4
R153.1c ; CE32060 ; WBGene00020114 ; pde-4
R153.1d ; CE33438 ; WBGene00020114 ; pde-4
R153.1e ; CE33439 ; WBGene00020114 ; pde-4
R153.1f ; CE33440 ; WBGene00020114 ; pde-4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988471 – 674Probable 3',5'-cyclic phosphodiesterase pde-4Add BLAST674

Proteomic databases

PaxDbiQ22000
PeptideAtlasiQ22000
PRIDEiQ22000

Expressioni

Gene expression databases

BgeeiWBGene00020114
ExpressionAtlasiQ22000 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.R153.1d

Structurei

3D structure databases

ProteinModelPortaliQ22000
SMRiQ22000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini328 – 660PDEasePROSITE-ProRule annotationAdd BLAST333

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000236297
InParanoidiQ22000
OMAiTCFDVEN
OrthoDBiEOG091G06CD
PhylomeDBiQ22000

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform d (identifier: Q22000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRRRGSSSS SSAAGGSGGG GGFGFSSLRR ELHLHNFFRT SSPSASSTSR
60 70 80 90 100
TPPAALPPRT SAVTIPGSNH KLTSSASSYH PPRELTVSTF SAGSATAADG
110 120 130 140 150
LGGAHLTPSL SSSVHARRES FLYRASDDLR EASSLRPVSR ASSIASNEHG
160 170 180 190 200
HGDDLIVTPF AQLLASLRNV RSNLISITNI QNSDDSRHAN RSAKRPPLHN
210 220 230 240 250
IELPDDVVHC AHDTLEELDW CLDQLETIQT HRSVSEMASS KFRKMLNKEL
260 270 280 290 300
SHFAESSKSG TQVSKFLITT YMDKEEDEPS IEIEVPTEVQ GPSTSGPMTL
310 320 330 340 350
SILKKAQTAA MNKISGVRKL RAPSHDGHVP EYGVNCAREI AVHMQRLDDW
360 370 380 390 400
GPDVFKIDEL SKNHSLTVVT FSLLRQRNLF KTFEIHQSTL VTYLLNLEHH
410 420 430 440 450
YRNNHYHNFI HAADVAQSMH VLLMSPVLTE VFTDLEVLAA IFAGAVHDVD
460 470 480 490 500
HPGFTNQYLI NSNNELAIMY NDESVLEQHH LAVAFKLLQD SNCDFLANLS
510 520 530 540 550
RKQRLQFRKI VIDMVLATDM SKHMSLLADL KTMVEAKKVA GNNVIVLDKY
560 570 580 590 600
NDKIQVLQSM IHLADLSNPT KPIELYQQWN QRIMEEYWRQ GDKEKELGLE
610 620 630 640 650
ISPMCDRGNV TIEKSQVGFI DYIVHPLYET WADLVYPDAQ NILDQLEENR
660 670
EWYQSRIPEE PDTARTVTED DEHK
Note: No experimental confirmation available.
Length:674
Mass (Da):75,389
Last modified:July 5, 2005 - v2
Checksum:i87BA310BE45DBD30
GO
Isoform a (identifier: Q22000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-150: SDDLREASSLRPVSRASSIASNEHG → MSISLINNNNRSVRRKFGESGFTLR

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):62,904
Checksum:iDF2EE6F03925DE87
GO
Isoform b (identifier: Q22000-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-91: VTIPGSNHKLTSSASSYHPPRELTVSTFS → MNGVARRKQFKLRPWQSTALPSRHDHYSC

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):69,498
Checksum:i5E75F83B7D539255
GO
Isoform c (identifier: Q22000-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-90: ASSYHPPRELTVSTF → MTSRRHTVWFVPGSR

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):67,932
Checksum:i30F3EC75C7A51CA6
GO
Isoform e (identifier: Q22000-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-91: SRTPPAALPP...PRELTVSTFS → MCGSRRHLRR...LPSRHDHYSC

Note: No experimental confirmation available.
Show »
Length:626
Mass (Da):71,167
Checksum:i548A274EC8D470D6
GO
Isoform f (identifier: Q22000-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     151-158: HGDDLIVT → YVILYIFL
     159-674: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):16,407
Checksum:i119F39EF1F6BEC58
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0143451 – 125Missing in isoform a. CuratedAdd BLAST125
Alternative sequenceiVSP_0143461 – 75Missing in isoform c. CuratedAdd BLAST75
Alternative sequenceiVSP_0143471 – 62Missing in isoform b. CuratedAdd BLAST62
Alternative sequenceiVSP_0143481 – 48Missing in isoform e. CuratedAdd BLAST48
Alternative sequenceiVSP_01434949 – 91SRTPP…VSTFS → MCGSRRHLRRNEDGMNGVAR RKQFKLRPWQSTALPSRHDH YSC in isoform e. CuratedAdd BLAST43
Alternative sequenceiVSP_01435063 – 91VTIPG…VSTFS → MNGVARRKQFKLRPWQSTAL PSRHDHYSC in isoform b. CuratedAdd BLAST29
Alternative sequenceiVSP_01435176 – 90ASSYH…TVSTF → MTSRRHTVWFVPGSR in isoform c. CuratedAdd BLAST15
Alternative sequenceiVSP_014352126 – 150SDDLR…SNEHG → MSISLINNNNRSVRRKFGES GFTLR in isoform a. CuratedAdd BLAST25
Alternative sequenceiVSP_014353151 – 158HGDDLIVT → YVILYIFL in isoform f. Curated8
Alternative sequenceiVSP_014354159 – 674Missing in isoform f. CuratedAdd BLAST516

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081170 Genomic DNA Translation: CCD69643.1
FO081170 Genomic DNA Translation: CCD69647.1
FO081170 Genomic DNA Translation: CCD69649.1
FO081170 Genomic DNA Translation: CCD69644.1
FO081170 Genomic DNA Translation: CCD69648.1
FO081170 Genomic DNA Translation: CCD69645.1
PIRiT16769
RefSeqiNP_495600.1, NM_063199.3 [Q22000-5]
NP_495601.1, NM_063200.1 [Q22000-2]
NP_871944.1, NM_182144.3 [Q22000-4]
NP_871945.1, NM_182145.3 [Q22000-1]
NP_871946.1, NM_182146.3 [Q22000-3]
NP_871947.1, NM_182147.3 [Q22000-6]
UniGeneiCel.17824

Genome annotation databases

EnsemblMetazoaiR153.1d; R153.1d; WBGene00020114 [Q22000-1]
GeneIDi174235
UCSCiR153.1b c. elegans [Q22000-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPDE4_CAEEL
AccessioniPrimary (citable) accession number: Q22000
Secondary accession number(s): Q86NE7
, Q86NE8, Q86NE9, Q8IFZ3, Q95ZQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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