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Q22000 (PDE4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3',5'-cyclic phosphodiesterase pde-4

EC=3.1.4.17
Gene names
Name:pde-4
ORF Names:R153.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform d (identifier: Q22000-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: Q22000-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     126-150: SDDLREASSLRPVSRASSIASNEHG → MSISLINNNNRSVRRKFGESGFTLR
Note: No experimental confirmation available.
Isoform b (identifier: Q22000-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-91: VTIPGSNHKLTSSASSYHPPRELTVSTFS → MNGVARRKQFKLRPWQSTALPSRHDHYSC
Note: No experimental confirmation available.
Isoform c (identifier: Q22000-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-90: ASSYHPPRELTVSTF → MTSRRHTVWFVPGSR
Note: No experimental confirmation available.
Isoform e (identifier: Q22000-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-91: SRTPPAALPP...PRELTVSTFS → MCGSRRHLRR...LPSRHDHYSC
Note: No experimental confirmation available.
Isoform f (identifier: Q22000-6)

The sequence of this isoform differs from the canonical sequence as follows:
     151-158: HGDDLIVT → YVILYIFL
     159-674: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 674674Probable 3',5'-cyclic phosphodiesterase pde-4
PRO_0000198847

Sites

Active site4071Proton donor By similarity
Metal binding4111Divalent metal cation 1 By similarity
Metal binding4471Divalent metal cation 1 By similarity
Metal binding4481Divalent metal cation 1 By similarity
Metal binding4481Divalent metal cation 2 By similarity
Metal binding5651Divalent metal cation 1 By similarity

Natural variations

Alternative sequence1 – 125125Missing in isoform a.
VSP_014345
Alternative sequence1 – 7575Missing in isoform c.
VSP_014346
Alternative sequence1 – 6262Missing in isoform b.
VSP_014347
Alternative sequence1 – 4848Missing in isoform e.
VSP_014348
Alternative sequence49 – 9143SRTPP…VSTFS → MCGSRRHLRRNEDGMNGVAR RKQFKLRPWQSTALPSRHDH YSC in isoform e.
VSP_014349
Alternative sequence63 – 9129VTIPG…VSTFS → MNGVARRKQFKLRPWQSTAL PSRHDHYSC in isoform b.
VSP_014350
Alternative sequence76 – 9015ASSYH…TVSTF → MTSRRHTVWFVPGSR in isoform c.
VSP_014351
Alternative sequence126 – 15025SDDLR…SNEHG → MSISLINNNNRSVRRKFGES GFTLR in isoform a.
VSP_014352
Alternative sequence151 – 1588HGDDLIVT → YVILYIFL in isoform f.
VSP_014353
Alternative sequence159 – 674516Missing in isoform f.
VSP_014354

Sequences

Sequence LengthMass (Da)Tools
Isoform d [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 87BA310BE45DBD30

FASTA67475,389
        10         20         30         40         50         60 
MPRRRGSSSS SSAAGGSGGG GGFGFSSLRR ELHLHNFFRT SSPSASSTSR TPPAALPPRT 

        70         80         90        100        110        120 
SAVTIPGSNH KLTSSASSYH PPRELTVSTF SAGSATAADG LGGAHLTPSL SSSVHARRES 

       130        140        150        160        170        180 
FLYRASDDLR EASSLRPVSR ASSIASNEHG HGDDLIVTPF AQLLASLRNV RSNLISITNI 

       190        200        210        220        230        240 
QNSDDSRHAN RSAKRPPLHN IELPDDVVHC AHDTLEELDW CLDQLETIQT HRSVSEMASS 

       250        260        270        280        290        300 
KFRKMLNKEL SHFAESSKSG TQVSKFLITT YMDKEEDEPS IEIEVPTEVQ GPSTSGPMTL 

       310        320        330        340        350        360 
SILKKAQTAA MNKISGVRKL RAPSHDGHVP EYGVNCAREI AVHMQRLDDW GPDVFKIDEL 

       370        380        390        400        410        420 
SKNHSLTVVT FSLLRQRNLF KTFEIHQSTL VTYLLNLEHH YRNNHYHNFI HAADVAQSMH 

       430        440        450        460        470        480 
VLLMSPVLTE VFTDLEVLAA IFAGAVHDVD HPGFTNQYLI NSNNELAIMY NDESVLEQHH 

       490        500        510        520        530        540 
LAVAFKLLQD SNCDFLANLS RKQRLQFRKI VIDMVLATDM SKHMSLLADL KTMVEAKKVA 

       550        560        570        580        590        600 
GNNVIVLDKY NDKIQVLQSM IHLADLSNPT KPIELYQQWN QRIMEEYWRQ GDKEKELGLE 

       610        620        630        640        650        660 
ISPMCDRGNV TIEKSQVGFI DYIVHPLYET WADLVYPDAQ NILDQLEENR EWYQSRIPEE 

       670 
PDTARTVTED DEHK 

« Hide

Isoform a [UniParc].

Checksum: DF2EE6F03925DE87
Show »

FASTA54962,904
Isoform b [UniParc].

Checksum: 5E75F83B7D539255
Show »

FASTA61269,498
Isoform c [UniParc].

Checksum: 30F3EC75C7A51CA6
Show »

FASTA59967,932
Isoform e [UniParc].

Checksum: 548A274EC8D470D6
Show »

FASTA62671,167
Isoform f [UniParc].

Checksum: 119F39EF1F6BEC58
Show »

FASTA15816,407

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081170 Genomic DNA. Translation: CCD69643.1.
FO081170 Genomic DNA. Translation: CCD69647.1.
FO081170 Genomic DNA. Translation: CCD69649.1.
FO081170 Genomic DNA. Translation: CCD69644.1.
FO081170 Genomic DNA. Translation: CCD69648.1.
FO081170 Genomic DNA. Translation: CCD69645.1.
PIRT16769.
RefSeqNP_495600.1. NM_063199.3. [Q22000-5]
NP_495601.1. NM_063200.1. [Q22000-2]
NP_871944.1. NM_182144.3. [Q22000-4]
NP_871945.1. NM_182145.3. [Q22000-1]
NP_871946.1. NM_182146.3. [Q22000-3]
NP_871947.1. NM_182147.3. [Q22000-6]
UniGeneCel.17824.

3D structure databases

ProteinModelPortalQ22000.
SMRQ22000. Positions 340-658.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.R153.1d.

Proteomic databases

PaxDbQ22000.
PRIDEQ22000.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR153.1d; R153.1d; WBGene00020114. [Q22000-1]
GeneID174235.
KEGGcel:CELE_R153.1.
UCSCR153.1b. c. elegans. [Q22000-1]

Organism-specific databases

CTD174235.
WormBaseR153.1a; CE02038; WBGene00020114; pde-4.
R153.1b; CE28641; WBGene00020114; pde-4.
R153.1c; CE32060; WBGene00020114; pde-4.
R153.1d; CE33438; WBGene00020114; pde-4.
R153.1e; CE33439; WBGene00020114; pde-4.
R153.1f; CE33440; WBGene00020114; pde-4.

Phylogenomic databases

eggNOGNOG122287.
GeneTreeENSGT00660000095451.
HOGENOMHOG000236297.
InParanoidQ22000.
KOK01120.
OMAKASHINN.
PhylomeDBQ22000.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883133.
PROQ22000.

Entry information

Entry namePDE4_CAEEL
AccessionPrimary (citable) accession number: Q22000
Secondary accession number(s): Q86NE7 expand/collapse secondary AC list , Q86NE8, Q86NE9, Q8IFZ3, Q95ZQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 5, 2005
Last modified: June 11, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase