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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166UniRule annotation1
Active sitei192UniRule annotation1
Active sitei288UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:Rfer_0906
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi
  • UP000008332 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643051 – 345Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei504-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_0906.

Structurei

3D structure databases

ProteinModelPortaliQ21ZZ9.
SMRiQ21ZZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST116
Domaini154 – 345CheB-type methylesteraseUniRule annotationAdd BLAST192

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21ZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVDDSAVVR QVVAGLLADD PAIEVIAAVA DPILAIARMK VQWPDVFVLD
60 70 80 90 100
IEMPRMDGIT FLKKIMAERP TPVVICSTLT EKGAQTSMAA LSAGAVAIIT
110 120 130 140 150
KPKLGLKQFL VDASDDLISA VKAAARANVK RLQVVEKLTA DAILPASDRH
160 170 180 190 200
DAMLQTTERV VALGTSTGGT QALEVVLTAL PRVTPGIVIV QHMPEKFTAE
210 220 230 240 250
FANRLNGLCQ ITVREAKNND RVVPGRALIA PGGKHMLLRR NGAQYSVEVL
260 270 280 290 300
DGPLVNRHRP SVDVLFRSVA RCAGANALGV IMTGMGDDGA AGLAEMRKAG
310 320 330 340
ARTLAQDEES CVVYGMPKEA VKRGGVERSV PLGAIAREIM AQMAG
Length:345
Mass (Da):36,509
Last modified:December 12, 2006 - v2
Checksum:i9591C597A522C40A
GO

Sequence cautioni

The sequence ABD68654 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA. Translation: ABD68654.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABD68654; ABD68654; Rfer_0906.
KEGGirfr:Rfer_0906.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_RHOFT
AccessioniPrimary (citable) accession number: Q21ZZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 22, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome