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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Rfer_1369
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi
  • UP000008332 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002436111 – 436Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ21YQ0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi338969.Rfer_1369

Structurei

3D structure databases

ProteinModelPortaliQ21YQ0
SMRiQ21YQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit

Sequencei

Sequence statusi: Complete.

Q21YQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNTDNNQI LFERAKRVIP GGVNSPVRAF KAVGGTPRFV KRAQGAYFWD
60 70 80 90 100
ANNQRYTDFI GSWGPMILGH GHPAVVEAVQ AAVLEGFSYG APTEREVELA
110 120 130 140 150
EEILRLVPSM DMVRLVSSGT EAAMSTIRLA RGATGRSKLI KFEGCYHGHA
160 170 180 190 200
DALLVKAGSG LATFGNPTSA GVPPEVVQHT VVLEYNNIEQ LEEAFAMQGS
210 220 230 240 250
EIACLMMEPI CGNMNFVRAS VPFVKRCREL CTQYGALLVF DEVMTGFRVA
260 270 280 290 300
LGGAQSVYAK EIPGFEPDMT VMGKVIGGGM PLAAFGAKRA VMEHLAPLGT
310 320 330 340 350
VYQAGTLSGN PVATACGLAT LREISKPGFY ESLARTTRSL TDGLKAAATA
360 370 380 390 400
EGLAFSADSE GGMFGFFLLD TLPQNYVQVM KSDSARFNQL FHGLLDRGVY
410 420 430
IAPALYEAGF VSAAHTAEDI AATVAAARAV FKIISK
Length:436
Mass (Da):46,526
Last modified:April 18, 2006 - v1
Checksum:i4DDA797921286793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA Translation: ABD69103.1
RefSeqiWP_011463671.1, NC_007908.1

Genome annotation databases

EnsemblBacteriaiABD69103; ABD69103; Rfer_1369
KEGGirfr:Rfer_1369

Similar proteinsi

Entry informationi

Entry nameiGSA_RHOFT
AccessioniPrimary (citable) accession number: Q21YQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 18, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health