Q21YM7 (F16A1_RHOFD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1 1
Short name=FBPase class 1 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 1

Gene names

Name:	fbp1
Ordered Locus Names:	Rfer_1393

Organism

Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) [Complete proteome] [HAMAP]

Taxonomic identifier

338969 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Albidiferax

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Fructose-1,6-bisphosphatase class 1 1 HAMAP MF_01855		PRO_0000364672
Regions
	Region	124 – 127	4	Substrate binding By similarity
Sites
	Metal binding	99	1	Magnesium 1 By similarity
	Metal binding	121	1	Magnesium 1 By similarity
	Metal binding	121	1	Magnesium 2 By similarity
	Metal binding	123	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	124	1	Magnesium 2 By similarity
	Metal binding	292	1	Magnesium 2 By similarity
	Binding site	220	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21YM7 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: CB6601897B068EE7	FASTA	364	40,103
	10 20 30 40 50 60 MPLTYRSTLT QFLIEERRRF PNASGDFNAL ILDVALACRA IARAVALGEL GGAMGNHAAE 70 80 90 100 110 120 TGGSVNVQGE TQKKLDVLSN EVFIRRTEWA GNLAGMASEE MELPYQIPQQ YPRGKYMLVF 130 140 150 160 170 180 DPLDGSSNID VNVCVGSIFS VLRAPQDALD SGRDLNEADF LQAGRQQVAA GYAVYGPSTL 190 200 210 220 230 240 LVLTVGNGVN GFTLDPNLGE FMLTHPKMQI PPETHEFAIN ASNSRFWQAP VKRYVDECLA 250 260 270 280 290 300 GQTGPRGKDF NMRWIASMVA EAHRILMRGG VFMYPRDNKD PAKPGRLRLL YEANPVGMLM 310 320 330 340 350 360 EQAGGRASTG ELPMLDVQPT SLHQRIGLVF GSKNEVERIE RYHAEPVQAE PSNPLFAERS LFRS

References

[1]

"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15236 / ATCC BAA-621 / T118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000267 Genomic DNA. Translation: ABD69126.1.
RefSeq	YP_522657.1. NC_007908.1.
3D structure databases
HSSP	HSSP built from PDB template 2F3B based on UniProtKB P00636.
ProteinModelPortal	Q21YM7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q21YM7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3962311.
GenomeReviews	Gene locus Rfer_1393 in contig CP000267_GR.
KEGG	rfr:Rfer_1393.
NMPDR	fig|338969.3.peg.3070.
PATRIC	23235353. VBIRhoFer131161_1698.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0158.
HOGENOM	HBG731261.
OMA	VMVYTTG.
PhylomeDB	Q21YM7.
ProtClustDB	CLSK923881.
Enzyme and pathway databases
BioCyc	RFER338969:RFER_1393-MONOMER.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16A1_RHOFD

Accession

Primary (citable) accession number: Q21YM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	April 18, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program