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Q21XX2

- NADK_ALBFT

UniProt

Q21XX2 - NADK_ALBFT

Protein

NAD kinase

Gene

nadK

Organism
Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei80 – 801Proton acceptorUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei184 – 1841NADUniRule annotation
    Binding sitei219 – 2191NAD; via carbonyl oxygenUniRule annotation
    Binding sitei253 – 2531NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 812NADUniRule annotation
    Nucleotide bindingi154 – 1552NADUniRule annotation
    Nucleotide bindingi195 – 2006NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAFER338969:GHU9-1668-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Rfer_1651
    OrganismiAlbidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
    Taxonomic identifieri338969 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
    ProteomesiUP000008332: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298NAD kinasePRO_1000005433Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi338969.Rfer_1651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ21XX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiHPSIPGW.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q21XX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSKFRHVAL IGKYQTVASG ASGASSRRVL EDIAHFLGAQ GCEVVFEHDT    50
    AHNMGISGYP VLDVDAIGAK CDLGLVVGGD GTMLGIGRQL AKFGVPLIGI 100
    NQGRLGFITD IPLDGYASAL APMLRGEFEE DHRSLMHARV MRDGRCVYDA 150
    LAMNDVVVNR AATSGMVELR VEVDGHFVAN QRADGLIIAT PTGSTAYSLS 200
    AGGPLLHPSI PGWVLVPIAP HTLSNRPIVL ANITEIAIEI ISGRDASASF 250
    DTQSLASLLR GDRIVVTRSE HNVRFLHPRG WSYFDTLRQK LHWNEGVA 298
    Length:298
    Mass (Da):32,015
    Last modified:April 18, 2006 - v1
    Checksum:i68FEDFC4E307DBC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000267 Genomic DNA. Translation: ABD69381.1.
    RefSeqiYP_522912.1. NC_007908.1.

    Genome annotation databases

    EnsemblBacteriaiABD69381; ABD69381; Rfer_1651.
    GeneIDi3962770.
    KEGGirfr:Rfer_1651.
    PATRICi23235911. VBIRhoFer131161_1967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000267 Genomic DNA. Translation: ABD69381.1 .
    RefSeqi YP_522912.1. NC_007908.1.

    3D structure databases

    ProteinModelPortali Q21XX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 338969.Rfer_1651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD69381 ; ABD69381 ; Rfer_1651 .
    GeneIDi 3962770.
    KEGGi rfr:Rfer_1651.
    PATRICi 23235911. VBIRhoFer131161_1967.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi HPSIPGW.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci AFER338969:GHU9-1668-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.
      , Kyrpides N., Ivanova N., Richardson P.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-621 / DSM 15236 / T118.

    Entry informationi

    Entry nameiNADK_ALBFT
    AccessioniPrimary (citable) accession number: Q21XX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3