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Q21XH1

- MDH1_ALBFT

UniProt

Q21XH1 - MDH1_ALBFT

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Protein

Malate dehydrogenase 1

Gene
mdh1, Rfer_1803
Organism
Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei101 – 1011Substrate By similarity
Binding sitei108 – 1081NAD By similarity
Binding sitei115 – 1151NAD By similarity
Binding sitei134 – 1341Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Active sitei190 – 1901Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NAD By similarity
Nucleotide bindingi132 – 1343NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAFER338969:GHU9-1822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 1 (EC:1.1.1.37)
Gene namesi
Name:mdh1
Ordered Locus Names:Rfer_1803
OrganismiAlbidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
ProteomesiUP000008332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 328327Malate dehydrogenase 1UniRule annotationPRO_0000294403Add
BLAST

Proteomic databases

PRIDEiQ21XH1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi338969.Rfer_1803.

Structurei

3D structure databases

ProteinModelPortaliQ21XH1.
SMRiQ21XH1. Positions 3-328.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFSQECI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q21XH1-1 [UniParc]FASTAAdd to Basket

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MSKKPVRVAV TGAAGQIGYA ILFRIASGEM LGKDQPVILQ LLEVPVEKAQ    50
QALQGVMMEL QDCAFPLLAG MEAHSDPMTA FKDVDYALLI GSRPRGPGME 100
RAELLAVNGA IFTAQGKALN AVASRNVKVL VVGNPANTNA YIAMKSAPDL 150
PAKNFTAMLR LDHNRALSQL ASKTGKAVAD IEKMAVWGNH SPTMYADYRF 200
ATINGESVKD MINDQDWNAN TFLPTVGKRG AAIIAARGVS SAASAANAAI 250
DHMRDWALGT NGKWVTMGIP SDGQYGIPKE TMFGFPVTCE GGEYKVVQNL 300
PIDAFSQECI NKTLKELQDE QAGVAHLL 328
Length:328
Mass (Da):35,077
Last modified:April 18, 2006 - v1
Checksum:i2462BA46D0A8F272
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD69532.1.
RefSeqiWP_011464100.1. NC_007908.1.
YP_523063.1. NC_007908.1.

Genome annotation databases

EnsemblBacteriaiABD69532; ABD69532; Rfer_1803.
GeneIDi3962200.
KEGGirfr:Rfer_1803.
PATRICi23236227. VBIRhoFer131161_2124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000267 Genomic DNA. Translation: ABD69532.1 .
RefSeqi WP_011464100.1. NC_007908.1.
YP_523063.1. NC_007908.1.

3D structure databases

ProteinModelPortali Q21XH1.
SMRi Q21XH1. Positions 3-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 338969.Rfer_1803.

Proteomic databases

PRIDEi Q21XH1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD69532 ; ABD69532 ; Rfer_1803 .
GeneIDi 3962200.
KEGGi rfr:Rfer_1803.
PATRICi 23236227. VBIRhoFer131161_2124.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi AFSQECI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci AFER338969:GHU9-1822-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M.
    , Kyrpides N., Ivanova N., Richardson P.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-621 / DSM 15236 / T118.

Entry informationi

Entry nameiMDH1_ALBFT
AccessioniPrimary (citable) accession number: Q21XH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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