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Q21XE6 (UPPP_RHOFD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Rfer_1829
OrganismRhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) [Complete proteome] [HAMAP]
Taxonomic identifier338969 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAlbidiferax

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000250255

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane218 – 23821Helical; Potential
Transmembrane249 – 26921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q21XE6 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: D09251055B6219CB

FASTA27729,913
        10         20         30         40         50         60 
MDIVLLIKAA IMGLVEGLTE FLPISSTGHL ILAGTLLGFD NEVGKVFDIA IQTGAIFAVI 

        70         80         90        100        110        120 
LVYWQKIRDT LVALPTEKQA QRFSLNVLIA FVPAVVLGLL FGKAIKAHLF TPVVVASTFI 

       130        140        150        160        170        180 
IGGFIILWAE RRQEKNPAAV RIHDVESMTP MDALKVGLAQ CLAMIPGTSR SGATIIGGML 

       190        200        210        220        230        240 
LGLSRKAATD FSFYLAIPTL IGAGVYSLFK ERALLSMADL PTFAVGLVVS FFSAWLCIRW 

       250        260        270 
LLRYIASHSF VGFAYYRIVF GVVVLATAWS GAVTWAA 

« Hide

References

[1]"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15236 / ATCC BAA-621 / T118.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000267 Genomic DNA. Translation: ABD69557.1.
RefSeqYP_523088.1. NC_007908.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338969.Rfer_1829.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD69557; ABD69557; Rfer_1829.
GeneID3961070.
KEGGrfr:Rfer_1829.
PATRIC23236281. VBIRhoFer131161_2151.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycAFER338969:GHU9-1848-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_RHOFD
AccessionPrimary (citable) accession number: Q21XE6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: April 18, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families