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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi377 – 384ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Rfer_2090
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi
  • UP000008332 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei63 – 83HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 163HelicalUniRule annotationAdd BLAST20
Transmembranei167 – 186HelicalUniRule annotationAdd BLAST20
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716481 – 581Lipid A export ATP-binding/permease protein MsbAAdd BLAST581

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi338969.Rfer_2090.

Structurei

3D structure databases

ProteinModelPortaliQ21WN9.
SMRiQ21WN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 311ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini343 – 579ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q21WN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPISLSNR ALYARLLSYV RPYWKAVFLA VIGMVGTAAT EPVFPAIMKY
60 70 80 90 100
LLDNGFQAKD ARMVWLIPMG IVTLFLVRSV IVYCTGYLMT WISSRLVTDL
110 120 130 140 150
RRTMFAKLLA LPTHHYDEHS AGQMISRLVY DVSNVTDAAT SALITLVRES
160 170 180 190 200
LTAIALIGYL LYLDWKLTLI TLAIGPVIAF TVKSFSKRMR AASQKSLQAM
210 220 230 240 250
RFISHTIEET ISAQQVVKIF GGQERQQKQF FEATEQFRRA QMREAIPASA
260 270 280 290 300
MTPITHIAAS VAVAIIAFLA LSQSTGQAGA SAGSFISFIT AMLMLISPVK
310 320 330 340 350
QLATVNPTIQ RGLAASESIF ELLDAAQEDD RGKRQLLRSK GEICFDNVSL
360 370 380 390 400
RYLGAERFAL NDISFRITAG QTVALVGASG GGKSTISALI PRFYPVTSGR
410 420 430 440 450
VLVDGIDIND ITLASLRQNI ALVSQNVILF NDTVGANIAY GSLQTCSRDD
460 470 480 490 500
VIRAARAANA WDFIEQLPNG LDTPIGENGA KLSGGQRQRL AIARALLKDA
510 520 530 540 550
PILILDEATS ALDTESERQV QAALAVLMKN RTTLVIAHRL STIEHADCIL
560 570 580
VLDQGRIVET GTHAELLRAG SYYANLSRLQ G
Length:581
Mass (Da):63,392
Last modified:April 18, 2006 - v1
Checksum:i1F93CD07BAEA2CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA. Translation: ABD69814.1.
RefSeqiWP_011464382.1. NC_007908.1.

Genome annotation databases

EnsemblBacteriaiABD69814; ABD69814; Rfer_2090.
KEGGirfr:Rfer_2090.

Similar proteinsi

Entry informationi

Entry nameiMSBA_RHOFT
AccessioniPrimary (citable) accession number: Q21WN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 18, 2006
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families