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Protein

Thymidylate kinase

Gene

tmk

Organism
Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:Rfer_2255
OrganismiRhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Albidiferax ferrireducens)
Taxonomic identifieri338969 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax
Proteomesi
  • UP000008332 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000232631 – 215Thymidylate kinaseAdd BLAST215

Interactioni

Protein-protein interaction databases

STRINGi338969.Rfer_2255

Structurei

3D structure databases

SMRiQ21W76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiTEAYQGG
OrthoDBiPOG091H02B9

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q21W76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEGIFISF EGIDGAGKST HIDALAQAFR AQGRAVTLTR EPGGTPLAEK
60 70 80 90 100
LRVLVLNDAM DAMTEALLVF AARRDHLQQL IEPALARGDV VLCDRFTDAT
110 120 130 140 150
FAYQGAGRGF DLKILSFLER TVQSIQGLEP DFIRNPDLTV WFDLAAAIAA
160 170 180 190 200
QRLAGARSPD KFEAQPVEFF RRVSDGYLNR MTACPSRFAR IEANQTREAV
210
WQDVLHAVQA RGWLT
Length:215
Mass (Da):23,783
Last modified:April 18, 2006 - v1
Checksum:iE9A5F372840B610F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000267 Genomic DNA Translation: ABD69977.1
RefSeqiWP_011464545.1, NC_007908.1

Genome annotation databases

EnsemblBacteriaiABD69977; ABD69977; Rfer_2255
KEGGirfr:Rfer_2255

Similar proteinsi

Entry informationi

Entry nameiKTHY_RHOFT
AccessioniPrimary (citable) accession number: Q21W76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 18, 2006
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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