ID   AROD_RHOFD              Reviewed;         264 AA.
AC   Q21VV5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=Rfer_2381;
OS   Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Rhodoferax.
OX   NCBI_TaxID=338969;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T.,
RA   Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of chromosome of Rhodoferax ferrireducens DSM
RT   15236.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; CP000267; ABD70098.1; -; Genomic_DNA.
DR   RefSeq; YP_523629.1; -.
DR   GeneID; 3962832; -.
DR   GenomeReviews; CP000267_GR; Rfer_2381.
DR   KEGG; rfr:Rfer_2381; -.
DR   NMPDR; fig|338969.3.peg.2314; -.
DR   HOGENOM; Q21VV5; -.
DR   OMA; Q21VV5; IAKLAVM.
DR   BioCyc; RFER338969:RFER_2381-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   TIGRFAMs; TIGR01093; aroD; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    264       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_0000325529.
FT   ACT_SITE    148    148       Proton acceptor (By similarity).
FT   ACT_SITE    175    175       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   264 AA;  27996 MW;  8EFDE3961667AE8D CRC64;
     MQSSKPIESH GQPIAGGKLP LICVPLVGHT LDEVMAELAI VLPKKPDVLE WRVDFFESIG
     DVAAVIAAAK AIKSKAGDIP LLFTRRSVME GGEKIALNED QVIALYGAVC ESKAIDLIDY
     EMANETANIA QVRAAAKSND IKLVLSFHNF SSTPGLEALA SKFLMADQLG ADIAKVAVMP
     RDPNDVLILL AATQQASQKL RIPLISMSMG PYGSLTRLFG WAFGSALTFA VGARSSAPGQ
     VPIEDLNTVL GILRKAMGDG QTTP
//