Reviewed, UniProtKB/Swiss-Prot Q21VV5 (AROD_RHOFD)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	Rfer_2381

Organism

Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) [Complete proteome] [HAMAP]

Taxonomic identifier

338969 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Rhodoferax

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_0000325529
Sites
	Active site	148	1	Proton acceptor By similarity
	Active site	175	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q21VV5-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 8EFDE3961667AE8D	FASTA	264	27,996
	10 20 30 40 50 60 MQSSKPIESH GQPIAGGKLP LICVPLVGHT LDEVMAELAI VLPKKPDVLE WRVDFFESIG 70 80 90 100 110 120 DVAAVIAAAK AIKSKAGDIP LLFTRRSVME GGEKIALNED QVIALYGAVC ESKAIDLIDY 130 140 150 160 170 180 EMANETANIA QVRAAAKSND IKLVLSFHNF SSTPGLEALA SKFLMADQLG ADIAKVAVMP 190 200 210 220 230 240 RDPNDVLILL AATQQASQKL RIPLISMSMG PYGSLTRLFG WAFGSALTFA VGARSSAPGQ 250 260 VPIEDLNTVL GILRKAMGDG QTTP

References

[1]

"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. , Kyrpides N., Ivanova N., Richardson P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000267 Genomic DNA. Translation: ABD70098.1.
RefSeq	YP_523629.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3962832.
GenomeReviews	Gene locus Rfer_2381 in contig CP000267_GR.
KEGG	rfr:Rfer_2381.
NMPDR	fig|338969.3.peg.2314.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q21VV5.
OMA	Q21VV5. IAKLAVM.
Enzyme and pathway databases
BioCyc	RFER338969:RFER_2381-MON.
Family and domain databases
HAMAP	MF_00214. [Tree]
InterPro	IPR018508. 3-dehydroquinate_DH_AS. IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
ProDom	PD005337. DHquinase_I. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01093. aroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_RHOFD

Accession

Primary (citable) accession number: Q21VV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)