Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q21U05 (GUAC_RHOFD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP reductase
EC=1.7.1.7
Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase
Short name=Guanosine monophosphate reductase
Gene names
Name:guaC
Ordered Locus Names:Rfer_3037
OrganismRhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) [Complete proteome] [HAMAP]
Taxonomic identifier338969 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Albidiferax

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511

Catalytic activity

Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionGMP reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325GMP reductase HAMAP MF_01511
PRO_0000294283

Regions

Nucleotide binding202 – 22524NADP Potential

Sites

Active site1731Thioimidate intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q21U05 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 0DBB4DB4564FB50D

FASTA32535,813
        10         20         30         40         50         60 
MEIFDYDNIL LLPRKCRVES RSECDASVEL GRQRFRIPVV PANMKTVVDE SICVWLAQNS 

        70         80         90        100        110        120 
YFYVMHRFDL DNVQFVKNMK ARGLYASISL GVKKPDYDTV DQLLALGLVP DYITIDIAHG 

       130        140        150        160        170        180 
HADSVKNMIG YLKEKMPTVF IIAGNVATPE AVIDLENWGA DATKVGIGPG KVCITKLKTG 

       190        200        210        220        230        240 
FGTGGWQLSA VKWCARVATK PIIADGGIHE HGDIAKSIRF GATMVMIGSM LAGHEESPGK 

       250        260        270        280        290        300 
SVEVDGKLYK EYYGSASDFN KGEYKHVEGK RILEPVKGKL ADTLIEMEQD VQSSISYSGG 

       310        320 
KRLMDIRKVN YVTLGGDNAG EHLLM

« Hide

References

[1]"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15236 / ATCC BAA-621 / T118.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000267 Genomic DNA. Translation: ABD70748.1.
RefSeqYP_524279.1. NC_007908.1.

3D structure databases

ProteinModelPortalQ21U05.
SMRQ21U05. Positions 3-314.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ21U05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3961012.
GenomeReviewsGene locus Rfer_3037 in contig CP000267_GR.
KEGGrfr:Rfer_3037.
NMPDRfig|338969.3.peg.3457.
PATRIC23238823. VBIRhoFer131161_3407.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0516.
HOGENOMHBG298985.
OMAPDYITID.
PhylomeDBQ21U05.
ProtClustDBPRK05458.

Enzyme and pathway databases

BioCycRFER338969:RFER_3037-MONOMER.

Family and domain databases

HAMAPMF_01511. GMP_reduct_type2.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR005994. GMP_reduct2.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK00364.
PANTHERPTHR11911:SF30. PTHR11911:SF30. 1 hit.
PfamPF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFPIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMsTIGR01306. GMP_reduct_2. 1 hit.
PROSITEPS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAC_RHOFD
AccessionPrimary (citable) accession number: Q21U05
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: April 18, 2006
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents