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Q21SX1 (DDL_ALBFT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Rfer_3423
OrganismAlbidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) (Rhodoferax ferrireducens) [Complete proteome] [HAMAP]
Taxonomic identifier338969 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeRhodoferax

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341165

Regions

Domain125 – 325201ATP-grasp
Nucleotide binding151 – 20656ATP By similarity

Sites

Metal binding2781Magnesium or manganese 1 By similarity
Metal binding2921Magnesium or manganese 1 By similarity
Metal binding2921Magnesium or manganese 2 By similarity
Metal binding2941Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q21SX1 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 58D8C494A9A7B3C2

FASTA34636,268
        10         20         30         40         50         60 
MSQIGINDGA SQQPAGTTLG GVAARLGKVA VLMGGASAER EVSLMSGQGV LQALISQGVD 

        70         80         90        100        110        120 
AHAFDPAERD LAELKVEGFS HCFIALHGRF GEDGTVQGAL ELLGIPYTGS GVMASSIAID 

       130        140        150        160        170        180 
KVMTKRIWRS EGLPTPEWRQ VDSAAATSEA FAALGSPMIV KPDREGSTIG LTKVTQIEQC 

       190        200        210        220        230        240 
GAAYALAARH DAMVLCEQFV KGDEVTIPLL GSGAGAHALP VIRIVAPDGN YDYQNKYFTD 

       250        260        270        280        290        300 
TTQYLVPANL PAGEEAHIQQ LALKAYQVLG CRGWARVDVM IDARTRAPFL LEINTSPGMT 

       310        320        330        340 
PHSLVPMAAK AAGVSYPALC LEVLRHATLD YAAAGGDAQQ PSTEPA 

« Hide

References

[1]"Complete sequence of chromosome of Rhodoferax ferrireducens DSM 15236."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H., Schmutz J., Larimer F., Land M. expand/collapse author list , Kyrpides N., Ivanova N., Richardson P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-621 / DSM 15236 / T118.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000267 Genomic DNA. Translation: ABD71132.1.
RefSeqYP_524663.1. NC_007908.1.

3D structure databases

ProteinModelPortalQ21SX1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING338969.Rfer_3423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD71132; ABD71132; Rfer_3423.
GeneID3963349.
KEGGrfr:Rfer_3423.
PATRIC23239635. VBIRhoFer131161_3812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAWATKLVA.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycAFER338969:GHU9-3465-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_ALBFT
AccessionPrimary (citable) accession number: Q21SX1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 18, 2006
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways